Strain
Cow_AB354579
(Region: Japan; Strain: Bovine coronavirus genomic RNA, complete genome, strain: Kakegawa.; Date: 1980)
Gene
small envelope protein
Description
Annotated in NCBI,
small envelope protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTTATGGCTGATGCTTATTTTGCAGACACTGTGTGGTATGTGGGGCAAATAATTTTTATAGTTGCCATTTGTTTATTGGTTATAATAGTTGTACTGGCATTTTTGGCAACTTTTAAATTGTGTATTCAACTTTGCGGTATGTGTAATACCTTAGTACTGTCCCCTTCTATTTATGTGTTTAATAGAGGTAGGCAGTTTTATGAGTTTTACAACGATGTAAAACCACCAGTTCTTGATGTGGATGACGTTTAG
Protein
MFMADAYFADTVWYVGQIIFIVAICLLVIIVVLAFLATFKLCIQLCGMCNTLVLSPSIYVFNRGRQFYEFYNDVKPPVLDVDDV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Keywords
Apoptosis
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Feature
chain Envelope small membrane protein
Uniprot
Pubmed
EMBL
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
KEGG
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
84
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
33.02037
Exp number, first 60 AAs:
32.36062
Total prob of N-in:
0.35770
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 84
