Strain
Bat_GQ153543
(Region: China: Hong Kong; Strain: Bat SARS coronavirus HKU3-8, complete genome.; Date: 15/02/2006)
Gene
small membrane protein
Description
Annotated in NCBI,
small membrane protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTAATTCTTTTCCTTGCTTTCGTGGTATTCTTGCTAGTCACAATAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAATGTGAGTTTAGTAAAACCAACAGTTTACGTTTACTCACGTGTTAAAAATCTGAACTCTTCTGAGGGAGTTCCTGATCTTCTGGTCTAA
Protein
MYSFVSEETGTLIVNSVILFLAFVVFLLVTIAILTALRLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
PDB
5X29
E-value=5e-22 Score=80.9 Identity=88.71%
Cov(Q)=81.58% Cov(P)=76.54%
3D Structure
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
76
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
24.28793
Exp number, first 60 AAs:
24.27447
Total prob of N-in:
0.61093
POSSIBLE N-term signal
sequence
inside
1 - 11
TMhelix
12 - 34
outside
35 - 76
