CoVDB Coronavirus Database (v3)   
Strain
Canine_JQ404409 (Region: USA;  Strain: Canine coronavirus strain 1-71, complete genome.;  Date: presumed 2012)
Gene
1ab
Description
Annotated in NCBI,  1ab
GenBank Accession
Full name
Replicase polyprotein 1ab      
Alternative Name
ORF1ab polyprotein
 

Sequence

CDS
ATGAGTTCCAAACAATTCAAGATCCTCGTCAACGAGGACTACCAAGTCAACGTGCCTAGTCTTCCTATTCGTGACGTGTTACAGGAAATTAAGTACTGTTATCGTAATGGATTTGAGGGCTATGTCTTCGTGCCAGAATACTGTCGTGACCTAGTTGATTGCGATCGTAAGGATCACTACGTCATTGGTGTTCTTGGTAACGGAATAAGTGATCTCAAACCTGTTCTTCTTACCGAACCCTCCGTCATGCTGCAAGGTTTTATTGTTAAAGCTATCTGCAATGGCGCTCTTGAGGACTTTGACCTTAAAATTGCTCGTACTGGAAGAGGTGCTATATATGTAGACCAATACATGTGTGGTGCTGATGGAAAACCAGTCATTGAAGGCGATTTTAAGGACTACTTCGGTGATGAGGACATTATTGAATTTGAAGGAGAAGAGTACCATTGCGCTTGGACAACAGTGCGCGATGAAAAACTGCTTAATCAGCAAACTCTCTTTACTATTCAGGAAATACAATATAATCTGGACATTCCTCACAAACTGCCAAATTGTGCTACTAGACATGTAGCACCACCAGTCAAAAAGAACTCTAAAATAGTTCTGTCTGAAGATTACAAGAAGCTTTATGAAATCTTTGGATCACCCTTTATGGGAAATGGTGACTGTCTGAGCAAATGCTTTGACACTCTTCATTTCATTGCTGCAACTCTTAGATGTCCATGTGGCGCAGAGAGTAGTGGTGTTGGTGATTGGACTGGTTTTAAGACTGCTTGTTGTGGTCTTGTTGGCAAAGTTTTGGGTGTCACGCTGGGTGATATTAAGCCTGGTGATGCTGTTGTCACTAGTATGAGCGCTGGTAAAGGAGTTAAATTCTTTGCCAATTGTGTTCTTCAGCATGCTGGTGATGTTGAAAATGTCTCTGTTTGGAAAGTGATTAAAACTTTTACTGTTGACGAGACTGTTTGCACCCCTGACTTTGAAGGCGAATTGAACGACTTCATTAAACCTGAGAGTAAATCACCAACTGCATGCAGCATTAAAAGAGCATTCATTACTGGTGAAATTGATGATGCTGTACATGATTGTATCATTACAGGAAAATTGGATCTTAGCACTAATCTTTTTGGTAATGTTGGTCTACTATTCAAGAAAACTCCCTGGTTTGTACAAAAGTGTGGTGCACTTTTTGTTGATGCTTGGAAAGTAGTAGAGGAACTTCTTGGTTCACTCAAACTCACATACAAGCAAATTTACGAAGTTGTAGCATCACTTTGCACTTCTGCTTTTACGATTGTAAACTACAAACCAACGTTTGTAGTTTTAGACAATCGCGTTAAAGATCTTGTAGACAAGTGTGTGAATATTCTTGTAAAGGCTTTTGATGTTTTTACGCAGACTATCACAATTGCTGGTATTGAAGCCAAATGCTTTGTGCTTGGTGCTAAATACCTGTTGTTCAATAATGCACTTGTCAAACTTGTCAGTGTTAAAATACTTGGCAAGAAGCAAAAGGGTCTCGAAAGTGCATTCTTTGCTACTAGCTTGGTTGGTGCAACTGTTAATGTGACACCGAAAAGAACTGAGACTGCCACTATTAGCTTGAACAAAGTTGATGATGTGGTGGCACCAGGAGAGGGTTATATTGTCATTGTTGGTGATATGGCTTTCTACAAGAGTGGTGAATACTACTTCATGATGGCTAGTCCTGATTCTGTTCTTATTAACAATGTTTTTAAAGCAGCTAGAGTCCCATCTTATGACATCGTGTATGATGTTGATGATGACACCAAGGGCAAGATGACTGCAAAACTTGGTTCATCATTTGAATATGATGGTGATATTGATGCTGCTGTTACTAAAGTCAATGAGTTACTCATTGAATTTAAACAACAAAGTCTTTGTTTTAGAGCACTTAAAGATGACAAAAGCATTTTTGTTGAAGCTTATCTTAAAAAGTACAAAATGCCTGCATGCCTTGCAAAACATATTGGTTTGTGGAACATCATAAAGAAAGATTCATGTAAGAAGGGTTTTCTTAGTCTTTTCAATCACTTGAACGAATTGGAAGACGTCAAAGAAACCAATGTTCAGGCTATTAAGAATATTCTTTGCCCTGATCTTCTTCTTGATCTGGATTATGGTGCCATTTGGTACAAGTGCATGCCGAGTTGCTCTGATTTATCTGTGTTGGGGAGTGTCCAACTTTTGATTGGCAACGGTGTGAAAGTAGTTTGTGATGGCTGCAAAGTTTTTGCTAACCAACTTTCAAATGGTTACAATAAGCTCTGTAATGCTGCTCGCACTGATATTGAAATCGGTGGTATACCATTTTCTACTTTCAAAACACCTACAAATACTTTTATTGAAATGACAGATGCTATCTACTCAGTTATTGAACAAGGTAAAGCATTGTCCTTTGGAAATGCTGATGTGCCAGTTTTAGACAATGGTACCATTTCTACTGATGATTGGTCTGAACCCATTTTGCTTGAACCTGCTGAATATGTGAAACCCAAGAACAATGGTAATGTCATTGTTATTGCAGGTTACACATTTTATAAAGATGAAGATGAACACTTCTATCCTTATGGTTCTGGTAAAATTGTGCAGAGAATGTATAATAAAATGGGTGGTGGTGATAAAACTGTCTCATTTTCAGAAGAAGTAGATGTTCAAGAAATTGCACCTGTTACACGTGTTAATCTTGAATTTGAATTTGACAATGAAATTGTAACTGGTGTGCTTGAGCAGGCTATTGGTACTAGATATAAATTTACTGGTACAACTTGGGAAGAATTTGAAGATTCTATTTCTGAAGAACTTGATGCAATTTTTGATACTCTAGCAAACCAAGGTGTCGAACTTGAAGGTTACTTCATTTATGATACTTGTGGTGGCTTTGATTTCAAAAATCCAGATGGTATTATGATCTCTCAGTATGATATCAATAATATTGCTGATGAAAAATCAGAAACAGGTGCATCAAGTGAGGAAGAAGAAGTTGAGTCTGTTGAAGAAGACGCTGAGAATGAAATTGTAGAAGCATCTGAAGCTATTGAAGAGACTTCTTCTCAAGAAGAGGTAGAAACAGTAGAAGTTGAAGATATTACTTCTGCAGAAGATGTTGAAATTGTGGAAGTGTCTGCTAAGGATGACCCATGGGCTGCTGCTGTTGATGTACAAGAAGCTGAACATGTTAAGCCTTCTTTACCACCTTTCAAGACAACAAATCTTAATGGTAAAATCATCCTTAAACAACAGGATAACAATTGTTGGATAAATGCTTGTTGCTATCAGCTGCAGGCTTTTGACTTTTTCAACAATGAAGCTTGGGAAAAATTTAAGAAAGGTGATGTTATGGATTTTGTCAATCTCTGTTATGCAGCCACAACACTTGAAAGGGGTCATTCTGGTGATGCAGAGTATCTTCTTGAACTTATGCTCAATGACTATAGTACGGCAAAAATAGTACTTGTTGCCAAGTGTGGCTGTGGCGAAAAAGAAATTGTATTGGAAAGAACTGTGTTTAAACTCACTCCATTAAAGGATGAGTTTAATTATGGTGTTTGTGGTGAATGTATGCAAATTAACAGGTGCAAAGTTGCAAGTGTTGAAGGATCTGGTTTGTTTGTACATGATTGTATTGACAAACAGACTCCCACGTCACAATTTATTGTTAAGCCAATTATGCATGCAGTGTACACTGGAACAACTCAAAATGGTCATTACATGGTCGATGACATTGAACATGATTATTGTGTTGATGGTATGGGTATTAAGCCACGTAAGAAACGACTTTACACATCCACACTATTCATCAATGCTAATGTAATGACTAGAGTTGAAAAACCAAAACAACAACCTAAAGTTGAAAAAGTAGAACAGCAACCAGAAATAGAGGAAAAGAAACCTTCAATTGAAAAAGAGGAAGTTCAAAGTCCTAAAAATGATGATCTTATACTTCCATTTTACAAAGCTGGTAAACTTTCCTTTTATCAGGGTGATTTGGATGTTTTGATCAATTTCTTGGAACCTGATGTCATTGTTAATGCTGCCAATGGTGATCTTAAACACATGGGTGGTGTCGCAAGAGCCATCGATGTTTTCACTAGTGGCAAATTAACAGAACGTGTGATGGATTATCTTAAAAAGAACAAATCTATTGCTCCTGGTAATGCTGTTTTCTTTGAAAATGTCATTGAGAATCTTAGTGTTTTGAATGCTGTAGGACCACGTAATGGTGACAGCCGGATTGAAGGCAAACTTAATAATGTCTATAAGGCCATTGCAAAGTGTGAAGGAAAAATACTAACACCACTTATCAGTGTTGGTATTTTCAGTGTTAAACTTGAAATGTCATTGCAGTGCTTACTTAAGACTGTAAATGATAGAGAATTGAATGTCTTCGTGTACACTGATCAGGAGAGACAAGCCATTGAGAACTTCTTCTCTGGTTCTATCCCTGTCAAAGTTACTGAAGATAATGTCAACCATGAACGTGTGTCCGTTTCTTTTGACAAAACATACGGTGAACAACTTAAAGGTACCGTGGTCATTAAAGACAAAGATGTTACAAACCAGTTGCCTAGTGCTTTTGATGTTGGTCAGAAAGTTGTTAAGGCTATTGACGTAGATTGGCAAGCTCATTATGGTTTCCATGATGCTGCTGCCTTTAGTGCTAGTAGCCATGATGCTTACAAGTTTGAAGTCGTTACACATAGCAACTTCATTGTACATAAGCAGACTGATAACAACTGCTGGATTAATGCAATTTGTCTTGCATTACAGAGACTTAAACCTCAATGGAAATTTCCTGGTGTTAGAGGTCTTTGGAATGAATTTCTTGAGCGTAAAACACAAGGTTTTGTACACATGCTGTATCACATTTCAGGAGTAAAGAAAGGTGAGCCAGGTGATGCTGAATTGACTCTGCATAAACTTGGTGATTTGATGGATAATGATTGTGAAATCATTGTCACACATACTACAGCATGTGACAAATGCTCCAAAGTTGAAAAGTTTACTGGACCAGTGGTAGCAGCGCCGCTTGCAATTCATGGCACTGATGAAACATGTGTTCATGGTGTTAGTGTTAATGTTAAAGTTACTCAGATTAAGGGCACTGTTGCTATCACATCTTTGATTGGTCCTATTATTGGAGAAGTACTTGAAGCAACTGGTTACATCTGTTATAGAGGTTCAAGCAAGAATGGTCATTACACCTATTACGACAATCGTAATGGGTTAATGATTGATGCAGAAAAGGCTTACCACTTTAATAAAGACCTATTACAAGTCACGACAGCCATTGCAAGTAATTTTGTTGTCAAGAAACCACAAGTAGAAGAAAAACCTAAGACTCGTGTTTTTAACAGAGTAGATGAGCCTCCAAAGACTATAGTACAAGAACAAAAGTTGTTGGCTATTGAAAGTGGTGCTGATTACGCTCTCACAGAGTTTGGAAGATATGCTGACATGTTCTTTATGGCTGGAGACAAAATTCTTAGGTTTCTGCTTGAAGTCTTTAAATATCTGTTGGTTTTGTTTATGTGTCTTAGAAGTACTAAGATGCCTAAAGTTAAAGTAAAGCCACCTCATGCATTTAAAGACTTAGGTGCTAAAGTTAGAACACTTAATTACATGAGGCAATTGAACAAACCTGCTGTTTGGCGTTATGCAAAACTAGTTTTATTGCTAATAGCAATATATAATTTCTTTTATTTGTTTGTCAGTATACCAGTAGTTCATAAATTAACATGTAGTGGTGCTGTACAGGCATATAAAAATTCTAGTTTTGTGAAGTCAGAAGTTTGTGGTAACTCTATTCTTTGTAAAGCTTGTTTGGCTTCTTATGATGAGCTGGCTGACTTCCAACATCTTCAAGTTGCTTGGGATTTCAAGTCAGATCCACTCTGGAATAAACTGGTACAATTGTCTTATTTTGTATTTTTGGCTGTCTTTGGTAACAATTATGTTAGATGCTTTCTTATGTACTTTGTGTCCCAGTACCTCAACCTGTGGCTTTCTCACTTTGGTTACGTAGAGCACAGCTGGTTTTTGCATGTTGTCAGCTTTGAATCTATTTCAGCTGAGTTTGTGATTATAGTTATTTTGGTTAAGGCAGTTCTCGCTCTTAAACATATTGTCTTCTCATGCTCAAACCCATCTTGTAAAACTTGCTCTAAAACTGCAAGGCAGACACGTATTCCGATACAGGTTGTTGTTAATGGCTCTATGAAGACAGTTTATGTTCATGCCAACGGTACTGGTAAACTCTGCAAGAAACATAACTTTTATTGTAAGAATTGTGATTCTTATGGTTTTGAGAATACATTCATCTGTGACGAAATTGTTCGTGATCTCAGTAATAGTGTTAAACAGACTGTTTATGCTACTGATAGATCTCATCAAGAAGTCACAAAAGTTGAATGTTCAGATGGATTTTACAGGTTCTATGTTGGTGATGAATTCACTTCATATGATTATGATGTAAAACATAAGAAGTACAGTAGTCAAGAGGTTCTTAAGAACATGCTCTTGCTTGATGACTTTATTGTGTACAGTCCATCTGGTTCTTCTCTTGCAAACGTAAGAAATGCCTGTGTGTACTTTTCACAACTTATTGGTAAGCCTATTAAGATTGTTAACAGTGATTTACTTGAAGACCTCTCTGTAGACTTTAAAGGAGCACTTTTCAATGCTAAGAAGAATGTAATTAAGAATTCTTTCAATGTAGACGTTTCGGAATGTAAAAATCTTGATGAGTGCTATAAAGCTTGCAATCTTGATGTGTCATTTTCAACATTTGAAATGGCTGTCAATAATGCTCATAGATTTGGTATTTTGATTACTGACCGTTCTTTTAACAATTTTTGGCCATCAAAAGTCAAACCTGGTTCATCTGGTGTTTCAGCCATGGACATTGGTAAGTGTATGACCTCTGATGCTAAAATTGTTAATGCTAAAGTTTTGACTCAACGTGGTAAAAGTGTTGTTTGGCTTAGTCAAGATTTTGCTGCACTTAGCTCAACTGCCCAGAAAGTTTTGGTTAAAACTTTTGTAGAAGAAGGTGTCAACTTTTCACTCACATTCAATGCTGTAGGTTCAGATGATGATCTTCCTTATGAAAGATTCACTGAATCTGTGCCTCCAAAAAGTGGTTCAGGCTTTTTCGATGTAATCAAACAGCTTAAACAAATTGTGATGTTAGTTCTTGGTTTCATCTTTATCTATGGTTTGTGCTCTGTCTACAGTGTTGCTACACAGTCCTACATTGAATCTGCTGAAGGTTATGACTACATGGTTATTAAGAATGGAATTGTTCAACCTTTTGACGACACCATTTCATGTGTTCATAACACTTACAAAGGATTTGGTGAATGGTTTAAAGCTAAGTACGGTTTTATCCCTACTTTTGCCAAAGCATGCCCAATTGTTGTAGGAACTGTTTTTGATCTTGAAAACATGAGACCAATTCCTGATGTGCCTGCATATGTAGCTCTTGTTGGTAGATCTCTTGTTTTTGCTATTAATGCTGCTTTTGGTGTTACTAATATGTGCTATGATCATACTGGCAATGCAGTGAGTAAGGATTCTTACTTCGACACTTGTGTGTTTAATGCTGCATGCACCACTCTTACAGGTCTTGGTGGTACAATTGTTTATTGTGCAAAACAAGGTCTAGTTGAAGGTGCTAAGCTCTATAGTGATCTTATGCCTGACTATTATTATGAGCACGCTAGTGGTAACATGGTTAAATTGCCAGCAATTATTAGAGGACTTGGTCTACGGTTTGTAAAAACACAGGCTACGACTTACTGCAGAGTAGGAGAGTGTATTGACAGCAAAGCTGGTTTTTGCTTTGGTGGTGATAACTGGTTTGTCTATGACAAAGAGTTTGGTAATGGGTACATTTGTGGTAATTCTGTTTTAGGATTCCTTAAGAATGTCTTCAGACTCTTTAACTCTAACATGTCTGTGGTAGCCACATCAGGTGCGATGCTTGTTAACATTATCATTGCTTGCCTGGCTATTGCAATGTGTTATGGTGTTCTTAAATTTAAGAAAATATTTGGTGACTGCACTCTTCTGATTGTTATGATTATTGTTACACTTGTTGTAAACAATGTGTCTTATTTTGTCACTCAAAACACATTCTTTATGATTATTTATGCCATTGTTTATTACTTTACAACTAGGAAGCTTGCATACCCAGGCGTCCTTGATGCTGGGTTTATTATTGCTTACATTAACATGGCTCCATGGTATGTGATTACTGCATACATCTTAGTGTTCCTCTATGACTCACTTCCTTCACTGTTCAAACTTAAGGTTTCAACAAACCTTTTTGAAGGTGACAAATTTGTGGGTAACTTTGAATCTGCCGCTATGGGTACTTTTGTTATTGATATGCGTTCATATGAAACTATTGTTAATTCTACTCCTATTGATAGAATTAAATCATATGCTAACAGCTTCAATAAATATAAGTACTACACAGGTTCAATGGGAGAGGCTGACTACAGAATGGCTTGCTATGCTCATCTTGGTAAAGCTCTTATGGACTATTCTGTTAACAGAACAGACATGCTTTACACACCTCCTACTGTTAGTGTTAATTCCACACTTCAGTCCGGGTTGAGGAAAATGGCACAGCCTAGTGGTCTTGTAGAGCCTTGCATTGTAAGAGTTTCCTATGGTAACAATGTGCTTAATGGTTTATGGTTAGGAGATGAGGTCTTTTGTCCTAGACATGTCATTGCTAGTGATACCACACGTGTTATCAACTATGAAAATGAAATGTCCAGTGTGAGACTTCATAATTTTTCAGTTTCTAAAAATAATGTGTTTTTGGGTGTTGTGTCTGCCAAATATAAGGGTGTGAATCTCGTACTAAAAGTCAACCAGGTTAATCCTAACACACCAGAACATAAATTTAAGTCTATTAAAGCTGGTGAAAGTTTTAACATTCTTGCTTGTTATGAGGGATGTCCTGGTAGTGTTTATGGTGTTAACATGAGAAGCCAAGGTACCATTAAAGGTTCTTTTATTGCTGGTACTTGTGGATCAGTAGGTTATGTTTTGGAAAATGGAATTCTCTATTTTGTATACATGCATCACCTAGAACTTGGAAATGGCTCACATGTTGGTTCCAATTTTGAAGGAGAAATGTATGGTGGTTATGAAGATCAACCTAGCATGCAACTTGAAGGTACTAATGTCATGTCATCAGATAATGTGGTTGCATTTTTGTATGCTGCACTTATTAATGGTGAAAGGTGGTTTGTTACAAACACATCAATGTCATTAGAATCATACAATACATGGGCCAAAACTAACAGTTTCACAGAACTCTCTTCAACTGATGCATTTAGCATGTTGGCTGCGAAAACTGGTCAAAGTGTTGAGAAATTGCTAGATTGCATTGTAAGACTCAACAAAGGTTTTGGAGGTCGTACCATACTTTCTTATGGCTCACTGTGTGATGAGTTCACCCCAACTGAAGTCATAAGGCAAATGTATGGTGTAAATCTTCAAGCTGGTAAAGTAAAATCTTTCTTTTACCCTATTGTGACTGCAATGACAATTCTCTTTGCTTTTTGGCTTGAATTTTTCATGTACACACCCTTTACTTGGATTAACCCAGCTTTTGTTAGCTTTGTATTGGCTGTTACAACTTTGGTTTCGACTGTTTTTGTTTCAGGAATTAAACATAAGATGTTGTTCTTTATGTCTTTTGTTCTGCCTAGCGTTGTTCTTGTAACAGCACACAACTTATTCTGGGACTTTTCTTACTATGAAAGTCTTCAGTCAATTGTTGAAAATACTAACACTATGTTCTTGCCTGTTGACATGCAAGGTGTCATGCTCACAGTGTTTTGTTTTATTGTCTTTGTCACATACAGTGTTAGATTCTTCACTTGTAAACAATCATGGTTCTCACTCGCCGTGACAACTGTTCTTGTGATTTTTAACATGTTTAAAATTTTTGGAACATCTGATGAACCATGGACTGAAAACCAAATTGCTTTCTGCTTTGTGAACATGCTTACTATGATCGTCAGTCTTACTACAAAAGATTGGGTTGTTGTTGTTGCATCATACAGAGTCGCTTACTATATTGTTGTATGTGTAATGCCAGCTGCTTTTGTGTCTGACTTTGGCTTTATGAAGTGTATTAGCATTGTTTACATGGCTTGTGGTTATTTGTTCTGCTGTTATTATGGTATCCTCTATTGGGTTAACAGATTTACATGCATGACTTGTGGTGTTTATCAATTCACTGTGTCTGCAGCTGAACTTAAATACATGACTGCTAACAACCTTTCTGCACCTAAGAATGCGTATGACGCTATGATTCTTAGTGCTAAATTGATTGGTGTTGGAGGTAAGAGAAACATTAAAATTTCAACTGTACAGTCAAAACTTACAGAGATGAAATGTACAAATGTAGTCTTGCTCGGTCTTTTGTCTAAAATGCATGTTGAGTCTAACTCAAAAGAGTGGAACTATTGTGTAGGACTACACAATGAGATCAACCTTTGTGACGATCCTGAGATTGTTCTTGAAAAGTTGTTAGCTCTCATTGCATTCTTTTTGTCCAAACACAATACTTGTGACCTTAGCGAACTTATTGAATCATACTTTGAGAACACTACCATACTTCAGAGTGTGGCTTCAGCTTATGCTGCACTGCCTAGCTGGATTGCATTTGAAAAACGTCGCGCTGATCTTGAAGAGGCTAAGAAAAATGATGTTAGCCCTCAAATTTTGAAACAGCTTACCAAGGCATTTAATATTGCCAAAAGTGATTTTGAGCGCGAAGCTTCAGTTCAAAAGAAGCTTGACAAAATGGCTGAGCAGGCTGCTGCTAGTATGTACAAAGAAGCACGAGCTGTGGATAGAAAATCAAAAGTCGTTTCTGCTATGCATAGCCTACTTTTTGGTATGCTTAAGAAACTCGATATGTCTAGTGTCAACACTATTATTGACCAGGCTCGTAATGGTGTTTTACCTTTAAGTATCATTCCAGCTGCATCAGCTACAAGACTTGTTGTTGTAACACCTAGTCTTGAAGTGTTTTCCAGGATTAGGCAAGAAAACAATGTTCATTATGCTGGTGCTATTTGGACTATCGTTGAAGTCAAAGACGCTAATGGTTCACATGTTCATCTTAAAGAAGTCACTGCTGCTAATGAATTAAATCTTACTTGGCCGTTGAGCATTACTTGTGAGAGAACCACAAAGCTTCAGAACAATGAAATTATGCCAGGTAAACTTAAAGAAAGAGCGGTCAAAGCTTCAGCCATTTTAGATGGTGAAGCTTTCGGCAGTGGAAAGGCTCTTATGGCAGCTGAAAGTGGCAAAAGCTTTATGTATGCATTTATAGCCTCAGACAACAATCTTAAGTATGTCAAATGGGAGAGCAATAATGATATCATACCTATTGAACTTGAAGCTCCATTGCGTTTCTATGTTGATGGCGTTAATGGTCCTGAAGTCAAGTATTTGTACTTCGTCAAGAACTTAAACACTCTTAGACGTGGTGCCGTTCTTGGTTATATCGGTGCAACAGTTCGTCTGCAAGCTGGTAAACCCACTGAACATCCATCTAATAGTAGTTTATTGACATTGTGTGCTTTTGCACCTGATCCTGCTAAAGCATATGTTGATGCTGTTAAAAGAGGTATGCAACCAGTTAATAACTGTGTAAAAATGCTCTCAAATGGTGCTGGTAATGGTATGGCTATTACAAATGGTGTCGAAGCTAACACACAACAAGATTCTTATGGTGGCGCTTCTGTTTGCATTTACTGCAGATGCCATGTGGAACATCCCGCTATTGATGGAATGTGCCGTTACAAAGGCAAATTTGTACAAATACCAACTGGCACTCAAGACCCCATTCGCTTTTGTATTGAAAATGAAGTTTGTGTTGTCTGTGGCTGTTGGCTTAACAATGGTTGCATGTGCGATCGTACTTCTATGCAGAGTTCTACTGTTGATCAAAGTTATTTAAACGAGTGCGGGGTTCTAGTGCAGCTCGACTAGAACCCTGTAATGGTACTGATCCAGACCATGTTAGTAGAGCTTTTGACATCTACAACAAAGATGTTGCGTGTATTGGTAAGTTCCTTAAGACAAACTGTTCAAGATTTAGGAATTTGGACAAACATGATGCCTACTACATTGTCAAACGTTGTACAAAGACCGTTATGGACCATGAGCAAGTCTGTTATAACGATCTTAAAGATTCTGGTGCTGTTGCTGAGCATGACTTCTTTACTTACAAAGAAGGCAGATGTGAATTCGGCAACATCGCACGTAGGGATCTTACAAAGTACACAATGATGGATCTTTGTTATGCTATTAGAAATTTTGATGAAAAGAACTGTGAAGTTCTCAAAGAAATACTCGTGACAGTAGGTGCTTGCACTGAAGAATTCTTTGAAAACAAAGATTGGTTTGACCCAGTTGAAAATGAAGCCATACATGAAGTTTATGCAAAACTTGGACCCATTGTAGCCAATGCTATGCTTAAATGCGTTGCTTTTTGCGATGCCATAGTGGAAAAGGGCTATATAGGTATTATAACACTTGACAACCAAGATCTTAATGGCAATTTCTACGATTTCGGAGATTTCGTAAAAACTGCTCCAGGTTTTGGTTGTGCTTGTGTTACATCATATTATTCTTATATGATGCCTTTAATGGGAATGACTTCATGCTTAGAGTCTGAAAACTTTGTGAAAAGTGAAATTTATGGTTCTGACTATAAGCAGTATGATTTACTGGCTTATGATTTCACTGAACATAAAGAGTACCTTTTCCAGAAATACTTTAAGTACTGGGATCGCACGTATCACCCAAATTGTTCTGATTGTACTAGTGATGATTGTATCATTCATTGTGCTAATTTCAACACACTATTTTCTATGACAATACCAATGACTGCTTTCGGACCACTTGTCCGTAAAGTTCACATTGATGGTGTGCCAGTTGTTGTTACTGCAGGTTACCACTTTAAACAACTTGGTATTGTATGGAATCTTGATGTGAAATTGGACACAATGAAGTTGACTATGACAGATCTGCTTAGATTTGTCACAGATCCTACACTTCTTGTAGCATCAAGCCCTGCATTGTTAGATCAACGCACTGTCTGTTTCTCCATTGCAGCTTTGAGTACTGGTGTTACATATCAGACAGTAAAGCCAGGTCACTTTAACAAAGATTTCTACGATTTTATAACAGAGCGTGGATTCTTTGAAGAGGGATCTGAATTAACATTAAAACACTTTTTCTTTGCACAGGGCGGTGAAGCTGCTATGACAGACTTCAATTACTATCGCTACAATAGAGTCACAGTACTAGACATTTGCCAAGCTCAGTTTGTTTACAAAATAGTTGGCAAATATTTTGAATGCTATGATGGTGGGTGCATTAATGCTCGTGAAGTTGTTGTTACAAACTATGATAAGAGTGCTGGTTATCCTTTGAACAAATTTGGTAAAGCTAGACTTTACTATGAAACTCTGTCATATGAAGAGCAGGATGCACTTTTTGCTTTAACAAAGAGAAATGTTCTACCCACAATGACTCAGATGAATTTGAAATATGCTATTTCTGGAAAGGCTAGAGCTCGTACAGTAGGAGGAGTTTCACTTCTTTCTACCATGACTACGAGACAATACCACCAGAAGCATTTGAAGTCAATTGCTGCAACACGCAATGCCACTGTGGTTATTGGCTCAACCAAGTTTTATGGTGGTTGGGATAACATGCTTAAAAATTTAATGCGTGATGTTGATAATGGTTGTTTGATGGGATGGGACTATCCTAAGTGTGACCGCGCTTTACCTAATATGATCAGAATGGCATCTGCCATGATATTAGGTTCTAAGCATGTTGGTTGTTGTACACATAGTGATAGATTCTATCGCCTCTCCAATGAGTTAGCTCAAGTACTCACAGAAGTTGTGCATTGCACGGGTGGTTTTTACTTTAAACCTGGTGGTACAACTAGCGGTGATGGTACTACAGCTTATGCTAACTCAGCTTTTAACATCTTTCAAGCTGTTTCTGCTAATGTTAATAAGCTTTTGGGAGTCGATTCAAACGCTTGTAACAATGTTACAGTAAAATCCATACAACGTAAAATCTACGATAATTGTTATCGTAGTAGCAGCATTGATGAAGAATTTGTTGTTGAATACTTCAGTTATTTGAGAAAACACTTTTCTATGATGATTCTATCTGATGATGGAGTTGTGTGCTACAACAAAGATTATGCAGATCTAGGTTATGTAGCTGATATCAATGCTTTTAAAGCAACGCTCTATTATCAGAATAATGTCTTTATGTCCACTTCTAAGTGTTGGGTAGAACCAGATCTTAATGTTGGACCACATGAATTTTGTTCACAGCACACATTGCAAATTGTTGGACCTGATGGAGACTATTACCTTCCCTATCCAGACCCATCTAGAATTTTGTCAGCTGGTGTGTTTGTTGATGACATAGTTAAAACAGATAATGTTATTATGTTAGAACGTTATGTGTCATTGGCTATTGATGCATACCCACTCACAAAACATCCTAAGCCTGCTTATCAAAAAGTATTTTACACCCTGCTTGATTGGGTTAAACATTTACAGAAAAATTTGAATGCAGGTGTTCTTGATTCCTTCTCAGTTACAATGCTAGAAGAAGGTCAAGATAAGTTCTGGAGTGAAGAGTTTTATGCTAGCCTCTATGAAAAATCTACTGTTTTGCAAGCTGCAGGCATGTGTGTTGTATGTGGTTCACAAACTGTATTGCGTTGTGGAGACTGTCTTAGGAGACCACTTTTGTGTACGAAATGTGCTTATGACCATGTTATGGGAACAAAGCACAAATTCATTATGTCTATCACACCATACGTGTGTAGTTTTAATGGTTGTAATGTCAATGATGTTACAAAGTTGTTTTTAGGTGGTCTTAGTTATTATTGTATGGACCACAAACCACAGTTGTCATTCCCACTCTGTGCTAATGGCAATGTTTTTGGTTTATACAAAAGTAGTGCAGTCGGTTCAGAGGATGTTGAAGACTTCAACAAACTCGCAGTTTCCGATTGGACTAATGTGGAAGACTACAAACTTGCTAACAATGTCAAGGAATCCCTGAAAATTTTCGCTGCTGAAACTGTGAAAGCTAAGGAGGAGTCTGTTAAATCTGAATATGCCTATGCCATATTAAAGGAGGTTATCGGCCCTAAGGAAATTGTACTCCAATGGGAAGCTTCTAAGACTAAGCCTCCACTTAACAGAAATTCAGTTTTCACGTGTTTTCAGATAAGTAAGGATACTAAAATTCAATTAGGTGAATTTGTGTTTGAGCAATCTGAGTACGGTAGTGATTCTGTTTATTACAAGAGCACAAGTACTTACAAATTGACACCAGGTATGATTTTTGTGTTGACTTCTCATAATGTGAGTCCTCTTAAAGCCACAATTTTGGTCAACCAGGAAAAGTACAATACCATATCTAAGCTCTATCCTGTCTTTAACATAGCGGAAGCCTATAATACACTGGTCCCTTACTATCAAATGATAGGTAAGCAGAAATTTACAACTATCCAAGGTCCTCCTGGTAGCGGTAAATCTCATTGTGTTATAGGTTTGGGTTTGTATTATCCTCAAGCCAGAATAGTCTACACAGCATGTTCCCATGCTGCTGTGGACGCTTTATGTGAAAAAGCGGCCAAGAACTTCAATGTTGATAGATGTTCAAGGATAATACCTCAAAGAATCAGAGTTGATTGTTACACAGGTTTTAAGCCTAACAACACTAATGCTCAGTACTTGTTTTGTACTGTTAATGCTCTACCAGAGGCAAGTTGTGACATTGTTGTAGTCGATGAGGTCTCCATGTGTACTAACTATGACCTTAGTGTCATAAATAGTAGACTGAGTTACAAGCATATTGTCTATGTAGGAGACCCTCAACAATTACCAGCTCCTAGAACCTTGATTAATAAGGGTGTGCTTCAACCACAGGATTATAATGTGGTAACTCAAAGAATGTGCACATTAGGACCTGATGTTTTCTTACACAAATGTTATAGATGCCCAGCTGAGATTGTTAAGACAGTCTCTGCACTTGTTTATGAAAATAAATTTGTACCTGTCAACCCTGAATCAAAGCAGTGCTTCAAGATGTTTGTAAAAGGTCAGGTTCAGATTGAATCAAACTCTTCTATAAACCATAAGCAACTAGAGGTTGTCAAGGCATTCTTAGCACATAATCCAAAATGGCGTAAAGCTGTTTTTATCTCACCCTATAATAGTCAAAACTATGTTGCAAGACGTCTTCTTGGTTTACAAACTCAAACTGTAGACTCTGCACAAGGTAGTGAGTATGATTATGTGATTTACACACAGACTTCTGACACACAGCATGCTACTAATGTCAATAGATTTAATGTTGCCATTACTAGAGCAAAAGTTGGTATTCTCTGTATCATGTGTGATAGGAGCATGTATGATAACCTTGACTTCTATGAACTCAAGGATTCTAAGATTGGCTTACAAGCAAAACCTGAAACATGTGGTTTGTTTAAAGATTGTTCAAAGAATGAGCAATACATACCACCTGCATATGCAACAACATATATGAGCTTGTCTGATAATTTTAAAACAAGCGATGGTCTAGCTGTTAACATCGGTACAAAAGATGTTAAATATGCTAACGTCATTTCATATATGGGATTCAGGTTTGAAGCCAATATACCAGGCTATCACACATTGTTTTGCACGCGAGACTTTGCTATGCGTAATGTTAGAGCATGGCTTGGATTTGACGTTGAAGGTGCACATGTCTGTGGTGATAATGTTGGAACTAATGTACCATTACAGCTGGGTTTCTCTAATGGTGTTGATTTTGTAGTACAAACTGAAGGATGTGTTATTACTGAAAAAGGTAATAGCATTGAGGTTGTAAAAGCACGAGCACCACCAGGTGAGCAATTTGCACACTTGATTCCACTTATGAGAAAAGGTCAACCCTGGCACATTGTTAGACGCCGTATAGTGCAGATGGTCTGTGACTATTTTGATGGCTTATCAGACATTCTGATCTTTGTGCTTTGGGCTGGTGGTCTTGAACTTACAACTATGAGATACTTTGTTAAGATTGGAAAACCACAAAAATGTGAATGCGGCAAAACTGCAACTTGTTATAGTAGCTCTCAATGTGTCTATGCTTGTTTCAAGCATGCATTGGGCTGTGATTATTTATATACCCCCTATGGCATTGACATACAACAATGGGGCTACACAGGTTCTTTGAGCATGAATCATCATGAAGTTTGCAACATTCATAGAAATGAGCATGTAGCTAGTGGTGATGCTATCATGACTAGGTGCCTTGCTATACATGATTGTTTTGTCAAACGTGTTGATTGGTCTATTGTGTACCCTTTTATTGACAATGAGGAAAAGATCAATAAAGCTGGTCGCATTGTGCAATCACATGTCATGAAAGCTGCTCTGAAAATTTTTAACCCTGCTGCAATTCACGATGTGGGCAATCCCAAAGGCATCCGTTGTGCTACAACACCTATACCATGGTTCTGTTATGACAGAGATCCTATTAATAACAATGTTAGATGTCTGGAGTATGACTATATGGTACATGGTCAAATGAATGGTCTTATGTTATTTTGGAACTGCAATGTAGACATGTACCCAGAGTTCTCAATTGTTTGTAGATTTGATACTCGCACGCGCTCTAAATTGTCTTTAGAAGGTTGTAATGGTGGTGCATTGTATGTTAATAACCATGCTTTCCACACACCAGCTTATGATAGAAGAGCTTTTGCTAAGCTTAAACCTATGCCATTCTTTTACTATGATGATAGTAATTGTGAACTTGTTGATGGACAACCTAATTATGTGCCACTCAAGTCTAATGTTTGCATAACAAAATGCAATATTGGTGGTGCTGTCTGCAAGAAGCATGCTGCTCTTTACAGAGCGTATGTTGAGGATTACAACATGTTTATGCAGGCTGGTTTTACAATATGGTGTCCTCAAAATTTCGATACTTATATGCTTTGGCATGGTTTTGTTAATAGCAAAGCACTCCAGAGTCTAGAAAATGTGGCTTTTAATGTCGTTAAAAAAGGTGCCTTCACAGGTCTAAAAGGAGACTTACCAACTGCTGTTATAGCTGACAAGATAATGGTGAGAGAGGGACCTACTGACAAGTGTATCTTTACAAACAAGACTAGTTTACCTACAAATGTAGCTTTTGAGCTATATGCAAAACGTAAACTTGGACTCACACCTCCATTAACAATACTTAGAAATTTGGGTGTTGTCGCAACATACAAATTTGTGTTGTGGGATTATGAAGCTGAATGTCCTTTCTCAAATTTCACCAAACAAGTGTGCTCGTATACTGACCTTGATAGTGAAGTTGTAACATGTTTTGATAATAGTATTGCTGGTTCTTTTGAACGCTTTACTACTACAAAAGATGCAGTGCTTATTTCTAATAACGCTGTGAAGGGACTTAGTGCCATTAAATTACAATATGGCTTTTTGAATGATCTACCTGTAAGTACTGTTGGAAACAAACCTGTCACATGGTATATCTATGTGCGCAAGAATGGTGAGTACGTCGAACAAATTGATAGTTACTACACACAGGGACGTACTTTTGAAACCTTTAAACCTCGTAGTACAATGGAAGAAGATTTTCTTAGTATGGATACTACACTCTTCATCCAAAAGTATGGTCTTGAGGATTATGGTTTTGAACACGTTGTATTTGGAGATGTTTCTAAAACTACCATTGGTGGTATGCATCTCCTCATATCTCAAGTGCGCCTTGCAAAAATGGGTTTGTTTTCTGTGCAAGAATTTATGACCAATTCTGACAGTACACTGAAAAGTTGTTGTATTACATATGCTGATGATCCTTCTTCTAAGAATGTGTGCACTTATATGGACATACTCTTGGACGATTTTGTGACTATCATTAAGAGCTTAGATCTTAATGTTGTGTCCAAAGTTGTGGATGTTATTGTAGATTGTAAGGCATGGAGGTGGATGTTGTGGTGTGAAAATTCACAAATTAAAACCTTCTATCCACAACTCCAATCTGCTGAATGGAATCCTGGCTATAGCATGCCTACATTGTACAAAATCCAGCGTATGTGTCTCGAACGGTGTAATCTCTACAATTATGGTGCACAAGTGAAACTACCTGATGGCATTACTACTAATGTCGTTAAGTATACCCAGTTGTGTCAATACCTTAACACTACTACTTTGTGTGTACCACACAAAATGCGAGTCTTGCATTTAGGAGCTGCTGGTGCATCTGGTGTTGCTCCTGGTAGTACTGTATTAAGAAGGTGGTTACCAGATGATGCCATATTGGTTGATAACGATTTGAGAGATTACGTTTCCGACGCAGACTTCAGTGTTACAGGTGATTGTACTAGTCTTTACATTGAAGACAAGTTTGATTTGCTTATCTCTGATTTATATGACGGCTCCACAAAGTCAATTGACGGTGAAAATACGTCAAAGGATGGTTTCTTTACTTATATCAATGGTTTTATTAAAGAGAAGCTATCACTTGGTGGGTCTGCTGCCATTAAAATCACAGAATTTAGTTGGAATAAAGATTTATATGAATTGATTCAAAGATTTGAGTATTGGACTGTGTTTTGTACAAGTGTTAACACCTCATCGTCAGAAGGTTTTCTGATTGGTATTAACTACTTAGGACCATACTGTGAAAAAGCAATAGTAGATGGAAATATAATGCATGCCAATTATATATTTTGGAGAAATTCTACAATTATGGCTCTATCACATAATTCAGTCCTAGATACTCCCAAGTTTAAGTGCCGGTGTAATAACGCACTTATTGTTAATTTAAAAGAAAAAGAATTGAATGAAATGGTTGTTGGATTACTAAGGAAAGGTAAGTTGCTCATTAGAAACAATGGAAAACTACTAAACTTTGGTAATCACTTGGTTAATGTGCCATGA
Protein
MSSKQFKILVNEDYQVNVPSLPIRDVLQEIKYCYRNGFEGYVFVPEYCRDLVDCDRKDHYVIGVLGNGISDLKPVLLTEPSVMLQGFIVKAICNGALEDFDLKIARTGRGAIYVDQYMCGADGKPVIEGDFKDYFGDEDIIEFEGEEYHCAWTTVRDEKLLNQQTLFTIQEIQYNLDIPHKLPNCATRHVAPPVKKNSKIVLSEDYKKLYEIFGSPFMGNGDCLSKCFDTLHFIAATLRCPCGAESSGVGDWTGFKTACCGLVGKVLGVTLGDIKPGDAVVTSMSAGKGVKFFANCVLQHAGDVENVSVWKVIKTFTVDETVCTPDFEGELNDFIKPESKSPTACSIKRAFITGEIDDAVHDCIITGKLDLSTNLFGNVGLLFKKTPWFVQKCGALFVDAWKVVEELLGSLKLTYKQIYEVVASLCTSAFTIVNYKPTFVVLDNRVKDLVDKCVNILVKAFDVFTQTITIAGIEAKCFVLGAKYLLFNNALVKLVSVKILGKKQKGLESAFFATSLVGATVNVTPKRTETATISLNKVDDVVAPGEGYIVIVGDMAFYKSGEYYFMMASPDSVLINNVFKAARVPSYDIVYDVDDDTKGKMTAKLGSSFEYDGDIDAAVTKVNELLIEFKQQSLCFRALKDDKSIFVEAYLKKYKMPACLAKHIGLWNIIKKDSCKKGFLSLFNHLNELEDVKETNVQAIKNILCPDLLLDLDYGAIWYKCMPSCSDLSVLGSVQLLIGNGVKVVCDGCKVFANQLSNGYNKLCNAARTDIEIGGIPFSTFKTPTNTFIEMTDAIYSVIEQGKALSFGNADVPVLDNGTISTDDWSEPILLEPAEYVKPKNNGNVIVIAGYTFYKDEDEHFYPYGSGKIVQRMYNKMGGGDKTVSFSEEVDVQEIAPVTRVNLEFEFDNEIVTGVLEQAIGTRYKFTGTTWEEFEDSISEELDAIFDTLANQGVELEGYFIYDTCGGFDFKNPDGIMISQYDINNIADEKSETGASSEEEEVESVEEDAENEIVEASEAIEETSSQEEVETVEVEDITSAEDVEIVEVSAKDDPWAAAVDVQEAEHVKPSLPPFKTTNLNGKIILKQQDNNCWINACCYQLQAFDFFNNEAWEKFKKGDVMDFVNLCYAATTLERGHSGDAEYLLELMLNDYSTAKIVLVAKCGCGEKEIVLERTVFKLTPLKDEFNYGVCGECMQINRCKVASVEGSGLFVHDCIDKQTPTSQFIVKPIMHAVYTGTTQNGHYMVDDIEHDYCVDGMGIKPRKKRLYTSTLFINANVMTRVEKPKQQPKVEKVEQQPEIEEKKPSIEKEEVQSPKNDDLILPFYKAGKLSFYQGDLDVLINFLEPDVIVNAANGDLKHMGGVARAIDVFTSGKLTERVMDYLKKNKSIAPGNAVFFENVIENLSVLNAVGPRNGDSRIEGKLNNVYKAIAKCEGKILTPLISVGIFSVKLEMSLQCLLKTVNDRELNVFVYTDQERQAIENFFSGSIPVKVTEDNVNHERVSVSFDKTYGEQLKGTVVIKDKDVTNQLPSAFDVGQKVVKAIDVDWQAHYGFHDAAAFSASSHDAYKFEVVTHSNFIVHKQTDNNCWINAICLALQRLKPQWKFPGVRGLWNEFLERKTQGFVHMLYHISGVKKGEPGDAELTLHKLGDLMDNDCEIIVTHTTACDKCSKVEKFTGPVVAAPLAIHGTDETCVHGVSVNVKVTQIKGTVAITSLIGPIIGEVLEATGYICYRGSSKNGHYTYYDNRNGLMIDAEKAYHFNKDLLQVTTAIASNFVVKKPQVEEKPKTRVFNRVDEPPKTIVQEQKLLAIESGADYALTEFGRYADMFFMAGDKILRFLLEVFKYLLVLFMCLRSTKMPKVKVKPPHAFKDLGAKVRTLNYMRQLNKPAVWRYAKLVLLLIAIYNFFYLFVSIPVVHKLTCSGAVQAYKNSSFVKSEVCGNSILCKACLASYDELADFQHLQVAWDFKSDPLWNKLVQLSYFVFLAVFGNNYVRCFLMYFVSQYLNLWLSHFGYVEHSWFLHVVSFESISAEFVIIVILVKAVLALKHIVFSCSNPSCKTCSKTARQTRIPIQVVVNGSMKTVYVHANGTGKLCKKHNFYCKNCDSYGFENTFICDEIVRDLSNSVKQTVYATDRSHQEVTKVECSDGFYRFYVGDEFTSYDYDVKHKKYSSQEVLKNMLLLDDFIVYSPSGSSLANVRNACVYFSQLIGKPIKIVNSDLLEDLSVDFKGALFNAKKNVIKNSFNVDVSECKNLDECYKACNLDVSFSTFEMAVNNAHRFGILITDRSFNNFWPSKVKPGSSGVSAMDIGKCMTSDAKIVNAKVLTQRGKSVVWLSQDFAALSSTAQKVLVKTFVEEGVNFSLTFNAVGSDDDLPYERFTESVPPKSGSGFFDVIKQLKQIVMLVLGFIFIYGLCSVYSVATQSYIESAEGYDYMVIKNGIVQPFDDTISCVHNTYKGFGEWFKAKYGFIPTFAKACPIVVGTVFDLENMRPIPDVPAYVALVGRSLVFAINAAFGVTNMCYDHTGNAVSKDSYFDTCVFNAACTTLTGLGGTIVYCAKQGLVEGAKLYSDLMPDYYYEHASGNMVKLPAIIRGLGLRFVKTQATTYCRVGECIDSKAGFCFGGDNWFVYDKEFGNGYICGNSVLGFLKNVFRLFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTLLIVMIIVTLVVNNVSYFVTQNTFFMIIYAIVYYFTTRKLAYPGVLDAGFIIAYINMAPWYVITAYILVFLYDSLPSLFKLKVSTNLFEGDKFVGNFESAAMGTFVIDMRSYETIVNSTPIDