Coronavirus Database

Strain

Bat_JQ989271 (Region: China; Strain: Rousettus bat coronavirus HKU10 isolate 175A, complete genome.; Date: 5-Oct)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

JQ989271(+):25611-26291

GenBank Accession

AFU92116.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

CDS

ATGTCTAATGAGACAATTCCTCTCGACCAGGTGGTCGAACATCTAAGAAATTGGAATTTCAGTTGGAATGTAATTCTTACAATATTTCTAGTTGTCCTTCAATATGGACACTACAAATATAGTGCTGTGCTTTACATCCTGAAAATGACAATTCTGTGGCTGTTGTGGCCTCTTGTACTTGCCCTGTCAATTTTTGACAGTTGGTCAAGTTTTGGCAACAACTGGACCATGTTTGCTTTTAGCATCTTAATGGCTTGCATTACGCTTGTGCTGTGGATAATGTACTTTGTCAACAGTTTCAGGCTGTACCGCAGAACCAACACTTTCTGGGCCTTTAACCCGGAAACTGATGCCATTATCACACTGTCCGTCTTTGGTCGCCAAGTTTCAATTCCAGCCCTTGTGGCTCCAACTGGCATTACGCTCACTGTGTTAAGTGGTACACTCCTAGTGGAAGGCATTAAGATTGCTACTGGTGTGCAGGTAAACCAATTACCTACGTACATCACTGTTGTTAAGCCTAGCACCACAATTGTGTATCAACGTGCTGGACGTTCGCTCAACACGCGCTCAAACACAGGTTGGGCGTTTTATGTCAGATCGAAAAATGGCGACTACTCTGCTGTAACGAGTTCTGCTGATTCGCTTACAGAAGACGAGAAACTTTTACATTTAGTCTAA

Protein

MSNETIPLDQVVEHLRNWNFSWNVILTIFLVVLQYGHYKYSAVLYILKMTILWLLWPLVLALSIFDSWSSFGNNWTMFAFSILMACITLVLWIMYFVNSFRLYRRTNTFWAFNPETDAIITLSVFGRQVSIPALVAPTGITLTVLSGTLLVEGIKIATGVQVNQLPTYITVVKPSTTIVYQRAGRSLNTRSNTGWAFYVRSKNGDYSAVTSSADSLTEDEKLLHLV

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

G8G0X8

Pubmed

22966198 23087112 23166239 23166262 22528639 22843324 + More
23685898 23969052 25125639 26112783 25694517 26063495 30380612

EMBL

JN083782 JN083783 JN083785 JN083787 JN089739 JN089740 + More
JN089741 JN089745 JN089746 JQ654496 JQ305133 JQ723736 JQ710438 JX002686 JX002691 JX188454 JX489155 JX524137 JX501325 JX647847 KF384500 KJ960178 KJ960179 KJ960180 KM609204 KM089829 KR610993 KR610994 KP765609 KX010481 KX010484 KX010488 KY698022 KY928065 MF346935 MG373542 MG373544 MF581000 MH708895 MG983755 MH061339 MH581489 MH748550 MH726384 MH726385 MH726386 MH726387 MH726388 MH726389 MH726390 MH726391 MH726392 MH726393 MH726402 MH726403 MH726404 MK690502 MK644603 MK644605 MK656470 MK656471 MK656476 MK656477 MK656478 MK656479 MK656480 MK656481 MK656482 MK656483 AER35134.1 AER35135.1 AER35137.1 AER35139.1 AER39420.1 AER39421.1 AER39422.1 AER39426.1 AER39427.1 AFD64565.1 AFF60690.1 AFJ54357.1 AFK73393.1 AFN66539.1 AFN66544.1 AFQ37601.1 AFV09317.1 AFV46347.1 AFV59247.1 AFW99001.1 AGR51645.1 AJP67405.1 AKE53208.1 AKH45341.1 AKO90058.1 AND65698.1 AND65701.1 AND65705.1 ARD24434.1 ART84253.1 ASO67380.1 AUD08949.1 AUD08951.1 AWU22295.1 AYL64495.1 AYW03312.1 AZL47213.1 AZP53860.1 AZS18881.1 QCQ19933.1 QCQ19939.1 QCQ19945.1 QCQ19951.1 QCQ19957.1 QCQ19963.1 QCQ19969.1 QCQ19975.1 QCQ19981.1 QCQ19987.1 QCQ20041.1 QCQ20047.1 QCQ20053.1 QER78626.1 QFG01703.1 QFG01715.1 QFG71733.1 QFG71734.1 QFG71739.1 QFG71740.1 QFG71741.1 QFG71742.1 QFG71743.1 QFG71744.1 QFG71745.1 QFG71746.1

Proteomes

UP000100611 UP000102013 UP000107040 UP000112802 UP000114638 UP000128510 + More
UP000133882 UP000137179 UP000150256 UP000150836 UP000150912 UP000157500 UP000172504

Pfam

PF01635 Corona_M

Interpro

IPR042551 ALPHA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

G8G0X8

GO

GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane
GO:0055036  C:virion membrane

From MSLVP

Host nucleus. Host cytoplasm.

Length:

226

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

76.5870700000001

Exp number, first 60 AAs:

36.7764

Total prob of N-in:

0.06199

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 38

inside

39 - 42

TMhelix

43 - 65

outside

66 - 74

TMhelix

75 - 97

inside

98 - 226

Sequence

Summary

Ontologies

Subcellular Location

Topology