Strain

Avian_JX897900 (Region: China; Strain: UNVERIFIED: Infectious bronchitis virus isolate GX-NN09032, complete genome.; Date: 2009)

Gene

membrane glycoprotein

Description

Annotated in NCBI, membrane glycoprotein

Location

JX897900(+):24532-25212

GenBank Accession

AGC01546.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGGCGGATAATACCACCAATTGTACTCTTATTACTCAGCAAGCAACTGAGCTTTTTATAGAATATAATTTATTTGTAACCGCCTTCTTCTTGACTTTAACTATACTATTTCAGTATGGGTATGCAACTAGGAGTCGGATTATTTATATATTTAAGATGTTAGTGTTGTGGTGCTTTTGGCCCCTTAACATTGCAGTAGGTGTAATTTCATGTATATACCCACCGAACACAGCAGGTCTTGTTGCAGCGATAATTCTTACTGTGTTTGCGTGTCTATCTTTTGTTGGTTATTGGATTCAGAGCTTTAGACTCTTTAAACGGTGTAGGTCTTGGTGGTCGTTTAACCCTGAGAGCAATGCCGTAGGTTCAATACTCCTAACTAATGGTCAACAATGTAATTTTGCTATAGAGAGTGTGCCAATGGTGCTTTCTCCAATTATTAAGAATGGTGTTCTTTATTGTGAAGGTCAGTGGCTCGCTAAGTGTGAACCAGACCACTTGCCTAAAGATATTTTTGTTTGCACACCGGATAGACGTAATATCTATCGTATGGTGCAGAAATATACTGGTGACCAAAGCGGAAATAAGAAAAGGTTTGCTACATTTGTGTATGCGAAACAGTCAGTAGACACTGGCGAGCTAGAGAGTGTAGCAACAGGAGGAAGTAGTCTTTACACATAA

Protein

MADNTTNCTLITQQATELFIEYNLFVTAFFLTLTILFQYGYATRSRIIYIFKMLVLWCFWPLNIAVGVISCIYPPNTAGLVAAIILTVFACLSFVGYWIQSFRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLSPIIKNGVLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVATGGSSLYT

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A1P8VEW6

EMBL

KX302871 APZ73755.1

Pfam

PF01635 Corona_M

Interpro

IPR042550 GAMMA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

A0A1P8VEW6

Ontologies

GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

226

Number of predicted TMHs:

Exp number of AAs in TMHs:

66.1186900000001

Exp number, first 60 AAs:

32.80232

Total prob of N-in:

0.23240

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 42

inside

43 - 53

TMhelix

54 - 73

outside

74 - 76

TMhelix

77 - 99

inside

100 - 226