Strain
Canine_KC175340
(Region: USA: Ithaca, NY; Strain: Canine coronavirus strain K378, complete genome.; Date: 1978)
Gene
membrane protein
Description
Annotated in NCBI,
membrane protein
Location
GenBank Accession
Full name
Membrane protein
Alternative Name
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Sequence
CDS
ATGAAGATTTTGTTAATATTAGCGTGTGCAATTGCATGCGCATGTGGTGAACGTTATTGCGCCATGAAATCTGACTCAGAAACTTCGTGTCGTAATAGCACTGCTACTGATTGTGAATCATGCTTCAACGGAGGTGATCTTATTTGGCATCTTGCAAACTGGAACTTCAGCTGGTCTATAATATTGATCGTTTTTATAACGGTTTTACAATATGGTAGACCTCAATTTAGCTGGTTCGTGTATGGCATTAAAATGCTTATTATGTGGCTATTATGGCCCATTGTTTTGGCTCTTACGATTTTTAATGCATACTCTGAATATGAAGTTTCCAGATATGTAATGTTCGGCTTTAGTGTTGCAGGTGCAATTGTTACATTTATACTTTGGATTATGTATTTTATTAGATCCATTCAGTTATACAGAAGGACTAAGTCTTGGTGGTCTTTCAACCCTGAAACTAACGCAATTCTTTGCGTTAGTGCATTAGGAAGAAGCTACGTGCTTCCTCTTGAAGGTGTGCCAACTGGTGTCACTCTAACATTGCTCTCAGGGAATTTGTATGCTGAAGGGTTCAAAATTGCAGGTGGTATGAACATCGACAATTTACCAAAATACGTAATGGTTGCATTACCTAGCAGGACCATTGTCTACACACTTGTTGGCAAGAAATTGAAAGCAAGTAGTGCGACAGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGATGCACGAACTGATAATTTGAGTGAGCAAGAAAAATTATTACATATGGTATAA
Protein
MKILLILACAIACACGERYCAMKSDSETSCRNSTATDCESCFNGGDLIWHLANWNFSWSIILIVFITVLQYGRPQFSWFVYGIKMLIMWLLWPIVLALTIFNAYSEYEVSRYVMFGFSVAGAIVTFILWIMYFIRSIQLYRRTKSWWSFNPETNAILCVSALGRSYVLPLEGVPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKKLKASSATGWAYYVKSKAGDYSTDARTDNLSEQEKLLHMV
Summary
Function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Similarity
Belongs to the alphacoronaviruses M protein family.
Keywords
Glycoprotein
Host Golgi apparatus
Host membrane
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Feature
chain Membrane protein
Uniprot
Proteomes
PRIDE
Pfam
PF01635
Corona_M
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Virion membrane
Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Topology
Length:
262
Number of predicted TMHs:
3
Exp number of AAs in TMHs:
70.96498
Exp number, first 60 AAs:
13.83906
Total prob of N-in:
0.29364
POSSIBLE N-term signal
sequence
outside
1 - 46
TMhelix
47 - 69
inside
70 - 75
TMhelix
76 - 98
outside
99 - 112
TMhelix
113 - 135
inside
136 - 262
