Strain
Bat_KX442565
(Region: China; Strain: Hypsugo bat coronavirus HKU25 isolate NL140462, complete genome.; Date: 8-May-14)
Gene
envelope protein
Description
Annotated in NCBI,
envelope protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTACCCTTTGTCCAAGAACAAATAGGGTCATTCATAGTAAACTTTTTCATCTTCACCGTAGCTTGTGCTATTACACTTTTAGTTTGTATGGCATTCCTTACGGCCACGCGATTATGTATGCAGTGTGCAATAGGTGTTAATACCCTATTAGTACAACCTGCCATATATGTATATATCACAGGACGTTCTGCCTATGTTAAGTTTCAAGAGAGTAAACCTCCTCTACCCCCTGATGAGTGGGTTTAA
Protein
MLPFVQEQIGSFIVNFFIFTVACAITLLVCMAFLTATRLCMQCAIGVNTLLVQPAIYVYITGRSAYVKFQESKPPLPPDEWV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Uniprot
EMBL
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
PDB
5X29
E-value=2e-06 Score=41.6 Identity=43.10%
Cov(Q)=70.73% Cov(P)=71.60%
3D Structure
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
82
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
40.88074
Exp number, first 60 AAs:
38.25594
Total prob of N-in:
0.55129
POSSIBLE N-term signal
sequence
inside
1 - 11
TMhelix
12 - 34
outside
35 - 37
TMhelix
38 - 60
inside
61 - 82
