Strain
Bat_KJ473799
(Region: China; Strain: Miniopterus bat coronavirus HKU8; Date: 2012)
Gene
small envelope protein
Description
Annotated in NCBI,
small envelope protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTAACATTGATTGATGACCACGGGTTGGTTGTCAACATTTTACTTTGGTTAATAGTGTGTATATGCGTCATCATTATTTGCAGTTCTATTATTCAGTTTGTGCAGCTGTTGTTTTCTTGTCACAGACTGTGCTCTAATACTGTTTATAGGCCTGTTTATGGTGCATATCGCGCTTACCAAGATTATATGCGAATAGATCCACTCCCAGTTATTGATGTCTAA
Protein
MLTLIDDHGLVVNILLWLIVCICVIIICSSIIQFVQLLFSCHRLCSNTVYRPVYGAYRAYQDYMRIDPLPVIDV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Ontologies
Subcellular Location
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
23.16429
Exp number, first 60 AAs:
23.16371
Total prob of N-in:
0.47837
POSSIBLE N-term signal
sequence