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYSVNRTDMLYTPPTVSVNSTLQSGLRKMAQPSGLVEPCIVRVSYGNNVLNGLWLGDEVFCPRHVIASDTTRVINYENEMSSVRLHNFSVSKNNVFLGVVSAKYKGVNLVLKVNQVNPNTPEHKFKSIKAGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYVLENGILYFVYMHHLELGNGSHVGSNFEGEMYGGYEDQPSMQLEGTNVMSSDNVVAFLYAALINGERWFVTNTSMSLESYNTWAKTNSFTELSSTDAFSMLAAKTGQSVEKLLDCIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGVNLQAGKVKSFFYPIVTAMTILFAFWLEFFMYTPFTWINPAFVSFVLAVTTLVSTVFVSGIKHKMLFFMSFVLPSVVLVTAHNLFWDFSYYESLQSIVENTNTMFLPVDMQGVMLTVFCFIVFVTYSVRFFTCKQSWFSLAVTTVLVIFNMFKIFGTSDEPWTENQIAFCFVNMLTMIVSLTTKDWVVVVASYRVAYYIVVCVMPAAFVSDFGFMKCISIVYMACGYLFCCYYGILYWVNRFTCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQSKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCDLSELIESYFENTTILQSVASAYAALPSWIAFEKRRADLEEAKKNDVSPQILKQLTKAFNIAKSDFEREASVQKKLDKMAEQAAASMYKEARAVDRKSKVVSAMHSLLFGMLKKLDMSSVNTIIDQARNGVLPLSIIPAASATRLVVVTPSLEVFSRIRQENNVHYAGAIWTIVEVKDANGSHVHLKEVTAANELNLTWPLSITCERTTKLQNNEIMPGKLKERAVKASAILDGEAFGSGKALMAAESGKSFMYAFIASDNNLKYVKWESNNDIIPIELEAPLRFYVDGVNGPEVKYLYFVKNLNTLRRGAVLGYIGATVRLQAGKPTEHPSNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKMLSNGAGNGMAITNGVEANTQQDSYGGASVCIYCRCHVEHPAIDGMCRYKGKFVQIPTGTQDPIRFCIENEVCVVCGCWLNNGCMCDRTSMQSSTVDQSYLKRVRGSSAARLEPCNGTDPDHVSRAFDIYNKDVACIGKFLKTNCSRFRNLDKHDAYYIVKRCTKTVMDHEQVCYNDLKDSGAVAEHDFFTYKEGRCEFGNIARRDLTKYTMMDLCYAIRNFDEKNCEVLKEILVTVGACTEEFFENKDWFDPVENEAIHEVYAKLGPIVANAMLKCVAFCDAIVEKGYIGIITLDNQDLNGNFYDFGDFVKTAPGFGCACVTSYYSYMMPLMGMTSCLESENFVKSEIYGSDYKQYDLLAYDFTEHKEYLFQKYFKYWDRTYHPNCSDCTSDDCIIHCANFNTLFSMTIPMTAFGPLVRKVHIDGVPVVVTAGYHFKQLGIVWNLDVKLDTMKLTMTDLLRFVTDPTLLVASSPALLDQRTVCFSIAALSTGVTYQTVKPGHFNKDFYDFITERGFFEEGSELTLKHFFFAQGGEAAMTDFNYYRYNRVTVLDICQAQFVYKIVGKYFECYDGGCINAREVVVTNYDKSAGYPLNKFGKARLYYETLSYEEQDALFALTKRNVLPTMTQMNLKYAISGKARARTVGGVSLLSTMTTRQYHQKHLKSIAATRNATVVIGSTKFYGGWDNMLKNLMRDVDNGCLMGWDYPKCDRALPNMIRMASAMILGSKHVGCCTHSDRFYRLSNELAQVLTEVVHCTGGFYFKPGGTTSGDGTTAYANSAFNIFQAVSANVNKLLGVDSNACNNVTVKSIQRKIYDNCYRSSSIDEEFVVEYFSYLRKHFSMMILSDDGVVCYNKDYADLGYVADINAFKATLYYQNNVFMSTSKCWVEPDLNVGPHEFCSQHTLQIVGPDGDYYLPYPDPSRILSAGVFVDDIVKTDNVIMLERYVSLAIDAYPLTKHPKPAYQKVFYTLLDWVKHLQKNLNAGVLDSFSVTMLEEGQDKFWSEEFYASLYEKSTVLQAAGMCVVCGSQTVLRCGDCLRRPLLCTKCAYDHVMGTKHKFIMSITPYVCSFNGCNVNDVTKLFLGGLSYYCMDHKPQLSFPLCANGNVFGLYKSSAVGSEDVEDFNKLAVSDWTNVEDYKLANNVKESLKIFAAETVKAKEESVKSEYAYAILKEVIGPKEIVLQWEASKTKPPLNRNSVFTCFQISKDTKIQLGEFVFEQSEYGSDSVYYKSTSTYKLTPGMIFVLTSHNVSPLKATILVNQEKYNTISKLYPVFNIAEAYNTLVPYYQMIGKQKFTTIQGPPGSGKSHCVIGLGLYYPQARIVYTACSHAAVDALCEKAAKNFNVDRCSRIIPQRIRVDCYTGFKPNNTNAQYLFCTVNALPEASCDIVVVDEVSMCTNYDLSVINSRLSYKHIVYVGDPQQLPAPRTLINKGVLQPQDYNVVTQRMCTLGPDVFLHKCYRCPAEIVKTVSALVYENKFVPVNPESKQCFKMFVKGQVQIESNSSINHKQLEVVKAFLAHNPKWRKAVFISPYNSQNYVARRLLGLQTQTVDSAQGSEYDYVIYTQTSDTQHATNVNRFNVAITRAKVGILCIMCDRSMYDNLDFYELKDSKIGLQAKPETCGLFKDCSKNEQYIPPAYATTYMSLSDNFKTSDGLAVNIGTKDVKYANVISYMGFRFEANIPGYHTLFCTRDFAMRNVRAWLGFDVEGAHVCGDNVGTNVPLQLGFSNGVDFVVQTEGCVITEKGNSIEVVKARAPPGEQFAHLIPLMRKGQPWHIVRRRIVQMVCDYFDGLSDILIFVLWAGGLELTTMRYFVKIGKPQKCECGKTATCYSSSQCVYACFKHALGCDYLYTPYGIDIQQWGYTGSLSMNHHEVCNIHRNEHVASGDAIMTRCLAIHDCFVKRVDWSIVYPFIDNEEKINKAGRIVQSHVMKAALKIFNPAAIHDVGNPKGIRCATTPIPWFCYDRDPINNNVRCLEYDYMVHGQMNGLMLFWNCNVDMYPEFSIVCRFDTRTRSKLSLEGCNGGALYVNNHAFHTPAYDRRAFAKLKPMPFFYYDDSNCELVDGQPNYVPLKSNVCITKCNIGGAVCKKHAALYRAYVEDYNMFMQAGFTIWCPQNFDTYMLWHGFVNSKALQSLENVAFNVVKKGAFTGLKGDLPTAVIADKIMVREGPTDKCIFTNKTSLPTNVAFELYAKRKLGLTPPLTILRNLGVVATYKFVLWDYEAECPFSNFTKQVCSYTDLDSEVVTCFDNSIAGSFERFTTTKDAVLISNNAVKGLSAIKLQYGFLNDLPVSTVGNKPVTWYIYVRKNGEYVEQIDSYYTQGRTFETFKPRSTMEEDFLSMDTTLFIQKYGLEDYGFEHVVFGDVSKTTIGGMHLLISQVRLAKMGLFSVQEFMTNSDSTLKSCCITYADDPSSKNVCTYMDILLDDFVTIIKSLDLNVVSKVVDVIVDCKAWRWMLWCENSQIKTFYPQLQSAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNVVKYTQLCQYLNTTTLCVPHKMRVLHLGAAGASGVAPGSTVLRRWLPDDAILVDNDLRDYVSDADFSVTGDCTSLYIEDKFDLLISDLYDGSTKSIDGENTSKDGFFTYINGFIKEKLSLGGSAAIKITEFSWNKDLYELIQRFEYWTVFCTSVNTSSSEGFLIGINYLGPYCEKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVVGLLRKGKLLIRNNGKLLNFGNHLVNVP

