Strain
Camel_KT253328
(Region: Saudi Arabia; Strain: Camel alphacoronavirus Camel229E isolate Camel229E-CoV/JC50_HUH7/KSA/2014, complete genome.; Date: 2014)
Gene
E
Description
Annotated in NCBI,
E
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTTCTGAAGCTAGTGGATGATCATGCTTTAGTTGTAAATGTAATACTGTGGTGCGTAGTACTTATAGTACTTTTGCTAGTTTGTATTACAATTATTAAACTAATTAAATTATGTTTTACATGCCATATGTTTTGTAATAAAACGATTTATGGTCCCATTAAAAATGTGTATCACATTTACCAATCATACATGCACATAGACCCTTTCCCTAGACAAATTATTGATGTCTAA
Protein
MFLKLVDDHALVVNVILWCVVLIVLLLVCITIIKLIKLCFTCHMFCNKTIYGPIKNVYHIYQSYMHIDPFPRQIIDV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Uniprot
EMBL
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
77
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
23.18165
Exp number, first 60 AAs:
23.158
Total prob of N-in:
0.09161
POSSIBLE N-term signal
sequence
outside
1 - 9
TMhelix
10 - 32
inside
33 - 77
