Strain
Human_TGEV_EU074218
(Region: China; Strain: Transmissible gastroenteritis virus strain attenuated H, complete genome.; Date: presumed 2007)
Gene
membrane protein
Description
Annotated in NCBI,
membrane protein
Location
GenBank Accession
Full name
Membrane protein
Alternative Name
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Sequence
CDS
ATGAAGATTTTGTTGATATTAGCGTGTGTGATTGCATGCGCATGTGGAGAACGCTATTGTGCTATGAAAGACGATACAGGTTTGTCATGTCGCAATAGCACAGCGTCTGATTGTGAGTCATGCTTCAACGGAGGCTATCTTATTTGGCATCTTGCAAACTGGAACTTCAGCTGGTCTATAATATTGATTATTTTTATTACTGTGCTACAATATGGAAGACCTCAATTCAGCTGGTTCGTGTATGGCATTAAAATGCTTATAATGTGGCTATTATGGCCCATTGTTTTGGCTCTTACGATTTTTAATGCATACTCGGAATACCAAGTGTCCAGATATGTAATGTTCGGCTTTAGTATTGCAGGTGCAATTGTTACATTTGTACTCTGGATTATGTATTTTGTAAGATCCATTCAGTTGTACAGAAGGACTAAGTCTTGGTGGTCCTTCAACCCTGAAACTAACGCAATTCTTTGCGTTAGTGCATTAGGAAGAAGCTATGTGCTTCCTCTCGAAGGTGTGCCAACTGGTGTCACTCTAACTTTGCTTTCAGGGAATTTGTACGCTGAAGGGTTCAAAATTGCAGGTGGTATGAACATCGACAATTTGCCAAAATACGTAATGGTTGCATTACCCAGCAGGACTATTGTCTACACACTTGTTGGCAAGAAGTTGAAAGCAAGTAGTGCGACTGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGAGGCAAGAACTGATAATTTGAGTGAGCAAGAAAAATTATTACATATGGTATAA
Protein
MKILLILACVIACACGERYCAMKDDTGLSCRNSTASDCESCFNGGYLIWHLANWNFSWSIILIIFITVLQYGRPQFSWFVYGIKMLIMWLLWPIVLALTIFNAYSEYQVSRYVMFGFSIAGAIVTFVLWIMYFVRSIQLYRRTKSWWSFNPETNAILCVSALGRSYVLPLEGVPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKKLKASSATGWAYYVKSKAGDYSTEARTDNLSEQEKLLHMV
Summary
Function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Similarity
Belongs to the alphacoronaviruses M protein family.
Keywords
Glycoprotein
Host Golgi apparatus
Host membrane
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Feature
chain Membrane protein
Uniprot
Proteomes
PRIDE
Pfam
PF01635
Corona_M
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Virion membrane
Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Topology
Length:
262
Number of predicted TMHs:
3
Exp number of AAs in TMHs:
74.66091
Exp number, first 60 AAs:
18.07403
Total prob of N-in:
0.45123
POSSIBLE N-term signal
sequence
inside
1 - 45
TMhelix
46 - 68
outside
69 - 77
TMhelix
78 - 100
inside
101 - 111
TMhelix
112 - 134
outside
135 - 262
