Strain
Canine_KY063617
(Region: China; Strain: Canine coronavirus isolate HLJ-072, complete genome.; Date: 1-Jul-16)
Gene
M
Description
Annotated in NCBI,
M
Location
GenBank Accession
Full name
Membrane protein
Alternative Name
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Sequence
CDS
ATGAAGCACTCCTCGTTTGAACTAAACAAAATGAAGATTTTGTTAATACTAGCGTGTGCAGTTGCATGCGTTTATGGGGAGCAAATAAGGTACTGTGCTATGCAAGAGACTGGTTTGTCATGTCGCAATGGTACAGCATCTGATTGTGAGTCATGCTTCAATGGAGGCGATCTTATTTGGCATCTTGCAAACTGGAACTTCAGCTGGTCTATAATATTGATCGTTTTTATAACGGTTCTACAATATGGTAGACCTCAATTTAGCTGGTTCGTGTATGGCATTAAAATGCTTATTATGTGGCTATTATGGCCCATTGTTTTGGCTCTTACGACTTTTAATGCATACTCGGAATATGAAGTGTCCAGATATGTAATGTTCGGCTTTAGTATTGCAGGTGCAATTATTACATTTGTACTTTGGATTATGTATTTTGTTAGATCCATTCAGTTATACAGAAGGACTAAGTCTTGGTGGTCTTTCAACCCTGAGACTAACGCAATTCTATGCGTTAGTGCATTAGGAAGAAGCTATGTGCTTCCTCTTGAAGGTGTGCCAACTGGCGTCACTCTAACATTGCTCTCAGGGAATTTGTACGCTGAAGGGTTCAAAATTGCTGGTGGTATGAACATCGACAATTTACCAAAATATGTAATGGTTGCATTACCTAGCAGGACCATTGTCTACACACTTGTTGGCAAGCAATTGAAAGCAAGTAGTGCAACAGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGATGCAAGAACTGACAATTTGAGTGAGCAAGAAAAATTATTACATATGGTATAA
Protein
MKHSSFELNKMKILLILACAVACVYGEQIRYCAMQETGLSCRNGTASDCESCFNGGDLIWHLANWNFSWSIILIVFITVLQYGRPQFSWFVYGIKMLIMWLLWPIVLALTTFNAYSEYEVSRYVMFGFSIAGAIITFVLWIMYFVRSIQLYRRTKSWWSFNPETNAILCVSALGRSYVLPLEGVPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKQLKASSATGWAYYVKSKAGDYSTDARTDNLSEQEKLLHMV
Summary
Function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Similarity
Belongs to the alphacoronaviruses M protein family.
Keywords
Glycoprotein
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Feature
chain Membrane protein
Uniprot
Pubmed
PRIDE
Pfam
PF01635
Corona_M
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Virion membrane
Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Topology
Length:
273
Number of predicted TMHs:
4
Exp number of AAs in TMHs:
87.61281
Exp number, first 60 AAs:
20.51277
Total prob of N-in:
0.96465
POSSIBLE N-term signal
sequence
inside
1 - 12
TMhelix
13 - 30
outside
31 - 57
TMhelix
58 - 80
inside
81 - 86
TMhelix
87 - 109
outside
110 - 123
TMhelix
124 - 146
inside
147 - 273
