Strain
Bat_KY799179
(Region: Canada; Strain: Myotis lucifugus coronavirus, complete genome.; Date: 10-Nov)
Gene
replicase protein1a
Description
Annotated in NCBI,
replicase protein1a
Location
GenBank Accession
Full name
Replicase polyprotein 1a
Alternative Name
ORF1a polyprotein
Sequence
CDS
ATGGCAAGCAATCATCTAACACTGGCTTTTGCCAGTGATATGGAAGTTTCAGCTATAGGCTTTGGGTCCATTAATGAAGCCGTATCATTTTACAGTGATGCCGCCATTGATGGTTTTACCCAATGCCGTTTTGTTGCTGCAGGTCTCGCTAACACTGTCGAGGGTGTTGAACCCTCTGACTTTGTTATGGTTGTGACAGGTGTCACCCAATTGCGAGCCTACATTGACACTTTTGGTAGCCGGCCTGCTAATTTACGCGGCTGGTTGCTGTTTTCTAATTCCAATTATTTCCTTAGTGAGATGGAGCTTATTTTTGGTCGCCGGGGTGGTAACACCATCTATGTTGACCAGTACCTCTGTGGTGCGGATGGTAAGCCTGTCGTCCCTGAGGAATTTTGGGATTTTAAGGACTATTTTGCTGATGATGATCAGGTTGTGGTTAATGGCACTACTTACGTTAAGGCTTGGGTGGTTGAACGCGCAAATGTTGCTTATGAAGCTCAGAATGTGACTGCTATCAATGGCATTACATATTGCGCCAAAATCCCCCATACTTTGCCTGATGGGAGTGTTGTCCGTGTGGCCCGTAAACCTAAGATCAAAAAGTCAATAGTCCTTTCTGATGTTTACAAGCTTTTGTTAGAGGGCTTGGGTGCACCATTTGTTAAGAATGGTGACACACTTGCATCTATTCTCACTGAACCTGTGTTTTTGCATGCGCTCGTTAAGTGTACTTGTGGCAACACCATGTGGACCGTTGGTGACTGGAGTTGCTACAAGTCATTGTGTTGCGGTGTAGTTTGCAAACCACTTTGTAACGTTGCTGGCATTGTTAATCCTGGTTCAGCTGTTGTCACCCGTACTGGATTAGGTTCTGGTATTAAGTACTACTGTGGCATGTTCTTGCGTCACATTCTTGACGTTGATGGCGTTTCTGTGTGGCGTGTGATCAGATTACAGAGTGCAGGCGAGTCTGTGACTTCGACCAACTTTGAGGAGTTTGGTGATGTGTGCCCTATGGACACATGTCACTATTCTCTAGATTCAAGGCTGGCTGTCATGTTCAAACTTAACCTGCTTTCAGGTGACTTTTGTGCTGAGGTGCGTCAGGCTATTGCTAGCGGTGTTTTCAGCGTTGGTAATTTCATTTGTGATGTTACTGATGATGTGCTTGGAAAACCATGGTTCTTGAAGAAACTTGGTGTTCTAGCAGATGCTGCCTGGACCGCCTTTGTTGCCAGTCTTCGTAAAATTAAAGTTATGAGTTCGCAGCTTGTGGATCTTGCTAAAGCATTAGCGTGTGCTAGTGTTTCTGTTATTAACAGGTGCCTGGTTCTTGCTGCTGATGTGCCTCCTATTTTCAAGGAGTGTTTTGCTAAGTTTGTCAGTGCTATTGCAGCTCTGTTTAAGTCTACTTGTGACACTGTCAAGGTTGCACGTCATTCATATCCAAGGCTTTTTGATTATGTTTTGCTTGATAATCATTTGGTGAAAATGGTTACTCAACGCATTACTGGTAAAAAGCAGGCTGGATTGACTGAGGCTACATTTGCTGATGTAATTCTGGGTGCCACTACTAATGTGACGTCAGACCGTACTGAGGCTTGTAATGTTGGCCTTGTGCTTTGTGACTATGACGTGCCCGTTCTGAATACTGGATACACTGCCATTATTGGTGGTAAGGCCTTTTTCTGTAGTGAAGGTTACTATAGGTTTATGGCTACCCCCAATGTTGTGCTTGATGAACCTGTGTTTCGTGCAGCGGCAGAATTGAATCCAGTTTTTGAGTGCGAAAAGCCTGATGGTTTTCCAGTTCTCGTTGCATCCGATGTGGCTGAACTCTGTGTTAAAGTTGATCAGCTCCTGCCCAACTATAGTACCTCATACAAGCGTTATGAGAGTGTTATACGTGGTGAGCAGTGCTTTATACGCTGTATTTACGATTTTAGAGCACCATCATTTATTAGGAAAGGTGATGATGCTGAGAAATTTGTGAAACAATGTGAAGTGCTTGTTAGCAACCCTCTGTTCTTTGAGTTTTATACTCAGGCGCATGAGGCTGTTGACCTTGATCAGTATGTTAACACAGCTTGTACCTTAGATGGTTTTTCGCATATGGCTCCTGCTGTACCCAAGCCACATCCTTTGTTTTTGCAAATTGATGGCGGTGCCATATGGCGAAGTGTTGTTCGCCGTGTGAGCGCCGTAGCAGATTTTGTCAGAAACCTTAAGGTTAGTTTTGGTTTGGAGGGCATTATTGTCTCAGCAGCTAGGAAATTCAAACAATGGGCTAAACTTTTGGCTCAGATGTATAATGAATTTCTTAACTCTGTTTCAGCTGCCATTTATATTGCAGGGGTTAAGTTTATACATTATGCCACCACTGTGCCACAGCTTGCCTATAATGGTTGCCTTTATGCTCTTAAAAAGACATATGCTGCAACTGTAGGACTTCAAACCGAAGAGGGTATTGACAGCTTTTATGCTTTTGACCATTGTCAATTACCTGTAACTCCTAGGTTGCTGCAGGTTGAAGATGTCAATTTAGAAGAAGCTGATTTTAAACCCCCAGTAGGTGGTGGTTGTGTGGCAGTGATTAATGGTTACTCATTTTATGTGGAAGGTGATTCTTATTACCCCACTGATTGTAGTGCTATTCATTCACTGCGCTTTAGAAAGCTTGGTGGTGCTGGTGTTGCTTTTTCAGAAGATGTGGCAGTTAAAACTATTGATCCTGTCTACAAGGTTCGACTCGATTTTGAATTCGAAGATGATTCAGTTGTTGCACTTTGCAAGAAGACTATTGGCAAGTCCATTAAGTTTAATGGTACAGAATGGGACAAATTTGTCGCCATTTTGGAAACTGCACTAGGTGTTCTTGCAAAGCATGTTACGTTGCCACCATACTTCATTTATGACGACCATGGTGGCAAGAACTTATCACGCACTGTAGTGGTTTCACAATGGCCACCAGCTGATGTTGACGAGTCTTGTGATGACAGTGACGACGATGATGACTCCGACCATGAAGCAGACGAAGAATCCTCTGCTGAGCATGATGATGATCCCGAAAGTGCATCAACAGATGAACAGTTGATGGGCCAGGATACTGCACCTGATAGTGCATCGACAGATGAAAGTCATGAGACCGAACCTAATGGTGCGTCTTTAGATGAAGATCTGTCTGCAAAACAGGAAGAGGCTCTAAATGCTTTGGACAATGCTATTGGTAGTGCATCAGCTGCCACAGAAGAAGAAGAAGTTAATGATGCACTGTCTTTTATGACCGAGTCATCACCAAAACCTTGTGAGCCTACTAGCGACACTTTTGCATATCCTTTTAAGGATTATAATGGTGTCAAGGTGCTAGACCAACAGAGTAACAATTGCTGGGTTAACTCAACTTTACTCCAGTTGCAGTTGCTTGGTGTCATCGGTGATGACTCCGCAATGGCATTGTTTAAAGTTGGTAGAGTTGGACCTATGGTTAAGCGTTGCTACGAAGCTGTTGGCGCAATTAAAGGCTCTTTAGGTGACGTGTCTCAGTGTATGGAAGTTTTGTTACGTGATGTCAAAACTCTTACTGTACACTGTGATACTGTTTGTGACTGTGGGTCTGGCTCTAAGACCTTTGTTGGCTGTGCTTTTAGGTTTGAGCCTACGACGGAACCGTTTCCATATGGTTGTTGTCAGAATTGCAAACAGGTTTTATTGCATACCATTACTTCTATTAGTGGTACTGGTGTGTTTTGTCGTGAACCTACTCCTTTTGACATCAGTGTTATGCCAATTCGACCATTGTGTGCTGCAAATTATGTTGGCGCTGTTGATGGTGGTCATTATATGACTAACATATATACCAACAATGTTGCGGTGGACGGTCATGGTGTACACGGGATTGCAAACACAGGCCTTAACACTATTTGTGTTAAGGATGTGGATTGGTCTAGAGCTATTAAACATGAACTCATTCGTGTTGAAAAGCCTAAAAAGGATGTCAAGCCAGAACCACCAGTTAAACCTTTGAATGCTAAAGTTGATGGTTTGAAACCATTTGTTAGTTACAAAGGTGTTGAATTCTATCAGGGTGCTTTTAAGGACCTCCTTGAGTTGTCATTTGACTTTGTTGTAAACGCAGCAAATGAGCAATTGTCACATGGTGGTGGTGTTGCACGTGCTATAGATGAACATACTGGTGGTGAACTGCAAAGTTTGTCTGACAGATATGTTAAAGCCGTAGGTCCTCTAAAGGTTGGCACAGGTGCTTACATTAAATGCAAAGCATTTGATGTTTTTAATGTTGTAGGTCCACGCAAGGGTAAACATGCTAAGGATTTGCTTGTCAAGTCTTATGACAGTGTCTTTAGTGTGCCTGGCGTGCCACTTATGCCATTATTGAGCATTGGTATATTTAGGGTACCCATTGAAGATTCTTTGAGTGCTCTATTTGCCTGTGTTGGAGATCGCGTTTGCAAGTGTTTTTGTTATTTGGACGCTGAGCGTGACGCTATTCTGCAATATGTTGCTGGGCTTTCGGTTGTCGACGAGGTGGAAGTTAAGCAGGAAACTGCTTTTACTCCTAGGCGTATGGAGGGCTCATGTAACTTTTATGACTGCAACCCTAAAGCATTGGTTGACAATGGTGTGACAAGGTTTGTTGTTTTTACCAAACCAAGTCTTGATTTTTGTGACACCACCAAAGTGCTAGACACCTACTTTAAAAGTTTGTTAACTAATCTTGTAAAGGATTATGTTAGCACTCTTAAGGGTAAGGTTGTGCCAGCTGGTAATTGCGTTACACTGCGTTGCACTGATAGTGTTAGTGTTACATTTGTTGTTTTGCCTACAGATGACGACCCCAATTTTGAAACTAATGCAAAGCGTGCTTTTCAAAAATGTCTTAAACTTAAAGGTACATGTGTTTATGCAACCACTGATGCCGATGTTTTGAGACGTATTGTCAAGCACTCATGCTTTGGTTTTATCGCTAATGACAATGTTATTAGTGCAGTTTTCACGGATGGTCAATTTAGGGTTGAAGTTACACAAGACCAGCGTACTTACAGTGTTAAATCCTTAGATGCTAGTAAAACAATGGGCGAACAGTTGGGTACATGTAGTGTTGATAACACTAATGTCTCTGATCAGCGTCCAACTAGTGATATTTCTAAGGTTACTGTTGCTCCTGCTGTTGATTGGGACGTGCATTATGGTTTTGTTGGCGCAGCTAGTTTTCATATTTTGAATCATGAAGCATTCGAATATCCTAGCATCGTGCAAAATGGTAAGCGTGTTCTTAAAACTAGTGACAACAATTGTTGGGTTAATGCTGTATGTTTACAACTACAGTTTGCTAATGCCAAATTTGTTGGAACTGGTCTTCAAACATTGTGGGATGAGTACCTGGTTGGTAATGTTGCTGGCTTTGTACACTGGTTGTATTGGCTAGCAGGCGTTCAGAAGGGTGATCCTGGTGATGCTGAGGACACTTTGAATTTAATTTCTAAGTTTCTTCAGTCTCAGGGACACGTGGTTGTGGATCGCACTACAGTTGATTCCTGCTGTAGCTCCCAGCGCACACTTGTTACACCAGTTGTTAATGGTAGTATTTTGCGCATGGGTGTTGACGATGGTGCGTGTAAACATGGTTCTACTTTTATAAATAAGGTTGTCAGTATTGATGGTACTGTAATCTTAGTTAATGTTGGACCACCAATTTCTAGTGCACCTACTTCTTTTATACAGGGTTTGTCTTATACATCATTCAACAATACAGTTGGAGGTGTCGGACATTATACTGTATATGATAGTACACAGCATGGCTTTTATGATGGTGACGCATTTGTACGTGGTGAGTTGGCTATGCAGCCTGTAACTGCTTTAGTTGCTAGACATAGTCATTACGTTGTTAAAGACCCTGTAAAGTCTTTTGAACAACGTGCTTCTGCAGTTGTTGACAGTCTCAATTTTGCATCTGAGAAGTTTTTCACCTTTGGTGATTTTGTGTCACGTAACGTCATAACAATGTTAGTGTGGTTCTTTAGTTTGCTTTCTTTGCTTCTGAAGTCTGTGCGTCGCAGAGACTTTAGGGTTTTAGCAGGTGCGCCAGAGCGTTCTGGTGTTATAATTAGTCGTAGTATTAAGTATAATGTTAGAGCATTACGCTACTTTATGAGGCTGAAAGCCAAGTGGGTTTGTATGTTTTTGAAGGCCTGTTTCATATTGTATACATGTTATGCTACATGTTTTATGATTATTAGGTTTTCTTTTGTAAGTGACATCTTTTGCAGTGGCGACGTTGATGGTTATGCTAATTCCTCATTTGACAAAAATGCATACTGTGATGGACAGTTGTGCAAGGTTTGTTTGTTTGGTTACGATGAACTAGCAGATTTTCCGCATACAACTGTTGTTTGGGAACATTTAAAAGACCCATTTGTCATAAATGTTATACCCCTATTTTATCTTGGTTTCTTGGCAATTTTTGGTGGGACTGTTACTCGTATAATGGTTTTGTACTTTGTTAGCCAGTATGTTAACATGCTTGGTGCTTACCTTGGTGTACAAGATAGTGTTTGGTTTTTGCAATTCTTTCCATTTGATGTTTTTGGAGATGAGATCGTCGTGCTATTTTTAGTAGTACGCGTGCTTATGTTCCTCAAACATGTGTTGTTTGGTTGCGATAAACCCTCATGTCTGGCTTGCTCTAAGAGTGCAAGGCTGAAGCGTGTTCCAGTTTCCACTATTGTTTCTGGTGCTAATAAGTCCTTCTATGTCAATGCTAATGGAGGTACATCCTTTTGTAAGAAGCATAATTTTTATTGTGTTAATTGTGACTCTTATGGTTTGGGTTGTACTTTCATTAATGACGTTGTTGCAGCTGAAGTCGGAAATGTTACTAAGTTAAACGTCCAGGCAACAGGTCCTGCCTTTGTTGAGATTGACAAAGTCGAATTTAACAATGGTTTTTACTACTTGTATAGTGGTAATACCTTTTGGAAATACAATTATGACATTACTGATAGTCGTTATAGTTGTAAAGAAGCCCTGAAAAAGTGTAACGTAGCTGCTGACTTCATAATTTGTAATAACACAGGCTCTAATATGGCGCAAGTAAAGAATGCTTGTGTTTATTTTAGCCAATTGTTGTGTAAACCTATTAAGATTGTAGATTCTACACTTGTGTCAACTTTGGGTGTTGATTTTAGTACATCTATTCATAGTGCTTTTGTTGAAATCCTAACCGATAGTTTCGGCAAAGATCTTTCAAATTGCACTACTATGTCACAGTGTAGGGCTACACTTGGGTTTGATGACATTTCTGATGAGGACTTTACAGGTGCCGTTGCTAATGCCCATAGATATGGCTTGCTTTTAACAGACATTTCATTTAATAATTTTATTACCTCCTATGCTAAGCCAGAGGAGAAGATGTCTGTACATGACTTGGCCATTTGTATGCGTAGCGGTGCTCGTGTTGCTAATCACAATGTGCTTGTCAAGGAAAATGTTCCTGTTGTGTGGTCTGCTGAAGCATTTAACGCATTATCTGAAGAGTCTCGCAAGTATGTTGTTAAGACTTCTAAGGTCAAAGGCTTGACTTTTATGTTGTCTTTTAACAATGTTCGGATGCACACAACTATACCATCTGTTGCCATTTCAGGTAAAAAGGGTGGTAGTACAGTTTCTGCATTTTTTAAAAACTTGCGTAAGATATTGTGGTGTTCATGTACCATTATTTTGTGCTTATTCTTTGTTACGTCGTTGTGGAACTTTGCAGAAAGTTACCATAGTGGTAGTGAGTTCGGTTATAAGTACATTGAGAATGGTGCACTCAAAGACTTTTCAGGACCACTTGATTGTGTGCACAATATTTTTGATGACTTTATGGCCTGGCATCATGCTAAGTATGGTGTTCAACCTATTAATAGCAGGCGTTGTCCTATTGTTGTTGGCGTTGATGAAAACGTCCGCACAATACCTGGTGTCTCTTCTGGTGTTATGCTTGTTGGTAAAACATTGGTTTTTGCTGTCAAGTCTGTGTATAGTTCTGCAGGTCTATGTTACGATGAGTTTGGAGCAGCCGCACCCGAACAGTGTTTGTTCAATTCTGCTTGTACGACGCTGAAAGGTCTTGGTGGTACTTCTACTTATTGTTACCGTAGTGGTCTGGTCAGTGATAGTGGTCTCTACAGAGATTTGCTGCATGACAGTCATTACTTTTTGCCTGATGGTAACTATGTTAAATTTCCAGAGGTTATATCACGTGGTTTTGGTTTTAGAACAGTACGTACTGCTGCTACAACATACTGCCGTGTTGGTCAATGTGTTGACTCTAAACAAGGTGTATGTTTTGGACTTGATAGGTTTTTGGTTTATAGTGCAGAGTCTGGCTCTGACTTTGTTTGTGGTACAGGCCTTATGTCATTGTTGTACAACGTTTTTGGTATATTTACACGTTCTATACCAGTTGTTGTACTTTCAGGTCAAATTATGTTCAACTGTGTTGTTGCATTTCTTGCTGTCTCTTGCTGCTTTTTGTTTACTAAGTTTAAGAGGCTTTTCGGTGACATGTCTTTCGGTGTGTTCACTGTTTGTTGCTGTGTCTTGGTAAATAATCTTTCCTATATAATTACTCAGAATTATATGGGTCTTGTTTTCTATACTGTTTTGTATTTCTTCTCCACAAAGACCGTGCGTTATGCTTGGATTTGGCACATAGGTTATTTTGTTGCTTACTTCCTCGTAGCACCATGGTGGCTTTTGGGTATGTTTCTTGCTTCTGCTTTGACAGAGTTTTTGCCGTCAATGTTTAAACTTAAAGTTTCTACCCAACTGTTTGATGGAGAGAAATTCGTTGGTAGTTTTGAGACAGCTGCTATGGGTACTTTTGTTTTAGACATGCGTACCTATGAAAAACTTGTTAATTCAACTCCTGGTGATAAAATACGTCAGTATGCAGCCACCTATAATAAATATAAGTATTATAGTGGTGGCGCCAACGAGGCTGATTATAGATTGGCATGTTTCGCACATCTAGCCAAAGCCATGATGGATTTTGGTTCAAATCACCAGGACATGTTGTACTCACCTCCCACTGTCAGTTATAATTCAACACTTCAAGCTGGGCTTAAAAAGATGGCACAACCTTCAGGTGTTGTTGAGCGCTGTATTGTCCGTGTTAGTTACGGTAACATGGTGCTCAATGGCCTTTGGTTAGGTGACACAGTTTATTGCCCAAGACATGTGTTGGCTGCATCCACTACTACTCATATTGACTATGAACATGCGCTTGCTATTATGAGGTTACATAATTTTTCTATATCTTATGGTAACACATTTTTAGGCGTTGTTGGTTGTTCTATGAAGGGTGCACTTTTGCTTATTAAGGTTGGTCAAAATAATGTTCACACACCTGGTAGTTACACTTTTAGAACACTTAAGCCTGGCGATTCATTTAACATCTTAGCATGTTATGATGGTACAGCTACTGGCGTTTATGGTGTTAATTTGAGAACCAATCATACTATTAGGGGCTCTTTTATTAATGGGGCTTGTGGTTCACCAGGTTTTAACATACATGGTAGCACTGTAGAATTTTGTTATTTACATCAACTAGAGCTTGGCTCTGGTTGTCATGTGGGTAGCGATATGAATGGTGCTATGTATGGTGGATATGAAGACCAACCCTCTTTCCAGATAGAAGGTGTTAGTAACCTTGTATCTGAGAATGTTGTGGCATTTCTTTATGGTGCATTGCTTAATGGATGCAATTGGTGGTTAGACCAGTGTGGTGTTACTGTTGAGGCCTATAATGATTGGGCTCATAGTAATGGCTGTACTAGTTTATCAAGTACAGATTGTTTCACAATATTGGCAGCTAAGACTGGTGTTGAGGTGTCAAGAGTGTTGGCAGCTATACAGCGTCTTAATGTCAATTTTGGTGGCAAAGCTATACTTGGTTACACCTCTTTAACTGACGAGTTTACCGTGGGTGAGATAATTAAGCAGATGTTTGGTGTTAACCTGCAGAGTGGTATTATAAGCCGGTCAGTGCGTAATGTGCTTTTAGTCGGCTTATTTGTCCTACTGTTTTGGTCAGAGTTAGTTATTTATACACCATTTTTCTGGGTTTCTCCAGCTTATATTACACCATTGTTTTTGATTGTCAGTGGTGTTTCTATCTTGTGCATGAGTCTTCTGAAGCATAAAACATTGTTTTTGCAAATGTTTTTGATTCCAGCTGTTATTGCAGTGTCTGCTTACAATCTGGCATATGATTTGGAGATACGCACGTGGATGGCTACTAAGCTGGATTATCATGCCTCTATTCTTAGCTTTAACATTCAGGGTATATTTAACATTATGGTGTGTTGTGTTGTTGTTTGTCTCCATGCATACCGTTGTGTTACTAGATCATCATCTGTTTTCACTATGGTTGTGGCATGTATAACGTCGTGCTATAGTTATGTTATATGTGGTGATGCCCTAAGTGCTGCAATGGCTATTATGCTCAACATCACTGGTAATTGGTTTGTTGGTGCAGGTGCTTATAGGTTGGCAACATATATTGTCTTACTAAACCCTGCACTACCTGCTCTTGTCGGTGATGTTAAGGCTATAGTCTTTGTGTACGTTGCTGTTGGCTATGTTTGTTGTGTGTTTTATGGTATTTTGTACTGGGTTAACAGGTTTTGTAAACTTTCACTTGGTGTTTACGATTTTATGGTTAGCCCAGCTGAATTTAAGTACATGGTTGCTAATGGCTTGAGAGCTCCTACTGGTGCATTTGATTCACTATTTTTGTCTGCACGTTTGCTTGGTATTGGTGGTCAGCGTACCATTAAGATATCAACAGTGCAGTCCAAACTTACTGATGTTAAGTGTACCAATGTGGTTCTAATGGGCTGTTTGTCTAGCATGAACATTCAGGCTAACTCTGCTGAGTGGAATTATTGTGTTGATTTGCACAATAAAATAAACTTGTGCAATGATTTAGAACGTGCACAAGAGTATCTTTTGGCATTGTTGGCATTTTTCTTGTCAAAGAATAGTGCCTTTGGCTTAGATGACCTTTTGGACTCTTATTTTGATAATAACACTGTGCTTCAGGCTGTTGCTACTACATATGCTAACATGCCATCATACATTATGTATGAGAATGCAAGACAGGCATATGAGGAAGCAATTTCAAACCGTTCCTCGCCCCAGTTAATTAAGCAACTTAAGCATGCTATGAATAGGGCTAAGGGGGAGTTTGACCATGAGGCTGCAACTCAGCGTAAGATTGATCGTATGGCTGAACAAGCAGCTGCGCAGATGTTTAAGGAAGCTAGAGCTGTGAACAAAAAGTCAAAGGTTACTAGTGCTATGCATGCCATGTTATTCAGTATGTTGCGCCGTTTGGATATGTCTAGTGTTGACATTATCCTTAATCTCGCTAGAAATGGCACCGTGCCATTATCCATAATACCTGCTTTGTGTGCTACTAGATTGTCAATTATTGTCAGTGACTTTGAGTCATATGCCAAATTGTTTAGAGAAGGTTGCATACATTATGCTGGTACTATATGGTCTGTTGCTGATATTAAGAACAACGATGGTAAACCAGTACATCAGAAGGAAGTGACATCTTCTAATGCTGAGAACTTGAGTTGGCCATTGTGTATTAATGCAGAACGTATAGTTAAGTTACAGAATAACGAAGTTATGCCTGGTAAGCTTAAACAGCGTTCTGTCAAAGCAGAAGGTGATGGTGTTATTGCTGAGGGTAAGGCGCTTTACAATACTGAGAATGGACGTACTTTTATGTACGCATTTCTTGCAGACAAACCTGATCTTAAGGTCGTCAAATGGGAATCTGATGACGGTGTTAAGGTCATTGAGTTGGAACCACCTTGTAAGTTTTTGGTAGACACACCCAACGGACCACATGTAAAATTTTTGTACTTTGTGCGGAATCTTAACACACTTCGACGTGGTGCTGTTCTTGGTTTCGTTGGTGCAACAGTAAGATTACAGGCAGGTAAGCAAACTGAGCAAGTTATGAATTCTTCTCTATTGACTATGTGTGCCTTTTCTACTGATCCAGCTAAGACATATCTTGATGCAGTTAAGAGTGGTGTTAAGCCAATTGGTAACTGTGTTAAAATGTTGGCTAATGGTGCTGGTAACGGACAGGCTATCACTAATGGTGTTGAGGCTAATACTAGTCAAGACTCATATGGTGGTGCGTCTGTTTGTCTGTGGTGTAGAGCTTATGTTGAACATCCAGCTATGGATGGCTTTTGTAAGTATAAAGGCAAGTATGTCCAGGTACCTATTGGAACTGTTGATCCTATTAGGTATTGTCTTGAGAATGAGGTTTGCAAAGTTTGTGGATGCTGGTTGAATAACGGTTGTTCTTGTGATAGGACATCTATTGTCCAAAGCTTTGACAGCAGTTATTTAAACGAGCAAGGGGCTCTAGTGCAGCTCGACTAG
