Strain

Human_TGEV_KX900403 (Region: USA: Illinois; Strain: Transmissible gastroenteritis virus strain TGEV/USA/Illinois146/2008, complete genome.; Date: 9-Apr-08)

Gene

envelope protein

Description

Annotated in NCBI, envelope protein

Location

KX900403(+):25799-26047

GenBank Accession

ASV64370.1

Full name

Envelope small membrane protein

Sequence

CDS

ATGACGTTTCCTAGGGCATTGACTGTCATAGATGACAATGGAATGGTCATTAGCATCATTTTCTGGTTCCTGTTGATAATTATATTGATATTACTTTCAATAGCATTGCTAAATATAATTAAGCTATGTATGGTGTGTTGCAATTTAGGAAGAACAGTTATTATTGTTCCAGTGCAACATGCTTACGATGCCTATAAGAATTTTATGCGAATTAAAGCATATAACCCCGATGGAGCACTCCTTGTTTGA

Protein

MTFPRALTVIDDNGMVISIIFWFLLIIILILLSIALLNIIKLCMVCCNLGRTVIIVPVQHAYDAYKNFMRIKAYNPDGALLV

Summary

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Similarity

Belongs to the alphacoronaviruses E protein family.

Uniprot

A0A088NC56

EMBL

KJ879377 AIN55853.1

Pfam

PF02723 NS3_envE

Interpro

IPR003873 NS3/E

ProteinModelPortal

A0A088NC56

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0046760  P:viral budding from Golgi membrane
GO:0044662  P:disruption by virus of host cell membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.

Topology

Length:

Number of predicted TMHs:

Exp number of AAs in TMHs:

24.71724

Exp number, first 60 AAs:

24.57287

Total prob of N-in:

0.03338

POSSIBLE N-term signal

sequence

outside

1 - 14

TMhelix

15 - 37

inside

38 - 82