Strain
Murine_AB551247
(Region: Australia:Melbourne; Strain: Murine hepatitis virus RNA, complete genome, strain: MHV-MI.; Date: 1994)
Gene
envelope protein
Description
Annotated in NCBI,
envelope protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTTAATGTACTCTCTACAGACACAGTATGGTATGTGGGGCAGATTATTTTTATAGTCGCAGTGTGTTTAATGGTCACTATAGTTGTGGTCGCTTTCCTTGCGTCTATTAAACTTTGTATTCAACTTTGCGGTTTGTGTAATACTTTGTTGCTGTCCCCTTCTATTTATGTGTATAATAGGAGTAAGCAGCTATATAAGTATTATAATGAAGAAGTGAGACCGCCCCCGTTAGAGGTGGATGATATAATAATCCAAACATTATGA
Protein
MFNVLSTDTVWYVGQIIFIVAVCLMVTIVVVAFLASIKLCIQLCGLCNTLLLSPSIYVYNRSKQLYKYYNEEVRPPPLEVDDIIIQTL
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Keywords
Apoptosis
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Feature
chain Envelope small membrane protein
Uniprot
Pubmed
EMBL
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
PDB
5X29
E-value=0.025 Score=31.2 Identity=28.12%
Cov(Q)=72.73% Cov(P)=79.01%
3D Structure
Ontologies
KEGG
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
88
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
36.2986
Exp number, first 60 AAs:
36.1854
Total prob of N-in:
0.40020
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 88
