Strain
Bat_EF065516
(Region: China: Guangdong province; Strain: Bat coronavirus HKU9-4, complete genome.; Date: 2005)
Gene
nucleocapsid phosphoprotein
Description
Annotated in NCBI,
nucleocapsid phosphoprotein
Location
GenBank Accession
Full name
Nucleoprotein
Sequence
CDS
ATGTCTGGACGGAATAAGCCCCGCCCCGGCAGTCAATCACCTAAGGTGACGTTCAAACAAGAATCAGACGGTTCTGACTCCGAATCCGAACGCCGTAATGGTAACCGTTCTGGTGCCCGTCCTAAGAATAATAATAACAGAGGTGGTAATTCCAAGCCTGAGAAACCTAAGGCAGCCCCTCCGCAGAATGTTTCTTGGTTTGCTCCCCTTGTCCAAACGGGAAAGCAAGATCTGCGTTTCCCACGTGGAGAAGGAGTGCCCATAAGTCAAGGTGTAGACCCTGTCTATCTCCATGGCTACTGGGTGCGTACACAGCGCAATTTCCAAAAAGGTGGCAAAACTGTGCAGGCTAACCCCCGCTGGTACTTCTATTATACTGGTACCGGCCGTCATGCGGACCTCCGCTGGGGACAGAAGAACCCAGATTTGATTTGGGTTGGTGAAGATGGTGCCAATATAAACCGCATTGGTGATATGGGCACGCGTAATCCAAATAATGACTCTGCTATCCCAGTACAATTTGGCAGTGGCATTCCCAAGGGCTTTTATGCTGAAGGTCGCAACTCACGTGGCAATAGCCGCAACAGTTCGCGTAATTCCAGCAGGGCTTCCACGCGTGGAAACTCCAGAGCTAATTCAAGAGGTGCTTCTCCTGGCAGAAACACACCTAGTGGTGGTTCAAACTCTGAACCCTGGATGGCCTATCTGGTGCAGAAGTTGGAAGCACTGGAAACTAAGGTCAATGGCAATAAGTCAGAAACCAAAGCACCAGTGCAAGTCACCAAGAATGCTGCAGCTGAGAATGCCAAGAAGCTCAGGCATAAGAGAACACCTCATAAGGGCAGTGGTGTAACGGCCAACTTCGGCAGACGAGGACCTGGTGAATTAGAGGGTAATTTTGGGGATCTAGAAATGCTGAAACTAGGTGCAGACGACCCTAGGTTTCCTGCCGTTGCGCAAATGGCCCCTAATGTAGCTGCATTCATGTTCATGTCACACTTTAGCACTCGTGACGAAGAAGACGCACTTTGGCTCAACTATAGAGGAGCTATCAAGTTGCCTAAGTCAGATCCCAATTTTGAGCAATGGACTAAGTTGCTCGAGGAGAACTTGAATGCATACAAAACATTCCCTCCACCAGCGCCCAAGAAAGATAAGAAGAAGAAGGAAGAAGCCAGTCAGGAGATTGCCATCTTTGAGGATGCTTCCACCGGTACTGACCAACAGATCGTGAAAGTGTGGGTCAAAGATGAAGGTGCTCAGACTGACGAAGAATGGTTAGGCGGAGATGACACCGTCTATGAAGAAGAAGATGACAGACCTAAGACTCAGAGGAGACACAAGAAGAGGAATTCAACAGCGTCACGTGTGACGATTGCTGATCCTATGAATGCAACATCTGAAAGGTCCTAA
Protein
MSGRNKPRPGSQSPKVTFKQESDGSDSESERRNGNRSGARPKNNNNRGGNSKPEKPKAAPPQNVSWFAPLVQTGKQDLRFPRGEGVPISQGVDPVYLHGYWVRTQRNFQKGGKTVQANPRWYFYYTGTGRHADLRWGQKNPDLIWVGEDGANINRIGDMGTRNPNNDSAIPVQFGSGIPKGFYAEGRNSRGNSRNSSRNSSRASTRGNSRANSRGASPGRNTPSGGSNSEPWMAYLVQKLEALETKVNGNKSETKAPVQVTKNAAAENAKKLRHKRTPHKGSGVTANFGRRGPGELEGNFGDLEMLKLGADDPRFPAVAQMAPNVAAFMFMSHFSTRDEEDALWLNYRGAIKLPKSDPNFEQWTKLLEENLNAYKTFPPPAPKKDKKKKEEASQEIAIFEDASTGTDQQIVKVWVKDEGAQTDEEWLGGDDTVYEEEDDRPKTQRRHKKRNSTASRVTIADPMNATSERS
Summary
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit
Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Uniprot
Pubmed
EMBL
Pfam
PF00937
Corona_nucleoca
ProteinModelPortal
PDB
4UD1
E-value=5e-31 Score= 117 Identity=46.21%
Cov(Q)=30.85% Cov(P)=88.41%
3D Structure
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus > host nucleolus. Host cytoplasm. Secreted.
From Uniprot
Host Golgi apparatus
Host endoplasmic reticulum-Golgi intermediate compartment
Virion
Host endoplasmic reticulum-Golgi intermediate compartment
Virion
Topology
Length:
470
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01095
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00430
outside
1 - 470
