Strain
Feline_DQ010921
(Region: ; Strain: Feline coronavirus strain FIPV 79-1146, complete genome.; Date: )
Gene
polyprotein 1a
Description
Annotated in NCBI,
polyprotein 1a
Location
GenBank Accession
Full name
Replicase polyprotein 1a
Alternative Name
ORF1a polyprotein
Sequence
CDS
ATGAGTTCCAAACAATTTAAGATCCTCGTTAATGAGGACTACCAAGTCAACGTTCCTAGCCTTCCTTTCCGTGACGCACTGCAGGAAATTAAGTACTGCTACCGTAACGGTTTTGATGGCTATGTCTTCGTGCCTGAATACCGTCGTGACCTAGTTGATTGCAATCGTAAGGATCACTACGTCATTGGTGTTTTGGGTAACGGAATAAGTGATCTTAAACCTGTTCTCCTTACCGAACCTTCCGTCATGTTGCAGGGTTTCATTGTTAGAGCCAACTGCAATGGCGTTCTTGAGGACTTTGACCTTAAATTCGCCCGTACTGGAAACGGCGCCATATATGTGGACCAATACATGTGTGGTGCTGATGGAAAGCCAGTTATTGAAGGTGAGTTTAAGGATTATTTCGGTGATGAGGACGTTATCATCTATGAAGGAGAGGAGTACCATTGTGCCTGGCTAACAGTGCGCGATGAAAAACCTTTATGTCAACAAACTCTCCTTACAATTAGGGAAATCCAATACAACCTGGGTATCCCACATAAGTTGCCAAATTGTGCTATCAGAGAGGTAGCACCACCAGTCAAGAAGAATTCTAAGGTTGTTCTTTCTGAAGAGTATAGAAAACTCTATGACATCTTCGGCTCGCCATTTATGGGCAATGGAGACAGTCTTAACACGTGTTTTGACAGCCTTCACTTCATTGCTGCCACCCTTAAGTGTCCTTGTGGCGCTGAAAGTAGTGGTGTTGGTGATTGGACTGGCTTTAAGACTGCTTGTTGTGGTCTCCATGGCAAAGTTAAAGGTGTCACATTAGGTGCTGTTAAGCCAGGTGATGCCATTGTCACTAGCATGAGTGCTGGCAAGGGTGTAAAATTCTTTGCTAATAGTGTACTCCAATATGCTGGTGATGTGGAAAATGTCTCTGTTTGGAAAGTGATTAAAACTTTCACTGTTAATGAGACTGTCTGCACCACTGATTTTGAAGGCGAATTGAACGACTTCATTAGACCAGAGAGTACTTCGCCTGTTTCATGCTCCATTAAGAGAGCTTTCATCACAGGTGAAGTTGATGATGCAGTCCATGATTGTATTATCGCAGGAAAGTTGGATCTTAGTACTAATCTTTTTGGTAGTGCTAACCTGCTTTTTAAGAAAATGCCCTGTTTTGTGCAAAAGTGTGGTGCGATTTTTGCTGATGCTTGGAAAGTTGTTGAAGAACTGCTTTGTTCTCTTAAACTTACATACAAGCAAATTTATGATGTAGTAGCATCACTCTGCACTTCTGCTTTTACTATTATGGACTACAAACCTGTATTTGTAGTTTCATCTAATAGTGTTAAGGACCTCGTTGATAAGTGTGTTAAAATTCTTGTGAAAGCCTTCGATGTCTTCACACAGACAATTACCATTGCAGGTGTAGAGGCTAAGTGCTTTGTGCTTGGTTCTAAATACTTGCTTTTTAACAATGCACTTGTTAAGCTTGTCAGTGTTAAAATACTTGGTAAGAGACAAAAAGGTCTTGATAGTGCATTCTTTGCCACTAACTTAATTGGTGCTACTGTTAATGTGACACCACAACGGACTGAGTCAGCCTACATTAGCCTGAATAAAGTAGATGACGTTGTTACGCCTGGTGGAGGTCATATTGTCATTATTGGTGATATGGCTTTTTACAAGAGTGAAGAATACTATTTTATGATGGCAAGCCCTGATTCAGTCCTTGTTAATAATGTTTTTAAAGCCGCGCGAGTGCCATCTTATAACATTGTTTATGATGTGAATGATGACACCAAGAGTAAGATGGTGGTTAAAATAGGAACATCATTCGACTTTGATGGTGACCTCGATGCTGCTATTGCTAAGGTTAATGACTTACTTATTGAGTTTAGACAAGAAAAGTTGTGTTTCAGAGCGCTTAAGGATGGTGAAAACATCCTAGTTGAGGCATATCTTAAGAAGTACAAGATGCCAGTTTGTCTTAAAAACCATGTTGGTTTATGGGACATCATACGACAAGATTCCGGTAAGAAGGGTTTTCTTGACACTTTCAATCATCTTAATGAATTGGAGGACGTCAAGGATATAAAAATTCAGACCATTAAAAACATTATTTGTCCTGACCTCCTACTGGAATTGGATTTTGGTGCCATCTGGTACAGATGCATGCCAGCATGCTCTGACAAGTCCATTTTAGGTAATGTTAAAATCATGCTAGGCAATGGTGTTAAAGTAGTTTGTGATGGTTGTCACAGTTTTGCTAATCGTTTAACGATTAATTACAATAAACTCTGTGACACAGCTCGCAAAGACATTGAAATTGGTGGCATACCGTTTTCCACCTTTAAAACACCATCTAGCAGTTTTATTGATATGAAAGATGCTATCTATTCCGTAGTTGAATATGGTGAAGCACTCTCTTTTACGACTGCAAGTGTGCCTGTAACTAATAGTGGCATCATTACAACTGATGACTGGTCAGATCCCATTTTGTTAGAACCTGCAGATTATGTTGAACCTAAAGACAATGGCGATGTAATTGTCATTGCTGGATACACCTTTTACAAGGATGAAGATGATCATTTTTATCCATATGGTTCTGGCATGGTTGTGCAGAAAATGTACAACAAGATGGGTGGTGGTGACAAGTCAGTTTCGTTTTCAGACAATGTTAATGTTAGAGAGATAGAACCTGTTACACGTGTCAGGCTAGAATTTGAGTTTGACAATGAGGTGGTAACACAGGTGCTTGAAAAAGTCATTGGTACCAAATATAAATTTATAGGTACCACTTGGGAAGAGTTTGAAGATTCTATCTCCGAGAAACTTGACAAAATTTTTGACACGCTTGCTGAGCAGGGTGTAGAACTTGAAGGCTATTTCATTTACGACACATGTGGTGGATTTGACATTAATAACCCAGATGGTGTTATGATTTCACAGTACGATCTTAACACAGCTGCTGATGACAAAAGCGATTCTGATGCAAGTGTGGAAGACATCTCTTTGATTTCTGACAACGAAGATGTTGAACAAATTGAAGAAGATAAACCTTCCTTGACCCCATTCAAGACAACAAATCTTAATGGTAAAATCATACTTAAACAACAAGATAATAATTGTTGGATAAACGCTTGCTGTTATCAATTGCAAGCCTTTGATTTCTTCAACCATGATTTGTGGGATGGTTTTAAGAAAGATGATGTTATGCCTTTTGTAGACTTTTGTTATGCAGCTCTAACTTTGAAGCAGGGTGATTCAGGGGATGCAGAATACCTTTTGGAGACGATGCTCAATGATTATAGTACAGCTAAAGTCACACTTAGTGCTAAGTGCGGCTGTGGTGTTAAAGAGATAGTTTTAGAACGAACTGTGTTTAAGCTCACACCTCTTAGGAATGAGTTTAAATATGGTGTCTGTGGTGACTGTAAGCAAATTAACATGTGTAAGTTTGCTAGCGTGGAAGGTTCTGGTGTTTTTGTTCATGATAGAATTGAAAAACAGACACCTGTGTCACAATTTATTGTGACACCTACTATGCATGCAGTTTACACAGGTACAACACAGAGTGGTCATTATATGATTGAAGATTGCATTCATGATTACTGTGTGGATGGTATGGGAATTAAACCTCGTAAACATAAGTTTTACACATCCACTTTGTTTCTTAATGCAAATGTAATGACAGCTAAATCTAAAACTATGGTTGAACCACCTGTGCCCGTAGAGGATAAGTGTGTAGAAGACTGTCAAAGTCCTAAAGATCTTATACTACCCTTTTATAAAGCGGGAAAAGTCTCATTTTACCAAGGAGATTTAGATGTTTTGATTAACTTTCTTGAGCCTGACGTCCTTGTTAACGCTGCTAATGGTGATCTTAGACACGTGGGTGGCGTTGCTAGAGCTATTGATGTATTCACAGGTGGTAAGTTAACAAAACGCTCTAAGGAGTACCTTAAATCCAGCAAAGCAATAGCTCCTGGTAATGCTGTGCTTTTTGAAAACGTACTTGAGCATCTTAGTGTGTTGAATGCTGTAGGACCACGTAATGGTGACAGTAGAGTTGAAGGTAAACTCTGTAATGTCTACAAAGCAATCGCTAAGTGTGATGGTAAGATACTAACACCACTTATTAGTGTTGGTATCTTCAAAGTCAAACTGGAAGTTTCGTTGCAGTGTCTACTTAAAACTGTCACAGATAGAGATTTAAATGTCTTTGTTTACACTGACCAAGAGAGAGTTACCATAGAAAATTTTTTCAATGGTACTATTCCTATCAAGGTAACGGAAGATACTGTGAATCAAAAGCGTGTGTCTGTAGCACTTGATAAAACTTATGGTGAGCAACTCAAAGGAACTGTTGTTATTAAAGACAAAGATGTTACTAACCAGTTGCCAAGTGTGTCAGATGTCGGTGAAAAAGTCGTTAAGGCATTGGATGTTGATTGGAATGCTTACTATGGCTTTCCAAATGCAGCAGCTTTTAGCGCCAGTTCCCATGATGCTTATGAATTTGATGTTGTAACACATAACAACTTCATTGTTCATAAGCAAACTGATAATAATTGTTGGGTTAATGCAATTTGTTTAGCATTACAGAGACTTAAACCAACATGGAAGTTTCCTGGTGTTAAAAGTTTGTGGGATGCATTTCTCACGCGTAAAACTGCTGGATTTGTACATATGCTATATCACATTTCGGGCTTAACGAAAGGACAACCTGGCGATGCCGAGTTGACTTTACATAAGCTTGTTGATTTGATGTCAAGTGATAGTGCAGTTACTGTCACACACACAACTGCATGTGATAAGTGCGCTAAAGTTGAAACTTTCACAGGTCCTGTGGTAGCGGCACCTCTTTTGGTTTGTGGCACTGATGAAATTTGTGTCCATGGTGTACATGTCAATGTTAAAGTGACAAGCATTAGAGGTACTGTGGCTATCACTTCTTTAATAGGTCCTGTAGTGGGTGACGTTATTGATGCAACTGGTTACATTTGCTACACTGGTTTGAATTCGCGTGGCCATTATACCTACTACGATAATCGTAATGGTTTAATGGTTGATGCCGATAAGGCCTACCATTTCGAGAAAAACCTTTTACAGGTCACAACAGCCATTGTTAGTAATTTTGTTGCTAACACGCCTAAGAAGGAGATTATGCCTAAGACTCAAGCTAAAGAATCAAAAGCTAAAGAATCAAATACGGCTCGTGTTTTTAGTGAGGTTGAAGAAAATCCTAAAAATATAGTTCGTAAAGAAAAATTGTTAGCTATTGAGAGTGGTGTAGATTATACAATCACAACACTCGGTAAATATGCTGACGTATTCTTTATGGCTGGTGATAAAATTCTTAGGTTTCTCCTTGAAGTCTTTAAATATTTATTGGTTGTTTTTATGTGTCTTAGAAAATCTAAGATGCCTAAAGTTAAAGTAAAACCACCACACGTATTTAGAAACTTGGGTGCTAAAGTTAGAACATTGAATTATGTAAGACAATTGAACAAACCAGCCCTGTGGCGTTACATAAAACTAGTACTACTTTTAATAGCATTATATCATTTTTTCTATTTGTTTGTCAGCATACCAGTAGTGCACAAATTGGCATGTAGTGGTAGTGTTCAAGCATATAGTAATTCTAGTTTTGTAAAGTCGGAAGTTTGTGGTAATTCTATTTTGTGCAAGGCGTGTCTGGCATCTTATGATGAATTGGCAGATTTTGATCATCTCCAGGTGTCATGGGATTACAAGTCAGACCCACTATGGAATAGAGTTATACAATTGTCGTATTTTATATTCTTGGCTGTTTTTGGTAACAATTATGTTAGATGTCTTCTTATGTATTTTGTCTCCCAGTACCTTAACCTGTGGTTATCTTATTTTGGTTATGTTAAGTATAGCTGGTTTTTGCATGTTGTCAACTTTGAATCAATTTCTGTTGAATTTGTAATCATAGTTGTGGTTTTTAAGGCAGTTCTCGCACTTAAACACATTTTCCTACCATGCAACAACCCGTCATGTAAGACATGTTCTAAAATTGCTAGGCAGACGCGCATTCCTATACAGGTTGTGGTTAACGGTTCAATGAAGACTGTGTATGTCCATGCTAATGGTACTGGTAAACTCTGCAAAAAGCATAACTTTTATTGTAAGAATTGTGACTCTTATGGGTTTGATCACACATTTATTTGTGATGAGATTGTGCGTGATCTAAGTAACAGCATTAAGCAAACTGTTTATGCTACTGATAGGTCATACCAGGAAGTCACAAAAGTTGAATGTACCGACGGGTTTTATAGGTTCTATGTTGGTGAAGAATTCACGGCATATGACTATGATGTAAAACATAAGAAGTATAGTAGTCAGGAGGTGCTTAAGACAATGTTCCTGCTTGATGACTTCATTGTTTACAACCCATCAGGGTCTTCTCTTGCTAGTGTTAGAAACGTCTGTGTTTACTTCTCACAATTAATTGGTAGGCCTATTAAGATCGTTAATAGTGAGTTGCTTGAGGATTTATCTGTAGACTTTAAGGGAGCACTCTTTAATGCCAAAAAGAATGTTATTAAAAACTCTTTTAATGTGGATGTTTCAGAATGTAAGAATCTTGAAGAGTGTTACAAGTTGTGTAACCTCGACGTGACATTCTCCACTTTTGAAATGGCAATTAATAATGCTCACAGATTTGGTATATTAATTACAGACCGATCTTTTAACAATTTTTGGCCATCGAAGATTAAGCCTGGTTCTTCTGGTGTTTCTGCTATGGATATCGGTAAGTGCATGACTTTTGATGCTAAGATTGTTAATGCAAAGGTTTTAACACAACGTGGTAAAAGTGTTGTATGGCTCAGTCAGGATTTCTCCACTCTTAGTTCTACAGCACAAAAGGTTTTAGTTAAAACGTTTGTGGAGGAGGGTGTAAATTTTTCACTCACATTTAATGCTGTTGGTTCAGATGAAGATCTGCCGTATGAGCGGTTCACTGAATCTGTTTCGGCAAAGAGCGGTTCAGGTTTCTTTGATGTACTTAAACAGCTTAAACAACTCTTCTGGTGTCTTGTTTTGTTCATTACCCTTTATGGTTTATGCTCAGTCTACAGTGTTGCAACTCAGTCTTATATTGATTCTGCTGAGGGTTATGATTACATGGTTATTAAGAACGGTGTTGTTCAATCATTTGATGATTCTATTAACTGTGTACATAATACATACAAAGGCTTTGCAGTGTGGTTTAAAGCTAAACATGGTTTTGTACCTACATTTGACAAGTCCTGCCCTATTGTTTTAGGAACTGTTTTTGATTTAGGTAATATGAGACCAATCCCTGATGTGCCTGCGTATGTAGCACTTGTTGGTAGATCCTTAGTGTTCGCAATCAATGCTGCATTTGGCGTTACTAATGTGTGCTATGATCATACTGGTGCCGCTGTAAGTAAGAATTCTTACTTTGACACTTGTGTCTTCAATTCTGCGTGCACTACTCTAACTGGCATTGGTGGTACAGTCGTTTATTGTGCTAAGCAAGGACTTGTTGAGGGTGCTAAGCTTTACAGTGAATTGCTGCCTGATTATTATTATGAGCATGCTAGTGGTAACATGGTAAAAATACCAGCCATTATTAGGAGTTTTGGTCTACGGTTTGTAAAAACACAGGCTACAACTTATTGCAGAGTGGGAGAGTGTACTGAAAGTCAAGCTGGTTTTTGCTTCGGTGGCGACAACTGGTTTGTCTATGATAAAGAGTTTGGAGATGGTTACATTTGTGGAAGTTCCACATTGGGATTCTTCAAAAATGTGTTCGCACTCTTTAATTCTAATATGTCTGTAGTAGCTACATCTGGTGCAATGTTGGCTAACATTGTTATTGCATGCTTAGCTATTGCAGTCTGTTATGGTGTTCTTAAGTTTAAAAAGATCTTTGGTGATTGCACTCTCTTAGTAGTTATGATTATTGTTACATTGGTTGTTAATAATGTTTCATACTTTGTAACCCAAAACACATTCTTTATGATTGTTTATGCTATCATCTATTATTTCACAACAAGAAAACTTGCATACCCAGGTGTTTTAGATGCGGGGTTCATTATCGCATACTTGAATATGGCCCCATGGTATGTTCTTGTTTTGTATATAATGGTGTTCCTTTATGATTCCCTACCATCACTATTCAAACTTAAAGTAACAACAAACCTCTTTGAAGGTGATAAATTTGTAGGTAGTTTCGAATCAGCAGCTATGGGTACTTTTGTTATAGATATGCGTTCATATGAAACACTTGTTAATTCTACATCTCTAGATAGAATTAAGTCATATGCTAACAGCTTTAACAAGTATAAGTACTATACTGGTTCGATGGGAGAGGCTGATTACCGCATGGCTTGCTACGCTCATTTAGGTAAGGCGTTAATGGATTATTCTGTTTCAAGAAATGATAAGCTTTATACGCCACCAACGGTCAGTGTCAATTCAACACTGCAGTCCGGATTGAGAAAAATGGCACAGCCTAGTGGTGTTGTGGAACCCTGTATTGTAAGGGTGGCTTATGGCAATAATGTTCTTAATGGTTTGTGGCTTGGAGATGAAGTCATCTGCCCTAGACACGTCATTGCTAGTGATACATCGCGAGTGATCAATTATGAGAATGAGTTGTCTAGTGTGCGTTTACATAACTTTTCTATAGCCAAAAATAATGCGTTTTTGGGTGTTGTGTCTGCCAAATATAAGGGTGTAAATCTTGTGCTTAAAGTGAATCAGGTAAACCCTAACACACCAGAACATAAATTTAAATCCGTGAGGCCAGGTGAGAGTTTTAACATTCTTGCTTGTTATGAAGGCTGTCCCGGTAGTGTCTACGGTGTTAACATGAGAAGTCAGGGTACTATCAAAGGTTCATTTATTGCTGGTACCTGTGGGTCAGTAGGTTATGTATTAGAAAATGGAACGCTCTATTTCGTGTACATGCACCACTTGGAATTAGGTAATGGTTCTCATGTTGGTTCAAATCTTGAAGGGGAAATGTATGGCGGTTATGAAGATCAGCCTAGCATGCAATTGGAGGGTACTAATGTCATGTCATCAGATAATGTAGTTGCATTTTTGTATGCTGCTCTTATTAATGGTGAGAGATGGTTTGTTACAAACACATCAATGACGTTAGAATCTTACAATGCATGGGCCAAAACCAATAGTTTTACGGAAATTGTGTCAACTGATGCTTTTAATATGTTGGCTGCAAAAACTGGTTATAGTGTTGAAAAGTTGCTTGAGTGTATTGTTAGACTCAATAAAGGTTTTGGAGGACGTACTATACTGTCTTATGGCTCTCTGTGTGACGAATTCACGCCTACTGAAGTCATAAGGCAAATGTATGGTGTTAATCTTCAGAGTGGTAAAGTGAAATCGATATTTTACCCTATGATGACTGCCATTGCCATTCTTTTTGCATTCTGGTTAGAATTCTTCATGTATACACCCTTCACATGGATTAACCCGACATTTGTTAGTGTTGTTCTAGCTATTACAACACTTGTATCTGTGTTGTTAGTTGCTGGAATTAAACACAAAATGTTGTTCTTTATGTCTTTTGTGATGCCTAGTGTTATTTTAGTTACTGCACATAATGTGGTCTGGGATATGACCTATTATGAAAGTTTACAGGTGCTTGTGGAAAACGTTAATACCACTTTCTTACCAGTCGATATGCAGGGTGTCATGCTTGCACTGTTCTGTGTAGTTGTGTTTGTTATATGCACTATAAGATTTTTTACATGCAAGCAGTCGTGGTTTTCACTGTTTGCAACAACTATTTTTGTGATGTTTAACATTGTCAAGTTACTAGGTATGATAGGTGAGCCATGGACTGATGACCACTTTTTGTTGTGTCTTGTAAACATGCTTACTATGTTGATAAGTCTTACTACAAAGGATTGGTTTGTTGTCTTTGCATCATACAAAGTTGCTTATTACATAGTTGTGTATGTAATGCAGCCAGCTTTTGTTCAAGATTTTGGCTTTGTTAAGTGCGTAAGCATAATTTACATGGCTTGCGGTTATCTATTCTGTTGTTATTACGGTATCCTTTACTGGGTTAACAGGTTTACATGCATGACGTGTGGTGTTTACCAATTTACGGTTTCACCGGCCGAGCTCAAATACATGACTGCTAATAATTTGTCTGCACCTAAGACTGCATATGATGCTATGATTCTTAGTTTTAAGTTGATGGGCATTGGTGGAGGACGTAATATCAAAATATCCACTGTGCAGTCTAAACTTACAGAGATGAAGTGTACAAATGTTGTCTTGCTCGGTCTTTTGTCTAAAATGCATGTTGAATCTAATTCAAAAGAGTGGAATTATTGTGTTGGTTTGCATAATGAAATCAATTTGTGTGACGACCCTGACGCCGTCCTCGAAAAATTACTTGCGCTCATTGCATTCTTTTTGTCCAAGCATAACACATGTGATCTTAGTGATCTTATTGAGTCCTATTTTGAGAACACCACTATTTTACAGAGTGTAGCATCTGCTTATGCTGCTTTGCCTAGCTGGATTGCCTATGAAAAAGCTCGTGCCGATCTAGAAGAGGCTAAGAAGAATGATGTTAGCCCTCAACTTTTGAAACAGCTTACAAAGGCTTGTAATATCGCTAAGAGCGAATTTGAGCGAGAAGCTTCCGTGCAAAAGAAGCTTGACAAAATGGCAGAGCAGGCTGCAGCTAGCATGTACAAAGAGGCACGCGCCGTGGACAGGAAGTCAAAAATAGTTTCAGCTATGCATAGTTTACTCTTTGGTATGCTCAAGAAACTCGACATGTCCAGTGTTAATACCATTATTGAACAGGCTCGTAATGGCGTGTTACCATTGAGCATTATACCAGCTGCCTCAGCTACAAGACTTATTGTTGTAACACCTAATCTTGAAGTGCTTTCCAAGGTTAGGCAAGAAAACAATGTACACTATGCAGGTGCCATTTGGTCAATTGTTGAGGTTAAGGATGCTAATGGCGCTCAAGTCCACTTGAAAGAAGTTACAGCTGCCAATGAATTAAACATAACCTGGCCCTTGAGTATAACTTGTGAGAGAACCACAAAGTTGCAGAATAATGAAATCTTGCCAGGTAAACTTAAAGAGAAAGCTGTTAAAGCATCTGCTACAATTGATGGCGATGCTTATGGTAGCGGTAAAGCGCTTATGGCTTCTGAAGGTGGTAAGAGCTTTATATATGCATTTATAGCATCAGACAGCAACCTTAAGTATGTTAAATGGGAGAGCAACAATGATGTAATACCTATTGAACTTGAGGCTCCATTGCGCTTTTATGTAGATGGTGTTAATGGTCCTGAGGTTAAATATTTGTATTTTGTGAAAAGCTTGAACACTCTTAGACGTGGTGCTGTTCTTGGTTATATCGGTGCAACGGTTCGTCTGCAAGCTGGTAAACCTACTGAACACCCATCTAATAGTGGTTTGCTGACATTGTGTGCTTTTGCACCTGACCCTGCTAAAGCATATGTTGACGCTGTTAAACGAGGTATGCAGCCAGTTACCAACTGTGTAAAAATGCTCTCAAATGGTGCCGGTAATGGTATGGCTATCACAAATGGCGTCGAATCTAACACACAACAGGACTCTTATGGTGGCGCATCTGTATGTATTTATTGTAGATGTCATGTAGAACATCCTGCAATTGATGGATTGTGCCGCTTTAAAGGTAAATTCGTCCAAGTACCAACCGGGACTCGGGATCCTATTAGATTCTGTATTGAAAATGAAGTTTGCGTCGTTTGCGGTTGCTGGCTTACTAATGGTTGTATGTGTGATCGTACTTCTATACAAGGCACCACTATTGATCAGAGTTATTTAAACGAGTGCGGGGTTCTAGTGCAGCTCGACTAG
Protein
