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| Parameters | Description |
|---|---|
| Pi | Pi, nucleotide diversity, is a concept in molecular genetics which is used to measure the degree of polymorphism within a population. |
| Theta | Theta, watterson estimator is a method for describing the genetic diversity in a population. It was developed by Margaret Wu and G. A. Watterson in the 1970s. It is estimated by counting the number of polymorphic sites. It is a measure of the "population mutation rate" (the product of the effective population size and the neutral mutation rate) from the observed nucleotide diversity of a population. |
| Tajima's D |
Tajima's D is a population genetic test statistic created by and named after the Japanese researcher Fumio Tajima. Tajima's D is computed as the difference between two measures of genetic diversity: the mean number of pairwise differences and the number of segregating sites, each scaled so that they are expected to be the same in a neutrally evolving population of constant size. A negative Tajima's D signifies an excess of low frequency polymorphisms relative to expectation, indicating population size expansion (e.g., after a bottleneck or a selective sweep) and/or purifying selection. A positive Tajima's D signifies low levels of both low and high frequency polymorphisms, indicating a decrease in population size and/or balancing selection. |
| CLR | CLR, composite likelihood ratio, is a estimator to detect directional selection from DNA sequence data. The higher the value, the higher possibility of positive selection at the test region. |
| Positive selection | Positive selection, or directional selection is a mode of natural selection in which an extreme phenotype is favored over other phenotypes, causing the allele frequency to shift over time in the direction of that phenotype. Under directional selection, the advantageous allele increases as a consequence of differences in survival and reproduction among different phenotypes. The increases are independent of the dominance of the allele, and even if the allele is recessive, it will eventually become fixed. |
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