Strain

Bat_KJ473820 (Region: China; Strain: Pipistrellus bat coronavirus HKU5; Date: 2013)

Gene

membrane glycoprotein

Description

Annotated in NCBI, membrane glycoprotein

Location

KJ473820(+):28169-28831

GenBank Accession

AIA62349.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGGCGTCTAGCAATGTTACCCTCACTAACGATGAGGTTCTCAGGCTTGTTAAAGACTGGAATTTCACCTGGTCGGTGGTTTTCCTGCTCATTACAATCGTGCTCCAATATGGCTACCCATCTAGGAGCATGTTTGTCTACGTCATTAAGATGTTTGTATTATGGCTACTTTGGCCAGCATCAATGGCACTATCTATATTTTGTGCTGTCTATCCAATTGATTTAGCTTCCCAGATAATTTCTGGCATACTAGCCGCAACAAGCTGCGCGATGTGGATTTCATACTTCGTGCAAAGCATTCGGCTGTTTATGCGTACTGGCTCCTGGTGGTCTTTCAACCCAGAGTCTAACTGTCTACTTAATGTTCCCATCGGAGGCACCACTGTTGTCCGACCACTTGTTGAAGATTCAACCAGTGTCACTGCTGTGGTTACCGATGGCTACCTTAAGATGGCAGGCATGCATTTCGGTGCTTGCGACTTTCAACGTCTACCCTCTGAGGTGACGGTCGCAAAACCAAATGTGCTGATAGCCCTGAAAATGATCAAACGCCAAGCGTATGGTACAAATTCTGGTGTTGCTATTTATCATAGGTATAAGGCAGGCAACTATAGAAGGCCGCCCATTATACAAGACCAAGAACTCGCACTGCTAAGGGCTTAA

Protein

MASSNVTLTNDEVLRLVKDWNFTWSVVFLLITIVLQYGYPSRSMFVYVIKMFVLWLLWPASMALSIFCAVYPIDLASQIISGILAATSCAMWISYFVQSIRLFMRTGSWWSFNPESNCLLNVPIGGTTVVRPLVEDSTSVTAVVTDGYLKMAGMHFGACDFQRLPSEVTVAKPNVLIALKMIKRQAYGTNSGVAIYHRYKAGNYRRPPIIQDQELALLRA

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

C6GHQ3

EMBL

FJ938066 ACT11023.1

Proteomes

UP000162935

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

C6GHQ3

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

Topology

Length:

220

Number of predicted TMHs:

Exp number of AAs in TMHs:

62.74646

Exp number, first 60 AAs:

30.05218

Total prob of N-in:

0.06607

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 39

inside

40 - 50

TMhelix

51 - 73

outside

74 - 77

TMhelix

78 - 97

inside

98 - 220