MSSKQFKILVNEDYQVNVPSLPFRDALQEIKYCYRNGFDGYVFVPEYRRDLVDCNRKDHYVIGVLGNGISDLKPVLLTEPSVMLQGFIVRANCNGVLEDFDLKFARTGNGAIYVDQYMCGADGKPVIEGEFKDYFGDEDVIIYEGEEYHCAWLTVRDEKPLCQQTLLTIREIQYNLGIPHKLPNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNTCFDSLHFIAATLKCPCGAESSGVGDWTGFKTACCGLHGKVKGVTLGAVKPGDAIVTSMSAGKGVKFFANSVLQYAGDVENVSVWKVIKTFTVNETVCTTDFEGELNDFIRPESTSPVSCSIKRAFITGEVDDAVHDCIIAGKLDLSTNLFGSANLLFKKMPCFVQKCGAIFADAWKVVEELLCSLKLTYKQIYDVVASLCTSAFTIMDYKPVFVVSSNSVKDLVDKCVKILVKAFDVFTQTITIAGVEAKCFVLGSKYLLFNNALVKLVSVKILGKRQKGLDSAFFATNLIGATVNVTPQRTESAYISLNKVDDVVTPGGGHIVIIGDMAFYKSEEYYFMMASPDSVLVNNVFKAARVPSYNIVYDVNDDTKSKMVVKIGTSFDFDGDLDAAIAKVNDLLIEFRQEKLCFRALKDGENILVEAYLKKYKMPVCLKNHVGLWDIIRQDSGKKGFLDTFNHLNELEDVKDIKIQTIKNIICPDLLLELDFGAIWYRCMPACSDKSILGNVKIMLGNGVKVVCDGCHSFANRLTINYNKLCDTARKDIEIGGIPFSTFKTPSSSFIDMKDAIYSVVEYGEALSFTTASVPVTNSGIITTDDWSDPILLEPADYVEPKDNGDVIVIAGYTFYKDEDDHFYPYGSGMVVQKMYNKMGGGDKSVSFSDNVNVREIEPVTRVRLEFEFDNEVVTQVLEKVIGTKYKFIGTTWEEFEDSISEKLDKIFDTLAEQGVELEGYFIYDTCGGFDINNPDGVMISQYDLNTAADDKSDSDASVEDISLISDNEDVEQIEEDKPSLTPFKTTNLNGKIILKQQDNNCWINACCYQLQAFDFFNHDLWDGFKKDDVMPFVDFCYAALTLKQGDSGDAEYLLETMLNDYSTAKVTLSAKCGCGVKEIVLERTVFKLTPLRNEFKYGVCGDCKQINMCKFASVEGSGVFVHDRIEKQTPVSQFIVTPTMHAVYTGTTQSGHYMIEDCIHDYCVDGMGIKPRKHKFYTSTLFLNANVMTAKSKTMVEPPVPVEDKCVEDCQSPKDLILPFYKAGKVSFYQGDLDVLINFLEPDVLVNAANGDLRHVGGVARAIDVFTGGKLTKRSKEYLKSSKAIAPGNAVLFENVLEHLSVLNAVGPRNGDSRVEGKLCNVYKAIAKCDGKILTPLISVGIFKVKLEVSLQCLLKTVTDRDLNVFVYTDQERVTIENFFNGTIPIKVTEDTVNQKRVSVALDKTYGEQLKGTVVIKDKDVTNQLPSVSDVGEKVVKALDVDWNAYYGFPNAAAFSASSHDAYEFDVVTHNNFIVHKQTDNNCWVNAICLALQRLKPTWKFPGVKSLWDAFLTRKTAGFVHMLYHISGLTKGQPGDAELTLHKLVDLMSSDSAVTVTHTTACDKCAKVETFTGPVVAAPLLVCGTDEICVHGVHVNVKVTSIRGTVAITSLIGPVVGDVIDATGYICYTGLNSRGHYTYYDNRNGLMVDADKAYHFEKNLLQVTTAIVSNFVANTPKKEIMPKTQAKESKAKESNTARVFSEVEENPKNIVRKEKLLAIESGVDYTITTLGKYADVFFMAGDKILRFLLEVFKYLLVVFMCLRKSKMPKVKVKPPHVFRNLGAKVRTLNYVRQLNKPALWRYIKLVLLLIALYHFFYLFVSIPVVHKLACSGSVQAYSNSSFVKSEVCGNSILCKACLASYDELADFDHLQVSWDYKSDPLWNRVIQLSYFIFLAVFGNNYVRCLLMYFVSQYLNLWLSYFGYVKYSWFLHVVNFESISVEFVIIVVVFKAVLALKHIFLPCNNPSCKTCSKIARQTRIPIQVVVNGSMKTVYVHANGTGKLCKKHNFYCKNCDSYGFDHTFICDEIVRDLSNSIKQTVYATDRSYQEVTKVECTDGFYRFYVGEEFTAYDYDVKHKKYSSQEVLKTMFLLDDFIVYNPSGSSLASVRNVCVYFSQLIGRPIKIVNSELLEDLSVDFKGALFNAKKNVIKNSFNVDVSECKNLEECYKLCNLDVTFSTFEMAINNAHRFGILITDRSFNNFWPSKIKPGSSGVSAMDIGKCMTFDAKIVNAKVLTQRGKSVVWLSQDFSTLSSTAQKVLVKTFVEEGVNFSLTFNAVGSDEDLPYERFTESVSAKSGSGFFDVLKQLKQLFWCLVLFITLYGLCSVYSVATQSYIDSAEGYDYMVIKNGVVQSFDDSINCVHNTYKGFAVWFKAKHGFVPTFDKSCPIVLGTVFDLGNMRPIPDVPAYVALVGRSLVFAINAAFGVTNVCYDHTGAAVSKNSYFDTCVFNSACTTLTGIGGTVVYCAKQGLVEGAKLYSELLPDYYYEHASGNMVKIPAIIRSFGLRFVKTQATTYCRVGECTESQAGFCFGGDNWFVYDKEFGDGYICGSSTLGFFKNVFALFNSNMSVVATSGAMLANIVIACLAIAVCYGVLKFKKIFGDCTLLVVMIIVTLVVNNVSYFVTQNTFFMIVYAIIYYFTTRKLAYPGVLDAGFIIAYLNMAPWYVLVLYIMVFLYDSLPSLFKLKVTTNLFEGDKFVGSFESAAMGTFVIDMRSYETLVNSTSLDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYSVSRNDKLYTPPTVSVNSTLQSGLRKMAQPSGVVEPCIVRVAYGNNVLNGLWLGDEVICPRHVIASDTSRVINYENELSSVRLHNFSIAKNNAFLGVVSAKYKGVNLVLKVNQVNPNTPEHKFKSVRPGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYVLENGTLYFVYMHHLELGNGSHVGSNLEGEMYGGYEDQPSMQLEGTNVMSSDNVVAFLYAALINGERWFVTNTSMTLESYNAWAKTNSFTEIVSTDAFNMLAAKTGYSVEKLLECIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGVNLQSGKVKSIFYPMMTAIAILFAFWLEFFMYTPFTWINPTFVSVVLAITTLVSVLLVAGIKHKMLFFMSFVMPSVILVTAHNVVWDMTYYESLQVLVENVNTTFLPVDMQGVMLALFCVVVFVICTIRFFTCKQSWFSLFATTIFVMFNIVKLLGMIGEPWTDDHFLLCLVNMLTMLISLTTKDWFVVFASYKVAYYIVVYVMQPAFVQDFGFVKCVSIIYMACGYLFCCYYGILYWVNRFTCMTCGVYQFTVSPAELKYMTANNLSAPKTAYDAMILSFKLMGIGGGRNIKISTVQSKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPDAVLEKLLALIAFFLSKHNTCDLSDLIESYFENTTILQSVASAYAALPSWIAYEKARADLEEAKKNDVSPQLLKQLTKACNIAKSEFEREASVQKKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIEQARNGVLPLSIIPAASATRLIVVTPNLEVLSKVRQENNVHYAGAIWSIVEVKDANGAQVHLKEVTAANELNITWPLSITCERTTKLQNNEILPGKLKEKAVKASATIDGDAYGSGKALMASEGGKSFIYAFIASDSNLKYVKWESNNDVIPIELEAPLRFYVDGVNGPEVKYLYFVKSLNTLRRGAVLGYIGATVRLQAGKPTEHPSNSGLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKMLSNGAGNGMAITNGVESNTQQDSYGGASVCIYCRCHVEHPAIDGLCRFKGKFVQVPTGTRDPIRFCIENEVCVVCGCWLTNGCMCDRTSIQGTTIDQSYLNECGVLVQLD
Summary
Function
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Catalytic Activity
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Produced by conventional translation.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
3D-structure
Activation of host autophagy by virus
Host cytoplasm
Host membrane
Host-virus interaction
Hydrolase
Inhibition of host innate immune response by virus
Inhibition of host IRF3 by virus
Inhibition of host RLR pathway by virus
Membrane
Metal-binding
Modulation of host ubiquitin pathway by viral deubiquitinase
Modulation of host ubiquitin pathway by virus
Protease
Reference proteome
Repeat
Ribosomal frameshifting
RNA-binding
Thiol protease
Transmembrane
Transmembrane helix
Ubl conjugation pathway
Viral immunoevasion
Zinc
Zinc-finger
Feature
chain Replicase polyprotein 1a
Uniprot
Proteomes
Pfam
Interpro
IPR009003
Peptidase_S1_PA
IPR014822 NSP9
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR038634 A-CoV_nsp1_sf
IPR013016 Peptidase_C30/C16
IPR018995 RNA_synth_NSP10_coronavirus
IPR032505 Corona_NSP4_C
IPR032039 A-CoV_nsp1
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR014828 NSP7
IPR036333 NSP10_sf
IPR014829 NSP8
IPR002589 Macro_dom
IPR014827 Viral_protease
IPR036499 NSP9_sf
