Strain
Canine_KY063618
(Region: China; Strain: Canine coronavirus isolate HLJ-073, complete genome.; Date: 1-Jul-16)
Gene
E
Description
Annotated in NCBI,
E
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGACGTTCCCCAGGGCATTGACTGTCATAGATGACTATGGAATGGTCATTAGTATCATTTTTTGGTTCCTGTTGATAATCATATTGACATTACTTTCAATAGCATTGCTAAATATAATTAAGCTATGCATGGTGTGTTGCAATTTAGGGAGAACAGTTATTATTGTCCCAGCGCAACATGCTTACGATGCCTATAAGAATTTTATGCGAATTAAAGCATACAACCCCGATGAAGCACTCCTCGTTTGA
Protein
MTFPRALTVIDDYGMVISIIFWFLLIIILTLLSIALLNIIKLCMVCCNLGRTVIIVPAQHAYDAYKNFMRIKAYNPDEALLV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
82
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
24.1491
Exp number, first 60 AAs:
24.06373
Total prob of N-in:
0.08674
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 82
