Strain
Human_229E_KF514432
(Region: USA: Nashville, TN; Strain: Human coronavirus 229E strain 229E/human/USA/932-72/1993, complete genome.; Date: 22-Feb-93)
Gene
envelope small membrane protein
Description
Annotated in NCBI,
envelope small membrane protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTCCTTAAGCTAGTGGATGATCATGCTTTGATTGTTAATGTACTACTCTGGTGTGTGGTGCTTATAGTGATACTACTAGTGTGTATTACAATAATTAAACTAATTAAGCTTTGTTTCACTTGCCATATGTTTTGTAATAGAACAGTTTATGGCCCCATTAAAAATGTGTACCACATTTACCAATCATATATGCACATAGACCCTTTCCCTAAACGAGTTATTGATTTCTAA
Protein
MFLKLVDDHALIVNVLLWCVVLIVILLVCITIIKLIKLCFTCHMFCNRTVYGPIKNVYHIYQSYMHIDPFPKRVIDF
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Uniprot
Pubmed
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
77
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
23.38991
Exp number, first 60 AAs:
23.33183
Total prob of N-in:
0.10588
POSSIBLE N-term signal
sequence
outside
1 - 9
TMhelix
10 - 32
inside
33 - 77
