Strain
Canine_JX860640
(Region: South Korea; Strain: Canine respiratory coronavirus strain K37, complete genome.; Date: 2008)
Gene
E protein
Description
Annotated in NCBI,
E protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTTATGGCTGATGCTTATTTTGCAGACACTGTGTGGTATGTGGGGCAAATAATTTTTATAGTTGCCATTTGTTCATTGGTTATAATAGTTGTAGTGGCATTTTTGGCAACTTTTAAATTGTGTATTCAACTTTGCGGTATGTGTAATACCTTAGTACTGTCCCCTTCTATTTATGTGTTTAATAGAGGTAGGCAGTTTTATGAGTTTTACAATGATGTAAAACCACCAGTTCTTGATGTGGATGACGTTTAG
Protein
MFMADAYFADTVWYVGQIIFIVAICSLVIIVVVAFLATFKLCIQLCGMCNTLVLSPSIYVFNRGRQFYEFYNDVKPPVLDVDDV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Keywords
Apoptosis
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Feature
chain Envelope small membrane protein
Uniprot
Pubmed
EMBL
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
KEGG
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
84
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
33.03569
Exp number, first 60 AAs:
32.37534
Total prob of N-in:
0.36326
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 84
