Strain

Bat_EF065508 (Region: China: Guangdong province; Strain: Bat coronavirus HKU4-4, complete genome.; Date: 2005)

Gene

membrane glycoprotein

Description

Annotated in NCBI, membrane glycoprotein

Location

EF065508(+):28030-28689

GenBank Accession

ABN10872.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCGTCGAACGGTAGTCTTACCAAAGATGAGGTAGTAAATATTATTAAGGACTGGAATTTTTCATGGTCCATAATATTCCTACTTATTACTATCGTACTCCAATATGGTTATCCATCTAGGAGTATGATGGTTTACGTCTTTAAGATGTTCATATTATGGCTTTTATGGCCAGCTTCTATGGCACTGTCCATATTTAGTGCTATTTATCCTATTAGTTTATCATCCCAGATTATATCTGGCATTCTAGCAGCAATCTGTGCTGTTATGTGGCTAGCGTACTTTGTTCAGAGTATAAGGCTATTTATGCGCACTGGTTCCTGGTGGTCTTTTAATCCAGAATCTAATTGTCTGCTCAATGTCCCAATCGGTGGTACAACAGTTGTTAGGCCCTTGGTCGAAGATTCGACTAGTGTTACTGCTGTTGTCAACGATGGTCATCTTAAGATGGCTGGTATGCACTTTGGTCGCTGTGACTACGATAGACTTCCTATGGAAATCACCGTAGCCAAGCCCTCTGTGCTTATAGCACTTAAGATGGTTAAACGCCAATCATATGGTACAAATTCTGGTGTTGCCATATTCCATAGGTATAAAGCTGGTAATTATAGAAGACCTACTATTATACAAGATGAAGAACTTGCATTGCTTAGGGCATAG

Protein

MSSNGSLTKDEVVNIIKDWNFSWSIIFLLITIVLQYGYPSRSMMVYVFKMFILWLLWPASMALSIFSAIYPISLSSQIISGILAAICAVMWLAYFVQSIRLFMRTGSWWSFNPESNCLLNVPIGGTTVVRPLVEDSTSVTAVVNDGHLKMAGMHFGRCDYDRLPMEITVAKPSVLIALKMVKRQSYGTNSGVAIFHRYKAGNYRRPTIIQDEELALLRA

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

A4ZU13

Pubmed

17434558

EMBL

EF424618 ABP38270.1

Proteomes

UP000173415

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

A4ZU13

Ontologies

GO:0019031  C:viral envelope
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0039660  F:structural constituent of virion
GO:0016021  C:integral component of membrane
GO:0019058  P:viral life cycle
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

219

Number of predicted TMHs:

Exp number of AAs in TMHs:

62.4894

Exp number, first 60 AAs:

30.63357

Total prob of N-in:

0.20297

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 38

inside

39 - 50

TMhelix

51 - 73

outside

74 - 77

TMhelix

78 - 95

inside

96 - 219