Strain

Murine_KF268338 (Region: USA: Philadelphia; Strain: Murine coronavirus strain MHV/BHKR_lab/USA/icA59_L94P/2012, complete genome.; Date: 25-Oct-12)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

KF268338(+):28947-29633

GenBank Accession

AGT17742.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAGTAGTACTACTCAGGCCCCAGAGCCCGTCTATCAATGGACGGCCGACGAGGCAGTTCAATTCCTTAAGGAATGGAACTTCTCGTTGGGCATTATACTACTCTTTATTACTATCATACTACAGTTCGGTTACACGAGCCGTAGCATGTTTATTTATGTTGTGAAAATGATAATCTTGTGGTTAATGTGGCCACTGACTATTGTTTTGTGTATTTTCAATTGCGTGTATGCGCTAAATAATGTGTATCTTGGATTTTCTATAGTGTTTACTATAGTGTCCATTGTAATCTGGATTATGTATTTTGTTAATAGCATAAGGTTGTTTATCAGGACTGGTAGCTGGTGGAGCTTCAACCCCGAAACAAACAACCTTATGTGTATAGATATGAAAGGTACCGTGTATGTTAGACCCATTATTGAGGATTACCATACACTAACAGCCACTATTATTCGTGGCCACCTCTACATGCAAGGTGTTAAGCTAGGCACCGGTTTCTCTTTGTCTGACTTGCCCGCTTATGTTACAGTTGCTAAGGTGTCACACCTTTGCACTTATAAGCGCGCATTCTTAGACAAGGTAGACGGTGTTAGCGGTTTTGCTGTTTATGTGAAGTCCAAGGTCGGAAATTACCGACTGCCCTCAAACAAACCGAGTGGCGCGGACACCGCATTGTTGAGAACCTAA

Protein

MSSTTQAPEPVYQWTADEAVQFLKEWNFSLGIILLFITIILQFGYTSRSMFIYVVKMIILWLMWPLTIVLCIFNCVYALNNVYLGFSIVFTIVSIVIWIMYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGTVYVRPIIEDYHTLTATIIRGHLYMQGVKLGTGFSLSDLPAYVTVAKVSHLCTYKRAFLDKVDGVSGFAVYVKSKVGNYRLPSNKPSGADTALLRT

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

A7BKC7

Pubmed

17374765

EMBL

AB354579 BAF75636.1

Proteomes

UP000168103

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

A7BKC7

Ontologies

GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

228

Number of predicted TMHs:

Exp number of AAs in TMHs:

64.7462799999999

Exp number, first 60 AAs:

26.28326

Total prob of N-in:

0.55612

POSSIBLE N-term signal

sequence

inside

1 - 25

TMhelix

26 - 45

outside

46 - 49

TMhelix

50 - 72

inside

73 - 78

TMhelix

79 - 101

outside

102 - 228