Strain

Human_TGEV_KX900400 (Region: USA: Iowa; Strain: Transmissible gastroenteritis virus strain TGEV/USA/Iowa143/2008, complete genome.; Date: 6-Mar-08)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

KX900400(+):26058-26843

GenBank Accession

ASV64343.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAAGATTTTGTTGATATTGGCGTGTGCGATTGCATGCGCATGTGGAGAACGCTATTGTGCTATGCAAGACACAGGTTTGTCATGTCGCAATAGCACAGTGTCTGATTGTGAGTCATGCTTCAACGGGGGCGATCTTATTTGGCATCTTGCAAACTGGAACTTCAGCTGGTCTATAATATTGATCATTTTTATTACTGTGCTACAATATGGAAGACCTCAATTCAGCTGGTTCGTGTATGGCATTAAAATGCTTATAATGTGGCTATTATGGCCCATTGTTTTGGCTCTTACGATTTTTAATGCATACTCGGAATACCAAGTTTCCAGGTATGTAATGTTCGGCTTTAGTATTGCAGGTGCAATTGTTACATTTGTACTCTGGATTATGTATTTTGTAAGATCCATTCAGCTATACAGAAGGACTAAGTCCTGGTGGTCCTTCAACCCTGAAACTAATGCAATTCTTTGCGTTAGTGCACTAGGAAGAAGCTATGTGCTCCCTCTCGAGGGTGTGCCAACTGGTGTCACTCTAACTCTGCTTTCAGGGAATTTATACGCTGAAGGGTTCAAAATTGCTGGTGGTATGAACATCGACAATTTGCCAAAATATGTAATGGTTGCATTACCCAGCAGGACTATAGTCTACACACTTGTTGGCAAGAAGTTGAAAGCAAGTAGTGCGACTGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGAGGCAAGAACTGATAATTTGAGTGAGCAAGAAAAATTATTACATATGGTATAA

Protein

MKILLILACAIACACGERYCAMQDTGLSCRNSTVSDCESCFNGGDLIWHLANWNFSWSIILIIFITVLQYGRPQFSWFVYGIKMLIMWLLWPIVLALTIFNAYSEYQVSRYVMFGFSIAGAIVTFVLWIMYFVRSIQLYRRTKSWWSFNPETNAILCVSALGRSYVLPLEGVPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKKLKASSATGWAYYVKSKAGDYSTEARTDNLSEQEKLLHMV

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Keywords

Glycoprotein Host Golgi apparatus Host membrane Membrane Reference proteome Transmembrane Transmembrane helix Viral envelope protein Viral matrix protein Virion

Feature

chain Membrane protein

Uniprot

P04135

Pubmed

2841792 3035066 2825819 10805807 3008432 11152504 + More
1309909 7636969

EMBL

M21627 X05598 X06371 AJ271965 M14878

Proteomes

UP000001440

PRIDE

P04135

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M
IPR042551 ALPHA_CORONA_M

ProteinModelPortal

P04135

Ontologies

GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0030430  C:host cell cytoplasm
GO:0055036  C:virion membrane
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Virion membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.

Topology

Length:

261

Number of predicted TMHs:

Exp number of AAs in TMHs:

71.37607

Exp number, first 60 AAs:

15.25298

Total prob of N-in:

0.34494

POSSIBLE N-term signal

sequence

outside

1 - 45

TMhelix

46 - 68

inside

69 - 74

TMhelix

75 - 97

outside

98 - 111

TMhelix

112 - 134

inside

135 - 261