Strain
Murine_JF792616
(Region: ; Strain: Rat coronavirus isolate 681, complete genome.; Date: )
Gene
nucleocapsid
Description
Annotated in NCBI,
nucleocapsid
Location
GenBank Accession
Full name
Nucleoprotein
Alternative Name
Nucleocapsid protein
Sequence
CDS
ATGTCTTTTGTTCCCGGACAAGAAAACGCCGGTAGCAGAAGCTCCTCTGGAAACCGCGCTGGTAATGGAATCCTCAAGAAGACCACTTGGGCTGACCAAACCGAGCGCGGACAAAATAATGGAAATAGAGGCAGAAGGAATCAGCCCAAGCAGACTGCAACTACTCAGCCCAATACCGGGAGTGTGGTTCCCCATTACTCTTGGTTTTCGGGCATTACCCAATTCCAGAAGGGAAAAGAGTTCCAGTTTGCAGGTGGACAAGGAGTGCCTATTGCCAATGGAATCCCACCTTCTGAGCAAAAGGGATATTGGTATAGACACAACCGTCGTTCTTTTAAAACACCTGATGGGCAGCAGAAGCAACTACTCCCCAGATGGTATTTTTACTATCTTGGGACGGGCCCCCATGCTGGAGCCAGTTTCGGAGACAGCATTGAGGGAGTCTTCTGGGTTGCAAATAGTCAGGCGGATACCAACACCTCTGCTGACATTGTTGAAAGGGACCCAAGTAGCCATGAGGCTATTCCTACTAGGTTTGCGCCCGGTACGGTATTGCCTCAGGGTTTCTATGTTGAAGGCTCGGGAAGGTCTGCACCTGCTAGTCGATCTGGTTCGCGGTCACAATCCCGTGGGCCAAATAATCGCGCTAGAAGCAGTTCCAACCAGCGCCAAGCTGCCTCTACTGTAAAACCTGATATGGCCGAAGAAATTGCTGCTCTTGTTTTGGCTAAGCTAGGCAAAGATGCCGGACAGCCTAAGCAAGTAACTAAGCAAAGTGCCAAAGAAGTCAGGCAGAAAATTTTAAATAAGCCTCGCCAAAAGAGGACTCCAAACAAGCAGTGCCCAGTGCAGCAGTGTTTTGGAAAGAGAGGCCCCAATCAGAATTTTGGAGGCCCTGAAATGTTAAAACTTGGAACTAGTGATCCACAGTTCCCCATTCTTGCAGAGTTGGCCCCAACACCTGGTGCCTTCTTCTTTGGATCTAAATTAGAATTGGTCAAAAAGAATTCTGGTGGCGTTGATGAACCCACCAAAGATGTGTATGAGCTGCAATATTCAGGTGCAGTCAGATTTGATAGTACTCTACCTGGTTTTGAGACTATCATGAAAGTGTTGAATGAGAATTTGAACGCCTACCAGAATCAAGCTGGTGGTGCAGATGTAGTGAGCCCAAAGCCCCAAAGAAAGAGAGGGACGAAACAAACGGCTCAGAAAGAAGAATTAGATAGTATAAGCGTTGCAAAGCCCAAAAGTGCCGTGCAGCGAAATGTAAGCAGAGAATTWACCCCAGAGGATAGAAGCCTGTTGGCGCAGATCCTAGATGATGGCGTTGTGCCTGATGGGTTAGATGACTCTAATGTGTAA
Protein
MSFVPGQENAGSRSSSGNRAGNGILKKTTWADQTERGQNNGNRGRRNQPKQTATTQPNTGSVVPHYSWFSGITQFQKGKEFQFAGGQGVPIANGIPPSEQKGYWYRHNRRSFKTPDGQQKQLLPRWYFYYLGTGPHAGASFGDSIEGVFWVANSQADTNTSADIVERDPSSHEAIPTRFAPGTVLPQGFYVEGSGRSAPASRSGSRSQSRGPNNRARSSSNQRQAASTVKPDMAEEIAALVLAKLGKDAGQPKQVTKQSAKEVRQKILNKPRQKRTPNKQCPVQQCFGKRGPNQNFGGPEMLKLGTSDPQFPILAELAPTPGAFFFGSKLELVKKNSGGVDEPTKDVYELQYSGAVRFDSTLPGFETIMKVLNENLNAYQNQAGGADVVSPKPQRKRGTKQTAQKEELDSISVAKPKSAVQRNVSREXTPEDRSLLAQILDDGVVPDGLDDSNV
Summary
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit
Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Similarity
Belongs to the betacoronavirus nucleocapsid protein family.
Uniprot
Pubmed
EMBL
Pfam
PF00937
Corona_nucleoca
ProteinModelPortal
PDB
3HD4
E-value=9e-92 Score= 274 Identity=96.24%
Cov(Q)=29.30% Cov(P)=95.68%
3D Structure
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus > host nucleolus. Host cytoplasm. Secreted.
From Uniprot
Host Golgi apparatus
Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. With evidence from 1 publications.
Host endoplasmic reticulum-Golgi intermediate compartment Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. With evidence from 1 publications.
Virion Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. With evidence from 1 publications.
Host endoplasmic reticulum-Golgi intermediate compartment Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. With evidence from 1 publications.
Virion Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. With evidence from 1 publications.
Topology
Length:
454
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01169
Exp number, first 60 AAs:
0.0001
Total prob of N-in:
0.00176
outside
1 - 454
