Strain

Camel_KU291449 (Region: Kenya; Strain: Camel alphacoronavirus Camel229E isolate Camel229E-CoV/KCSP1/KEN/2015, complete genome.; Date: 2015)

Gene

Description

Annotated in NCBI, M

Location

KU291449(+):24847-25527

GenBank Accession

AOG74792.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGACTGAAGCTAATATTACTCAGGAGGAGTTGGTAACTCACCTGAAAAATTGGAATTTTAGTTGGAATATTATTCTAACTATTTTCATTGTCATTCTTCAGTTTGGCCATTATAAATACTCAAGAATCTTTTATGGTCTGAAGATGCTAGTTTTGTGGCTTTTGTGGCCACTTGTACTTGCACTTTCAATCTTTGACACTTGGGCAAACTGGGGATCCAACTGGGCCTTTGTCGCATTCAGCCTTTTTATGGCCGTATCAACACTCATTATGTGGGTGATGTATTTCGTAAATAGTTTCAGACTTTTCCGACGTGCTCGAACTTTTTGGGCATGGAACCCGGAAGTGAATGCAATCACAGTCACAACCGTGCTGGGACAGACGTACTACCAACCCATTCAACAAGCTCCAACAGGCATTACGGTGACTTTGCTGAGCGGTGTGCTTTACGTGGACGGACATAGATTGGCTTCAGGTGTTCAGGTTCATAACCTACCTGAATACATGACAGTTGCCGTGCCGAGCACTACTATAATTTATAGTAGAGTCGGAAGGTCCGTAAATTCACGAAACAGCACAGGCTGGGTTTTCTACGTACGAGTAAAACACGGTGACTTTTCTGCAGTGAGCTCTCCTACGAGCAATATGACAGAAAACGAAAGATTGCTTCATTTGATCTAA

Protein

MTEANITQEELVTHLKNWNFSWNIILTIFIVILQFGHYKYSRIFYGLKMLVLWLLWPLVLALSIFDTWANWGSNWAFVAFSLFMAVSTLIMWVMYFVNSFRLFRRARTFWAWNPEVNAITVTTVLGQTYYQPIQQAPTGITVTLLSGVLYVDGHRLASGVQVHNLPEYMTVAVPSTTIIYSRVGRSVNSRNSTGWVFYVRVKHGDFSAVSSPTSNMTENERLLHLI

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

G9HVU3

Pubmed

23269482

EMBL

JN400902 AEW24880.1

Pfam

PF01635 Corona_M

Interpro

IPR042551 ALPHA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

G9HVU3

Ontologies

GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

226

Number of predicted TMHs:

Exp number of AAs in TMHs:

66.3825599999999

Exp number, first 60 AAs:

35.33224

Total prob of N-in:

0.11563

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 38

inside

39 - 42

TMhelix

43 - 65

outside

66 - 74

TMhelix

75 - 97

inside

98 - 226