Strain

Human_HKU1_AY597011 (Region: China: Hong Kong; Strain: Human coronavirus HKU1 genotype A, complete genome.; Date: 2003)

Gene

membrane glycoprotein

Description

Annotated in NCBI, membrane glycoprotein

Location

AY597011(+):27633-28304

GenBank Accession

AAT98584.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAATAAATCTTTTCTTCCTCAATTTACTTCTGATCAAGCTGTTACATTCTTAAAAGAATGGAATTTCTCTTTGGGTGTAATACTACTTTTTATTACTATCATATTGCAGTTCGGTTATACGAGCCGTAGTATGTTTGTTTATCTTATCAAGATGATTATTCTTTGGCTTATGTGGCCATTGACTATCACCTTGACTATATTTAATTGTTTTTATGCTTTGAATAATGCTTTTCTTGCATTTTCTATAGTGTTTACTATTATTTCTATTGTTATATGGATTCTTTATTTTGTTAATAGTATTCGGCTTTTTATTAGAACTGGCAGTTGGTGGAGTTTTAATCCAGAGACCAATAATCTTATGTGTATTGATATGAAAGGCAAGATGTTTGTTAGGCCAGTTATTGAGGACTATCACACATTAACTGCTACTGTTATTCGTGGTCATCTTTATATACAGGGTGTCAAACTTGGCACTGGTTATACTCTTTCAGATTTGCCCGTATATGTTACTGTAGCTAAGGTGCAAGTACTTTGTACCTATAAACGTGCCTTTTTAGATAAGTTAGATGTTAATAGTGGTTTTGCTGTTTTTGTTAAGTCTAAAGTTGGTAACTATCGTTTACCGTCTAGTAAACCTAGTGGTATGGATACTGCCTTGTTAAGAGCTTAA

Protein

MNKSFLPQFTSDQAVTFLKEWNFSLGVILLFITIILQFGYTSRSMFVYLIKMIILWLMWPLTITLTIFNCFYALNNAFLAFSIVFTIISIVIWILYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGKMFVRPVIEDYHTLTATVIRGHLYIQGVKLGTGYTLSDLPVYVTVAKVQVLCTYKRAFLDKLDVNSGFAVFVKSKVGNYRLPSSKPSGMDTALLRA

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

A0A513RAU2

EMBL

MH687884 MH687885 QCI55925.1 QCI55926.1

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

A0A513RAU2

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

223

Number of predicted TMHs:

Exp number of AAs in TMHs:

64.41361

Exp number, first 60 AAs:

31.73317

Total prob of N-in:

0.63867

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 39

inside

40 - 45

TMhelix

46 - 68

outside

69 - 77

TMhelix

78 - 100

inside

101 - 223