Strain
Avian_KY407556
(Region: China; Strain: Infectious bronchitis virus strain gammaCoV/ck/China/I0114/14, complete genome.; Date: 2014)
Gene
ORF3c
Description
Annotated in NCBI,
ORF3c
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGAATATGTTGAATAAGTCGCTAGAGGAGAATGGTAGTTTTCTAACAGCAGTTTATGTCTTTTGTGGATTTGTAGCACTCTACTTACTAGGTAGAGCACTACAAGCTTTTGTACAAGCAGCTGATGCTTGTTGTTTATTTTGGTATACATGGGTAGTAGTCCCGGGAGCTAAGGGCACTGCATTTGTGTATAAACATACATATGGTAGAAAATTTAACAATCCGGAGTTAGAACACGTTATTGTTAACGAGTTCCCGAAGAACGGTTGGAATAATAAAAGTCTACCAAATTTTCAAGATGTCCAACGAGACAAATTGCACCCTTGA
Protein
MNMLNKSLEENGSFLTAVYVFCGFVALYLLGRALQAFVQAADACCLFWYTWVVVPGAKGTAFVYKHTYGRKFNNPELEHVIVNEFPKNGWNNKSLPNFQDVQRDKLHP
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.
Similarity
Belongs to the gammacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF03620
IBV_3C
Interpro
IPR005296
IBV_3C
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
108
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
38.85057
Exp number, first 60 AAs:
35.49699
Total prob of N-in:
0.74431
POSSIBLE N-term signal
sequence
inside
1 - 12
TMhelix
13 - 35
outside
36 - 44
TMhelix
45 - 64
inside
65 - 108