IPR014822 NSP9
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR038634 A-CoV_nsp1_sf
IPR013016 Peptidase_C30/C16
IPR018995 RNA_synth_NSP10_coronavirus
IPR032505 Corona_NSP4_C
IPR032039 A-CoV_nsp1
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR014828 NSP7
IPR036333 NSP10_sf
IPR014829 NSP8
IPR002589 Macro_dom
IPR014827 Viral_protease
IPR036499 NSP9_sf
SUPFAM
ProteinModelPortal
PDB
5EU8
E-value=0.0 Score= 627 Identity=100.00%
Cov(Q)=7.62% Cov(P)=98.37%
3D Structure
Ontologies
GO
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0008242 F:omega peptidase activity
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0039520 P:induction by virus of host autophagy
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039648 P:modulation by virus of host protein ubiquitination
GO:0019079 P:viral genome replication
GO:0036459 F:thiol-dependent ubiquitinyl hydrolase activity
GO:0039548 P:suppression by virus of host IRF3 activity
GO:0008270 F:zinc ion binding
GO:0019082 P:viral protein processing
GO:0016021 C:integral component of membrane
GO:0033644 C:host cell membrane
GO:0008242 F:omega peptidase activity
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0039520 P:induction by virus of host autophagy
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039648 P:modulation by virus of host protein ubiquitination
GO:0019079 P:viral genome replication
GO:0036459 F:thiol-dependent ubiquitinyl hydrolase activity
GO:0039548 P:suppression by virus of host IRF3 activity
GO:0008270 F:zinc ion binding
GO:0019082 P:viral protein processing
GO:0016021 C:integral component of membrane
GO:0033644 C:host cell membrane
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 4 publications.
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 4 publications.
Topology
Length:
3965
Number of predicted TMHs:
14
Exp number of AAs in TMHs:
421.134980000001
Exp number, first 60 AAs:
0.00047
Total prob of N-in:
0.00042
outside
1 - 1782
TMhelix
1783 - 1801
inside
1802 - 1840
TMhelix
1841 - 1863
outside
1864 - 1923
TMhelix
1924 - 1946
inside
1947 - 1965
TMhelix
1966 - 1988
outside
1989 - 2609
TMhelix
2610 - 2632
inside
2633 - 2644
TMhelix
2645 - 2679
outside
2680 - 2693
TMhelix
2694 - 2716
inside
2717 - 3133
TMhelix
3134 - 3156
outside
3157 - 3160
TMhelix
3161 - 3183
inside
3184 - 3189
TMhelix
3190 - 3209
outside
3210 - 3233
TMhelix
3234 - 3256
inside
3257 - 3260
TMhelix
3261 - 3283
outside
3284 - 3309
TMhelix
3310 - 3328
inside
3329 - 3340
TMhelix
3341 - 3363
outside
3364 - 3965
