Strain

Avian_KJ425500 (Region: China; Strain: Infectious bronchitis virus strain ck/CH/LHB/131132, complete genome.; Date: 21-Nov-13)

Gene

M protein

Description

Annotated in NCBI, M protein

Location

KJ425500(+):24451-25128

GenBank Accession

AHX26032.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCCAACGAAACAAATTGTACTCTTGACTTTGAACAGTCAGTTGAGCTTTTTAAAGAGTATAATTTATTTATAACTGCATTCTTGTTGTTCTTAACCATAATACTTCAGTATGGTTATGCAACAAGAAGTAAGTTTATTTATATACTTAAAATGATAGTGTTATGGTGCTTTTGGCCCCTTAACATTGCAGTAGGTGTAATTTCATGTATATACCCACCAAACACAGGAGGTCTTGTCGCAGCGATAATACTTACTGTGTTTGCGTGTCTTTCTTTTGTAGGTTATTGGATCCAGAGTATTAGACTCTTTAAGCGGTGTAGATCTTGGTGGTCATTTAACCCAGAATCTAACGCCGTAGGTTCAATACTCCTAACTAATGGTCAACAATGTAATTTTGCTATAGAGAGTGTGCCGATGGTGCTTTCTCCTATTATAAAGAATGGTGTTCTTTATTGTGAGGGTCAGTGGCTTGCTAAATGTGAACCAGACCACTTGCCTAAAGACATATTTGTATGCACACCAGATAGACGTAATATCTATCGTATGGTGCAGAAATACATTGGTGACCAAAGCGGAAATAAGAAAAGGTTTGCTACATTTGTCTATGCAAAGCAGTCAGTAGACACTGGCGAGCTAGAAAGTGTAGCAACAGGTGGAAGTAGCCTTTACACATAA

Protein

MSNETNCTLDFEQSVELFKEYNLFITAFLLFLTIILQYGYATRSKFIYILKMIVLWCFWPLNIAVGVISCIYPPNTGGLVAAIILTVFACLSFVGYWIQSIRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLSPIIKNGVLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYIGDQSGNKKRFATFVYAKQSVDTGELESVATGGSSLYT

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A1P8SMV9

EMBL

KX252785 APY23600.1

Pfam

PF01635 Corona_M

Interpro

IPR042550 GAMMA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

A0A1P8SMV9

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

225

Number of predicted TMHs:

Exp number of AAs in TMHs:

63.83474

Exp number, first 60 AAs:

31.87407

Total prob of N-in:

0.16068

POSSIBLE N-term signal

sequence

outside

1 - 22

TMhelix

23 - 40

inside

41 - 46

TMhelix

47 - 69

outside

70 - 78

TMhelix

79 - 98

inside

99 - 225