Strain
Porcine_KY406735
(Region: USA; Strain: Porcine respiratory coronavirus strain PRCV/USA/Minnesota-46140/2016, complete genome.; Date: 1-Nov-16)
Gene
membrane protein
Description
Annotated in NCBI,
membrane protein
Location
GenBank Accession
Full name
Membrane protein
Alternative Name
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Sequence
CDS
ATGAAGGTTTTGTTGATATTGGCGTGTGTGATTGCATGCGCATGTGGAGAACGCTATTGTGCTATGCAAGACACAGGTTTTTCATGTCGCAATAGCACAGTGTCTGATTGTGAGTTATGCTTCAACGGAGGCGATCTTATTTGGCATCTTGCAAACTGGAACTTCAGCTGGTCTATAATATTGATCATTTTTATTACTGTGCTACAATATGGAAGACCTCAATTTAGCTGGTTCGTGTATGGCATTAAAATGCTTATAATGTGGCTATTATGGCCCATTGTTTTGGCTCTTACGATTTTTAATGCATACTCGGAATACCAAGTTTCCAGGTATGTAATGTTCGGCTTTAGTATTGCAGGTGCAATTGTTACATTTGTACTCTGGATTATGTATTTTGTAAGATCCATTCAGTTATACAGAAGGACTAAGTCCTGGTGGTCCTTCAACCCTGAAACTAATGCAATTCTTTGCGTTAGTGCATTAGGAAGAAGCTATGTGCTTCCTCTTGAGGGTTTGCCAACTGGTGTCACTCTAACTCTGCTTTCAGGGAATTTATACGCTGAAGGGTTTAAAATTGCCGGTGGTATGAACATCGACAATTTGCCAAAATATGTAATGGTTGCATTACCCAGCAGGACTATAGTCTACACACTTGTTGGCAAGAAGTTGAAAGCAAGTAGTGCGACTGGATGGGCTTACTATGTAAAATCTAAAGCTGGTGATTACTCAACAGAGGCAAGAACTGATAATTTGAGTGAGCAAGAAAAATTATTACATATGGTATAA
Protein
MKVLLILACVIACACGERYCAMQDTGFSCRNSTVSDCELCFNGGDLIWHLANWNFSWSIILIIFITVLQYGRPQFSWFVYGIKMLIMWLLWPIVLALTIFNAYSEYQVSRYVMFGFSIAGAIVTFVLWIMYFVRSIQLYRRTKSWWSFNPETNAILCVSALGRSYVLPLEGLPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKKLKASSATGWAYYVKSKAGDYSTEARTDNLSEQEKLLHMV
Summary
Function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Similarity
Belongs to the alphacoronaviruses M protein family.
Keywords
Glycoprotein
Host Golgi apparatus
Host membrane
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Feature
chain Membrane protein
Uniprot
Proteomes
PRIDE
Pfam
PF01635
Corona_M
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Virion membrane
Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Host Golgi apparatus membrane Largely embedded in the lipid bilayer. With evidence from 1 publications.
Topology
Length:
261
Number of predicted TMHs:
3
Exp number of AAs in TMHs:
74.0589599999999
Exp number, first 60 AAs:
17.71184
Total prob of N-in:
0.32944
POSSIBLE N-term signal
sequence
outside
1 - 45
TMhelix
46 - 68
inside
69 - 74
TMhelix
75 - 97
outside
98 - 111
TMhelix
112 - 134
inside
135 - 261
