Strain
Canine_JQ404410
(Region: USA; Strain: Canine coronavirus strain TN-449, complete genome.; Date: presumed 2012)
Gene
membrane
Description
Annotated in NCBI,
membrane
Location
GenBank Accession
Full name
Membrane protein
Alternative Name
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Sequence
CDS
ATGAAGCACTCCTCGTTTGAACTAAACAAAATGAAGATTTTGTTAATACTAGCGTGTGCAGTTGCATGCGTTTATGGGGAGCAAATAAGGTACTGTGCTATGCAAGAGACTGGTTTGTCATGTCGCAATGGTACAGCATCTGATTGTGAGTCATGCTTCAATGGAGGCGATCTTATTTGGCATCTTGCAAACTGGAACTTCAGCTGGTCTATAATATTGATCGTTTTTATAACGGTTCTACAATATGGTAGACCTCAATTTAGCTGGTTCGTGTATGGCATTAAAATGCTTATTATGTGGCTATTATGGCCCATTGTTTTGGCTCTTACGACTTTTAATGCATACTCGGAATATGAAGTGTCCAGATATGTAATGTTCGGCTTTAGTATTGCAGGTGCAATTATTACATTTGTACTTTGGATTATGTATTTTGTTAGATCCATTCAGTTATACAGAAGGACTAAGTCTTGGTGGTCTTTCAACCCTGAGACTAACGCAATTCTATGCGTTAGTGCATTAGGAAGAAGCTATGTGCTTCCTCTTGAAGGTGTGCCAACTGGCGTCACTCTAACATTGCTCTCAGGGAATTTGTACGCTGAAGGGTTCAAAATTGCTGGTGGTATGAACATCGACAATTTACCAAAATATGTAATGGTTGCATTACCTAGCAGGACCATTGTCTACACACTTGTTGGCAAGCAATTGAAAGCAAGTAGTGCAACAGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGATGCAAGAACTGACAATTTGAGTGAGCAAGAAAAATTATTACATATGGTATAA
Protein
MKHSSFELNKMKILLILACAVACVYGEQIRYCAMQETGLSCRNGTASDCESCFNGGDLIWHLANWNFSWSIILIVFITVLQYGRPQFSWFVYGIKMLIMWLLWPIVLALTTFNAYSEYEVSRYVMFGFSIAGAIITFVLWIMYFVRSIQLYRRTKSWWSFNPETNAILCVSALGRSYVLPLEGVPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKQLKASSATGWAYYVKSKAGDYSTDARTDNLSEQEKLLHMV
Summary
Function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Similarity
Belongs to the alphacoronaviruses M protein family.
Keywords
Glycoprotein
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Feature
chain Membrane protein
Uniprot
Pubmed
PRIDE
Pfam
PF01635
Corona_M
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Virion membrane
Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Topology
Length:
273
Number of predicted TMHs:
4
Exp number of AAs in TMHs:
87.61281
Exp number, first 60 AAs:
20.51277
Total prob of N-in:
0.96465
POSSIBLE N-term signal
sequence
inside
1 - 12
TMhelix
13 - 30
outside
31 - 57
TMhelix
58 - 80
inside
81 - 86
TMhelix
87 - 109
outside
110 - 123
TMhelix
124 - 146
inside
147 - 273
