Sequence

CDS

ATGACGTTTCCTAGGGCATTGACTGTCATAGATGACAATGGAATGGTCATTAACATCATTTTCTGGTTCCTGTTGATAATTATATTGATATTACTTTCAATAGCATTGCTAAATATAATTAAGCTATGCATGGTGTGTTGCAATTTAGGAAGGACAGTTATTATTGTTCCAGCGCAACATGCTTACGATGCCTATAAGAATTTTATGCGAATTAAAGCATACAACCCCGATGGAGCACTCCTTGCTTGA

Protein

MTFPRALTVIDDNGMVINIIFWFLLIIILILLSIALLNIIKLCMVCCNLGRTVIIVPAQHAYDAYKNFMRIKAYNPDGALLA

Summary

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Similarity

Belongs to the alphacoronaviruses E protein family.

Keywords

Apoptosis Host Golgi apparatus Host membrane Membrane Reference proteome Transmembrane Transmembrane helix

Feature

chain Envelope small membrane protein

Uniprot

P09048

Pubmed

2825819 10805807

EMBL

X06371 AJ271965 X12800

Proteomes

UP000001440

Pfam

PF02723 NS3_envE

Interpro

IPR003873 NS3/E

ProteinModelPortal

P09048

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0046760  P:viral budding from Golgi membrane
GO:0016021  C:integral component of membrane
GO:0044662  P:disruption by virus of host cell membrane

Subcellular Location

From MSLVP

From Uniprot

Host Golgi apparatus membrane The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.

Topology

Length:

Number of predicted TMHs:

Exp number of AAs in TMHs:

23.98981

Exp number, first 60 AAs:

23.90336

Total prob of N-in:

0.04933

POSSIBLE N-term signal

sequence

outside

1 - 14

TMhelix

15 - 37

inside

38 - 82