Strain
Human_TGEV_KX900393
(Region: USA; Strain: Transmissible gastroenteritis virus strain TGEV/USA/Z/1986, complete genome.; Date: 8-Dec-06)
Gene
envelope protein
Description
Annotated in NCBI,
envelope protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGACGTTTCCTAGGGCATTGACTGTCATAGATGACAATGGAATGGTCATTAACATCATTTTCTGGTTCCTGTTGATAATTATATTGATATTACTTTCAATAGCATTGCTAAATATAATTAAGCTATGCATGGTGTGTTGCAATTTAGGAAGGACAGTTATTATTGTTCCAGCGCAACATGCTTACGATGCTTATAAGAATTTTATGCGAATTAAAGCATACAACCCCGATGGAGCACTCCTTGCTTGA
Protein
MTFPRALTVIDDNGMVINIIFWFLLIIILILLSIALLNIIKLCMVCCNLGRTVIIVPAQHAYDAYKNFMRIKAYNPDGALLA
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
82
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
23.98981
Exp number, first 60 AAs:
23.90336
Total prob of N-in:
0.04933
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 82
