Strain

Human_NL63_KT381875 (Region: USA; Strain: Human coronavirus NL63 isolate NL63/UF-1/2015, complete genome.; Date: 2015)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

KT381875(+):25442-26122

GenBank Accession

ALJ53434.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCTAATAGTAGTGTGCCTCTTTCAGAGGTTTATGTCCATTTACGTAACTGGAACTTTAGTTGGAATTTAATTCTAACAGTTTTTATAGTTGTGTTGCAGTATGGGCATTATAAGTATAGCAGACTTCTTTATGGTTTAAAGATGTCTGTTTTATGGTGTTTATGGCCACTTGTTCTAGCTTTGTCTATTTTTGACTGTTTTGTCAATTTTAATGTGGACTGGGTCTTTTTTGGTTTTAGTATTCTTATGTCTATTATTACACTTTGTTTATGGGTTATGTATTTTGTTAATAGTTTCAGACTTTGGCGCCGTGTTAAAACTTTTTGGGCTTTTAATCCTGAAACTAATGCAATCATCTCTCTCCAGGTTTACGGACATAATTATTACTTACCGGTGATGGCTGCACCTACAGGTGTTACATTAACACTTCTCAGTGGTGTACTTCTTGTTGATGGCCATAAGATTGCTACTCGTGTTCAAGTGGGTCAGTTGCCTAAATATGTAATAGTTGCTACACCTAGTACCACAATTGTTTGTGACCGTGTTGGTCGCTCTGTTAATGAAACAAGCCAGACTGGTTGGGCATTCTACGTCCGTGCTAAACATGGTGATTTTTCTGGTGTTGCCTCTCAGGAGGGTGTTTTGTCAGAAAGAGAGAAGTTGCTTCATTTAATCTAA

Protein

MSNSSVPLSEVYVHLRNWNFSWNLILTVFIVVLQYGHYKYSRLLYGLKMSVLWCLWPLVLALSIFDCFVNFNVDWVFFGFSILMSIITLCLWVMYFVNSFRLWRRVKTFWAFNPETNAIISLQVYGHNYYLPVMAAPTGVTLTLLSGVLLVDGHKIATRVQVGQLPKYVIVATPSTTIVCDRVGRSVNETSQTGWAFYVRAKHGDFSGVASQEGVLSEREKLLHLI

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

K9YG98

EMBL

JX869046 AFZ45986.1

Pfam

PF01635 Corona_M

Interpro

IPR042551 ALPHA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

K9YG98

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0055036  C:virion membrane
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane
Virion membrane

Topology

Length:

226

Number of predicted TMHs:

Exp number of AAs in TMHs:

87.06807

Exp number, first 60 AAs:

35.61638

Total prob of N-in:

0.12806

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 38

inside

39 - 42

TMhelix

43 - 65

outside

66 - 74

TMhelix

75 - 97

inside

98 - 128

TMhelix

129 - 151

outside

152 - 226