Strain
Human_SARS_AY485278
(Region: ; Strain: SARS coronavirus Sino3-11, complete genome.; Date: 2003)
Description
Annotated in NCBI,
envelope protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTACTCATTCTTTTCGGAAGAAACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTCACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTTTAGTAAAACCAACGGTTTACGTCTACTCGCGTGTTAAAAATCTGAACTCTTCTGAAGGAGTTCCTGATCTTCTGGTCTAA
Protein
MYSFFSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
PDB
5X29
E-value=3e-14 Score=61.2 Identity=91.94%
Cov(Q)=81.58% Cov(P)=76.54%
Ontologies
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
24.3564
Exp number, first 60 AAs:
24.34041
Total prob of N-in:
0.51010
POSSIBLE N-term signal
sequence