Strain

Murine_JX169866 (Region: USA; Strain: Murine coronavirus strain JHM-WU-Dns2, complete genome.; Date: 14-Aug-47)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

JX169866(+):28379-29065

GenBank Accession

AFO11511.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAGTAGTACCACTCAGGCCCCAGGGCCCGTCTACCAATGGACAGCCGACGAGGCCGTTCAATTCCTTAAGGAATGGAACTTCTCGTTGGGCATTATACTACTCTTTATTACTATCATACTACAGTTCGGTTACACGAGCCGTAGCATGTTTATCTATGTTGTGAAAATGATAATCTTGTGGTTAATGTGGCCACTGATTATTGTTTTGTGTATGTTCAATTGCGTGTATGCGCTAAATAATGTGTATCTTGGATTTTCTATAGTGTTTACTATAGTGTCCGTTGTAATGTGGATTATGTATTTTGTTAATAGCATCAGGTTGTTTATCAGGACTGGTAGCTGGTGGAGCTTCAACCCCGAAACAAACAACCTAATGTGCATAGATATGAAAGGTACCGTGTATGTTAGACCCATTATTGAGGATTACCATACACTAACAGCCACTATTATTCGTGGCCACTTCTATATGCAAGGTGTTAAGCTAGGCACCGGTTTCTCTTTGTCTGACTTGCCTGCTTATGTTACAGTAGCTAAGGTTTCCCACCTTTGCACTTATAAGCGTGCATTCTTAGACAAGGTAGACGGTGTTAGCGGTTTTGCTGTTTATGTGAAGTCCAAGGTCGGAAATTACCGACTGCCCTCAAACAAACCGAGTGGCGCGGACACCGTATTGTTGAGAATCTAA

Protein

MSSTTQAPGPVYQWTADEAVQFLKEWNFSLGIILLFITIILQFGYTSRSMFIYVVKMIILWLMWPLIIVLCMFNCVYALNNVYLGFSIVFTIVSVVMWIMYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGTVYVRPIIEDYHTLTATIIRGHFYMQGVKLGTGFSLSDLPAYVTVAKVSHLCTYKRAFLDKVDGVSGFAVYVKSKVGNYRLPSNKPSGADTVLLRI

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

C6GHR5

EMBL

FJ938067 ACT11035.1

Proteomes

UP000164707

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

C6GHR5

Ontologies

GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

228

Number of predicted TMHs:

Exp number of AAs in TMHs:

64.61966

Exp number, first 60 AAs:

26.52565

Total prob of N-in:

0.49595

POSSIBLE N-term signal

sequence

outside

1 - 25

TMhelix

26 - 45

inside

46 - 57

TMhelix

58 - 80

outside

81 - 83

TMhelix

84 - 106

inside

107 - 228