Summary

Function
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
Non-structural protein 1 inhibits host translation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SAGC]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G).
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
Catalytic Activity
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
ATP + H2O = ADP + H(+) + phosphate
Subunit
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
3D-structure   Activation of host autophagy by virus   ATP-binding   Endonuclease   Exonuclease   Helicase   Host cytoplasm   Host membrane   Host-virus interaction   Hydrolase   Inhibition of host innate immune response by virus   Inhibition of host IRF3 by virus   Inhibition of host RLR pathway by virus   Membrane   Metal-binding   Methyltransferase   Modulation of host ubiquitin pathway by viral deubiquitinase   Modulation of host ubiquitin pathway by virus   Nuclease   Nucleotide-binding   Nucleotidyltransferase   Protease   Reference proteome   Repeat   Ribosomal frameshifting   RNA-binding   RNA-directed RNA polymerase   Thiol protease   Transferase   Transmembrane   Transmembrane helix   Ubl conjugation pathway   Viral immunoevasion   Viral RNA replication   Zinc   Zinc-finger  
Feature
chain  Non-structural protein 1
Uniprot
Pfam
PF01661   Macro
PF06471   NSP11
PF08717   nsp8
PF08716   nsp7
PF13087   AAA_12
PF16688   CNV-Replicase_N
PF08710   nsp9
PF09401   NSP10
PF08715   Viral_protease
PF05409   Peptidase_C30
PF06460   NSP16
PF16348   Corona_NSP4_C
PF06478   Corona_RPol_N
Interpro
IPR041679   DNA2/NAM7-like_AAA
IPR036499   NSP9_sf
IPR018995   RNA_synth_NSP10_coronavirus
IPR027351   (+)RNA_virus_helicase_core_dom
IPR029063   SAM-dependent_MTases
IPR038634   A-CoV_nsp1_sf
IPR042515   Nsp15_N
IPR038123   NSP4_C_sf
IPR037230   NSP8_sf
IPR027417   P-loop_NTPase
IPR002589   Macro_dom
IPR009461   Coronavirus_NSP16
IPR014827   Viral_protease
IPR013016   Peptidase_C30/C16
IPR014822   NSP9
IPR009003   Peptidase_S1_PA
IPR014829   NSP8
IPR037227   EndoU-like
IPR036333   NSP10_sf
IPR027352   CV_ZBD
IPR014828   NSP7
IPR032039   A-CoV_nsp1
IPR008740   Peptidase_C30
IPR037204   NSP7_sf
IPR009466   NSP11
IPR032505   Corona_NSP4_C
IPR009469   RNA_pol_N_coronovir
SUPFAM
SSF144246   SSF144246
SSF101816   SSF101816
SSF52540   SSF52540
SSF142877   SSF142877
SSF140367   SSF140367
SSF50494   SSF50494
SSF143076   SSF143076
SSF53335   SSF53335
ProteinModelPortal
PDB
6NUS     E-value=0.0     Score=1111     Identity=59.01%     Cov(Q)=13.87%     Cov(P)=97.07%

Ontologies

Subcellular Location

From MSLVP
Capsid
From Uniprot
Host membrane  
   nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).   With evidence from 3 publications.
Host endoplasmic reticulum-Golgi intermediate compartment   The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.   With evidence from 3 publications.

Topology

Length:
6684
Number of predicted TMHs:
16
Exp number of AAs in TMHs:
445.811029999996
Exp number, first 60 AAs:
0.0003
Total prob of N-in:
0.00045
outside
1  -  1888
TMhelix
1889  -  1911
inside
1912  -  1980
TMhelix
1981  -  2003
outside
2004  -  2017
TMhelix
2018  -  2040
inside
2041  -  2403
TMhelix
2404  -  2426
outside
2427  -  2495
TMhelix
2496  -  2518
inside
2519  -  2658
TMhelix
2659  -  2681
outside
2682  -  2690
TMhelix
2691  -  2713
inside
2714  -  2719
TMhelix
2720  -  2742
outside
2743  -  2745
TMhelix
2746  -  2768
inside
2769  -  3185
TMhelix
3186  -  3208
outside
3209  -  3212
TMhelix
3213  -  3235
inside
3236  -  3241
TMhelix
3242  -  3264
outside
3265  -  3283
TMhelix
3284  -  3306
inside
3307  -  3312
TMhelix
3313  -  3332
outside
3333  -  3363
TMhelix
3364  -  3386
inside
3387  -  3392
TMhelix
3393  -  3415
outside
3416  -  6684
 
 
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