Strain

Avian_KF636752 (Region: China; Strain: Bat Hp-betacoronavirus Zhejiang2013; Date: 2013/4/29)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

KF636752(+):28610-29281

GenBank Accession

AIL94219.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCGGGCGATAGCAACAACACCATTACCCAGGAGGAACTTTTTAAAGTTGTCAAGGAATGGAATTTCGCTTTAGGCATTATGCTTTTTATATTCATCACACTTCTGCAGTATGCTTACGCTACTCGCAGTCTGGGACTGTATATACTAAAGCTTGTGCTTCTTTGGCTCATGTGGCCACTCACTTTTGCATGCTTTGTGCTTGCTGCCATTTACCACGTGAACGTTGTGTTCATGGGATTTGCCATCACATTTGCTATTATTGTTGGGTGCATGTGGCTTGGTTACTGGATTGCCTCAATCCGTCTGTTCAGAAGAACTGGTTCTGTTTGGTCTTTCAATCCAGAAACCAACAGACTGCTGAACGTAGCGATTCGTGGAACCATGTACACCAGACCACTGCAGGAAGACACTGCTGTGATTGTAGCTACAGTTGCTCGTGGAGTAGCTGTATTTGCAGGACACAAACTTGGAAGAGCTGACCTTGAGTCATTGCCTAACGAAATTACTGTAGCCACCTCCAGAACGCTTTCCTATTTTAAGATGAGTAGGAAAGTAAATATTGGTGTTGGCTCGGGTGTTGCGACCTATTTGCGTTACAAAGTGGGAAACCACCGAGTGCCAAATGCTCGCGCATCTGAAGATCAAGAAGATCTGCTAGTTGTATCGTAA

Protein

MSGDSNNTITQEELFKVVKEWNFALGIMLFIFITLLQYAYATRSLGLYILKLVLLWLMWPLTFACFVLAAIYHVNVVFMGFAITFAIIVGCMWLGYWIASIRLFRRTGSVWSFNPETNRLLNVAIRGTMYTRPLQEDTAVIVATVARGVAVFAGHKLGRADLESLPNEITVATSRTLSYFKMSRKVNIGVGSGVATYLRYKVGNHRVPNARASEDQEDLLVVS

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

A0A2D1PXB3

Pubmed

29190287

EMBL

KY417150 ATO98209.1

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

A0A2D1PXB3

Ontologies

GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0019031  C:viral envelope
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Topology

Length:

223

Number of predicted TMHs:

Exp number of AAs in TMHs:

65.60461

Exp number, first 60 AAs:

30.97781

Total prob of N-in:

0.58846

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 42

inside

43 - 48

TMhelix

49 - 71

outside

72 - 75

TMhelix

76 - 98

inside

99 - 223