Strain

Bat_EF065513 (Region: China_Guangdong_province; Strain: Rousettus bat coronavirus HKU9; Date: )

Gene

membrane glycoprotein

Description

Annotated in NCBI, membrane glycoprotein

Location

EF065513(+):25689-26357

GenBank Accession

ABN10914.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCTAATAATTGTACTAACACTGTGCCTCGTCCTGAGGTTATAGCTGCTTTAAAAGACTGGAACTTTGCAGTTTCAGTCATATTGTTGTTTATAACCGTGCTATTGCAGTGGGGTTATCCTTCTCGTTGTAAACCCATATGGGTTATCAAGATGTTTATACTTTGGTTACTATGGCCGTTGTCCATAGCGGCCGCTGTTTTTGCAGCTATACACCCAATCAATTCAGTTGCTTTTGGTTTTGCTATAGCTTTTGCCTGTATTTCAGGCATTATGTGGTTGAGCTATTTTATTAGCTCATTCCGCCTACTCTGTAGGACAGGCTCAGCCTGGTCTTTTATGCCAGAAACTGATATGCTTATTAACATACCCCTTTTAGGGCGTACTGTAACTAGGCCTATCATTTCAGACTCACCTGCTGTTCAATTTTTGATTATCAGAGGTGAGCTTAGGTTTGATGGTTTCACCCTAGGTCGTTGTGACCCGGGTGATATGCCTGACATTGTTACTATTGCTAGACCTAATGCATTGCACTGGTATAAGCGAGCACTTACTCGCAATATGTATACTCGTTCAGCTATCCTTGTTTATATTAAATACAAGGTTGGCAACCACCGTGTGCAGAATACCACAGAGGATGGTGATAGGTTAGCAATGTTTGTAGCTTAA

Protein

MSNNCTNTVPRPEVIAALKDWNFAVSVILLFITVLLQWGYPSRCKPIWVIKMFILWLLWPLSIAAAVFAAIHPINSVAFGFAIAFACISGIMWLSYFISSFRLLCRTGSAWSFMPETDMLINIPLLGRTVTRPIISDSPAVQFLIIRGELRFDGFTLGRCDPGDMPDIVTIARPNALHWYKRALTRNMYTRSAILVYIKYKVGNHRVQNTTEDGDRLAMFVA

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

Q66VB9

EMBL

AY702026 AAU07933.1

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

Q66VB9

Ontologies

GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane

Subcellular Location

From MSLVP

Topology

Length:

222

Number of predicted TMHs:

Exp number of AAs in TMHs:

63.40975

Exp number, first 60 AAs:

30.22364

Total prob of N-in:

0.72735

POSSIBLE N-term signal

sequence

inside

1 - 20

TMhelix

21 - 38

outside

39 - 47

TMhelix

48 - 70

inside

71 - 76

TMhelix

77 - 99

outside

100 - 222