Strain

Avian_JF699749 (Region: China; Strain: Duck coronavirus isolate DK/CH/HN/ZZ2004 M protein (M) mRNA; Date: 4-May)

Gene

M protein

Description

Annotated in NCBI, M protein

Location

JF699749(+):1-681

GenBank Accession

AEO88932.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCGGACGGCACGGGAAATTGCACTCTTAGTACTCAGCAAGCGGCTGAGCTATTCAAGGAATATAATCTATTTATAACCGCATTCTTGTTGTTCCTAACCATACTACTTCAGTATGGATATGCAACTAGGAGTCGGTTTATTTACATACTGAAAATGATAGTGTTATGGTGTTTCTGGCCCCTTAACATTGCAATAGGTGTAATTTCATGTATATACCCACCAGATACAGGAGGCCTTGTTGCTGCGATAATTCTCACTGTGTTTGCGTGTCTATCTTTTCTAGGTTATTGGATTCAGAGCATTAGGCTCTTTAAACGGTGCAGGTCTTGGTGGTCGTTCAACCCAGAGAGCAATGCCGTAGGTTCAATACTCCTAACTAATGGTCAACAATGTAATTTTGCTATAGAGAGTGTGCCAATGGTGCTTTCTCCAATTATTAAGAATGGTGCTCTTTATTGTGAAGGCCAGTGGCTTGCTAAGTGTGAACCAGACCACTTGCCTAAAGATATATTTGTTTGCACACCTGATAGGCGAAACATCTATCGTATGGTGCAGAAATACACTGGTGACCAAAGCGGAAATAAGAAAAGGTTTGCTACATTTGTCTATGCCAAGCAGTCGGTAGACAGCGGAGAGCTAGAAAGTGTATCAACTAGTGTAGGTAGCCTTTACACATAA

Protein

MSDGTGNCTLSTQQAAELFKEYNLFITAFLLFLTILLQYGYATRSRFIYILKMIVLWCFWPLNIAIGVISCIYPPDTGGLVAAIILTVFACLSFLGYWIQSIRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLSPIIKNGALYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDSGELESVSTSVGSLYT

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A1P8VEW6

EMBL

KX302871 APZ73755.1

Pfam

PF01635 Corona_M

Interpro

IPR042550 GAMMA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

A0A1P8VEW6

Ontologies

GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Topology

Length:

226

Number of predicted TMHs:

Exp number of AAs in TMHs:

63.01844

Exp number, first 60 AAs:

30.20893

Total prob of N-in:

0.04624

POSSIBLE N-term signal

sequence

outside

1 - 23

TMhelix

24 - 41

inside

42 - 47

TMhelix

48 - 70

outside

71 - 79

TMhelix

80 - 99

inside

100 - 226