Strain
Avian_KJ425489
(Region: China; Strain: Infectious bronchitis virus strain ck/CH/LHB/111172, complete genome.; Date: 18-Nov-11)
Gene
E protein
Description
Annotated in NCBI,
E protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGATGAATGTACTGAATAAGTCGCTACAGGAGAACGGAAGTTTTCTAACAGCACTTTATGTATTTGTGGGCTTTATAGCACTCTATCTATTAGGAAGAGCGCTACAAGCATTTGTACAAGCAGCTGATGCTTGTTGCTTATTCTGGTACACATGGGTAGTAGTTCCTGGATCTAAGGGCACAGCCTTTGTGTACAAGCATACATATGGTAAAAAACTTAACAATCCGGAATTAGAAGCGGTTATTGTTAACGAGTTCCCAAAGAACGGTTGGAATAATAAAAATCCATCAAATTTTCAAGATGTCCAATGTGACAAATTGCACACTTGA
Protein
MMNVLNKSLQENGSFLTALYVFVGFIALYLLGRALQAFVQAADACCLFWYTWVVVPGSKGTAFVYKHTYGKKLNNPELEAVIVNEFPKNGWNNKNPSNFQDVQCDKLHT
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.
Similarity
Belongs to the gammacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF03620
IBV_3C
Interpro
IPR005296
IBV_3C
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
109
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
34.69603
Exp number, first 60 AAs:
32.05747
Total prob of N-in:
0.58937
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 32
inside
33 - 109
