Strain
Feline_KF530123
(Region: Netherlands: Utrecht; Strain: Feline coronavirus strain Felis catus/NLD/UU88/2010, complete genome.; Date: 17-Aug-10)
Gene
envelope protein
Description
Annotated in NCBI,
envelope protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGATGTTTCCTAGGGCATTTACTATCATAGACGACCATGGTATGGTTGTTAGCGTTTTCTTCTGGCTCCTGTTGATAATTATATTGATATTGTTTTCAATAGCATTGCTAAATGTTATTAAGTTATGCATGGTATGTTGCAATTTGGGTAAGACTATTATAGTACTACCTGCACGCCATGCATATGATGCCTATAAGACTTTTATGCAAATTAAGGCATATAATCCCGACGAAGCATCTTTGGTTTGA
Protein
MMFPRAFTIIDDHGMVVSVFFWLLLIIILILFSIALLNVIKLCMVCCNLGKTIIVLPARHAYDAYKTFMQIKAYNPDEASLV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Keywords
Apoptosis
Host Golgi apparatus
Host membrane
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Feature
chain Envelope small membrane protein
Uniprot
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
82
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
23.91671
Exp number, first 60 AAs:
23.85528
Total prob of N-in:
0.06544
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 82
