Strain

Canine_KC175339 (Region: Germany; Strain: Canine coronavirus strain 171, complete genome.; Date: 1971)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

KC175339(+):26188-26976

GenBank Accession

AFX81095.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAAGTACATTTTGCTAATACTCGCGTGCATAATTGCATGCGTTTATGGTGAACGCTACTGTGCCATGCAAGACAGTGGCTTGCAGTGTATTAATGGCACAAATTCAAGATGTCAAACCTGCTTTGAACGTGGTGATCTTATTTGGCATCTTGCTAACTGGAACTTCAGCTGGTCTGTAATATTGATTGTTTTTATAACAGTGTTACAATATGGCAGACCACAATTTAGCTGGCTCGTTTATGGCATTAAAATGCTGATCATGTGGCTATTATGGCCTATTGTTCTAGCGCTTACGATTTTTAATGCATACTCTGAGTACCAAGTTTCCAGATATGTAATGTTCGGCTTTAGTGTTGCAGGTGCAGTTGTAACGTTTGCACTTTGGATGATGTATTTTGTGAGATCTGTTCAGCTATATAGAAGAACCAAATCATGGTGGTCTTTTAATCCTGAGACTAATGCAATTCTTTGTGTTAATGCATTGGGTAGAAGTTATGTGCTTCCCTTAGATGGTACTCCTACAGGTGTTACCCTTACTCTACTTTCAGGAAATCTATATGCTGAAGGTTTCAAAATGGCTGGTGGTTTAACCATCGAGCATTTGCCTAAATACGTCATGATTGCTACACCTAGTAGAACCATCGTTTATACATTAGTTGGAAAACAATTAAAAGCAACTACTGCCACAGGATGGGCTTACTACGTAAAATCTAAAGCTGGTGATTACTCAACAGAAGCACGTACTGACAATTTGAGTGAACATGAAAAATTATTACATATGGTGTAA

Protein

MKYILLILACIIACVYGERYCAMQDSGLQCINGTNSRCQTCFERGDLIWHLANWNFSWSVILIVFITVLQYGRPQFSWLVYGIKMLIMWLLWPIVLALTIFNAYSEYQVSRYVMFGFSVAGAVVTFALWMMYFVRSVQLYRRTKSWWSFNPETNAILCVNALGRSYVLPLDGTPTGVTLTLLSGNLYAEGFKMAGGLTIEHLPKYVMIATPSRTIVYTLVGKQLKATTATGWAYYVKSKAGDYSTEARTDNLSEHEKLLHMV

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

C5IGL6

EMBL

FJ917533 ACR10409.1

Pfam

PF01635 Corona_M

Interpro

IPR042551 ALPHA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

C5IGL6

Ontologies

GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

262

Number of predicted TMHs:

Exp number of AAs in TMHs:

79.8215

Exp number, first 60 AAs:

24.00915

Total prob of N-in:

0.48790

POSSIBLE N-term signal

sequence

inside

1 - 46

TMhelix

47 - 69

outside

70 - 78

TMhelix

79 - 101

inside

102 - 111

TMhelix

112 - 134

outside

135 - 262