Strain

Feline_KU215420 (Region: Belgium; Strain: Feline coronavirus isolate Cat1_day7, complete genome.; Date: 2013)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

KU215420(+):26123-26911

GenBank Accession

AMD11147.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAAGTACGTTTTGCTCATGTTCGCGTGCATAATTGCATGCGTTTGTGGTGAACGATACTGTGCCATGCAAGGTGCAAGTACAAGCTGCATCAATGGCACCAATTCAGAATGTCAAACCTGCTTTGAACGTGGTGATCTTATTTGGCATCTTGCTAACTGGAACTTCAGCTGGTCCGTAATATTGATCGTTTTTATAACAGTTTTACAATATGGAAGACCGCAATTTAGCTGGCTCGTTTATGGCATTAAAATGCTGATCATGTGGCTATTATGGCCTATTGTTCTAGCGCTTACGATTTTTAATGCATACTCCGAGTACCAAGTTTCCAGATATGTAATGTTCGGCTTTAGTGTTGCAGGTGCAGTCATAACGTTTGCACTCTGGATGATGTATTTTGTGAGATCCATTCAGCTATATAGAAGGACCAAATCATGGTGGTCTTTCAACCCTGAAACTAATGCAATTCTTTGTGTTAACGCACTGGGTAGAAGTTATGTTTTACCCCTTGATGGCACTCCTACAGGTGTCACTCTTACTTTGCTTTCAGGAAATCTATATGCTGAAGGTTTTAAGATGGCTGGTGGTCTTACCATCGAGCAATTGCCTAAATACGTCATGATTGCTACACCTAGTAGAACCATCGTTTACACATTAGTTGGGAAACAATTAAAAGCAACTACTGCTACAGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGAAGCACGTACTGATAATTTGAGTGAACATGAAAAATTATTACATATGGTGTAA

Protein

MKYVLLMFACIIACVCGERYCAMQGASTSCINGTNSECQTCFERGDLIWHLANWNFSWSVILIVFITVLQYGRPQFSWLVYGIKMLIMWLLWPIVLALTIFNAYSEYQVSRYVMFGFSVAGAVITFALWMMYFVRSIQLYRRTKSWWSFNPETNAILCVNALGRSYVLPLDGTPTGVTLTLLSGNLYAEGFKMAGGLTIEQLPKYVMIATPSRTIVYTLVGKQLKATTATGWAYYVKSKAGDYSTEARTDNLSEHEKLLHMV

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

C5IGL6

EMBL

FJ917533 ACR10409.1

Pfam

PF01635 Corona_M

Interpro

IPR042551 ALPHA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

C5IGL6

Ontologies

GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

262

Number of predicted TMHs:

Exp number of AAs in TMHs:

74.78936

Exp number, first 60 AAs:

18.93027

Total prob of N-in:

0.50923

POSSIBLE N-term signal

sequence

inside

1 - 48

TMhelix

49 - 71

outside

72 - 85

TMhelix

86 - 105

inside

106 - 111

TMhelix

112 - 134

outside

135 - 262