Protein
MASNHLTLAFASDMEVSAIGFGSINEAVSFYSDAAIDGFTQCRFVAAGLANTVEGVEPSDFVMVVTGVTQLRAYIDTFGSRPANLRGWLLFSNSNYFLSEMELIFGRRGGNTIYVDQYLCGADGKPVVPEEFWDFKDYFADDDQVVVNGTTYVKAWVVERANVAYEAQNVTAINGITYCAKIPHTLPDGSVVRVARKPKIKKSIVLSDVYKLLLEGLGAPFVKNGDTLASILTEPVFLHALVKCTCGNTMWTVGDWSCYKSLCCGVVCKPLCNVAGIVNPGSAVVTRTGLGSGIKYYCGMFLRHILDVDGVSVWRVIRLQSAGESVTSTNFEEFGDVCPMDTCHYSLDSRLAVMFKLNLLSGDFCAEVRQAIASGVFSVGNFICDVTDDVLGKPWFLKKLGVLADAAWTAFVASLRKIKVMSSQLVDLAKALACASVSVINRCLVLAADVPPIFKECFAKFVSAIAALFKSTCDTVKVARHSYPRLFDYVLLDNHLVKMVTQRITGKKQAGLTEATFADVILGATTNVTSDRTEACNVGLVLCDYDVPVLNTGYTAIIGGKAFFCSEGYYRFMATPNVVLDEPVFRAAAELNPVFECEKPDGFPVLVASDVAELCVKVDQLLPNYSTSYKRYESVIRGEQCFIRCIYDFRAPSFIRKGDDAEKFVKQCEVLVSNPLFFEFYTQAHEAVDLDQYVNTACTLDGFSHMAPAVPKPHPLFLQIDGGAIWRSVVRRVSAVADFVRNLKVSFGLEGIIVSAARKFKQWAKLLAQMYNEFLNSVSAAIYIAGVKFIHYATTVPQLAYNGCLYALKKTYAATVGLQTEEGIDSFYAFDHCQLPVTPRLLQVEDVNLEEADFKPPVGGGCVAVINGYSFYVEGDSYYPTDCSAIHSLRFRKLGGAGVAFSEDVAVKTIDPVYKVRLDFEFEDDSVVALCKKTIGKSIKFNGTEWDKFVAILETALGVLAKHVTLPPYFIYDDHGGKNLSRTVVVSQWPPADVDESCDDSDDDDDSDHEADEESSAEHDDDPESASTDEQLMGQDTAPDSASTDESHETEPNGASLDEDLSAKQEEALNALDNAIGSASAATEEEEVNDALSFMTESSPKPCEPTSDTFAYPFKDYNGVKVLDQQSNNCWVNSTLLQLQLLGVIGDDSAMALFKVGRVGPMVKRCYEAVGAIKGSLGDVSQCMEVLLRDVKTLTVHCDTVCDCGSGSKTFVGCAFRFEPTTEPFPYGCCQNCKQVLLHTITSISGTGVFCREPTPFDISVMPIRPLCAANYVGAVDGGHYMTNIYTNNVAVDGHGVHGIANTGLNTICVKDVDWSRAIKHELIRVEKPKKDVKPEPPVKPLNAKVDGLKPFVSYKGVEFYQGAFKDLLELSFDFVVNAANEQLSHGGGVARAIDEHTGGELQSLSDRYVKAVGPLKVGTGAYIKCKAFDVFNVVGPRKGKHAKDLLVKSYDSVFSVPGVPLMPLLSIGIFRVPIEDSLSALFACVGDRVCKCFCYLDAERDAILQYVAGLSVVDEVEVKQETAFTPRRMEGSCNFYDCNPKALVDNGVTRFVVFTKPSLDFCDTTKVLDTYFKSLLTNLVKDYVSTLKGKVVPAGNCVTLRCTDSVSVTFVVLPTDDDPNFETNAKRAFQKCLKLKGTCVYATTDADVLRRIVKHSCFGFIANDNVISAVFTDGQFRVEVTQDQRTYSVKSLDASKTMGEQLGTCSVDNTNVSDQRPTSDISKVTVAPAVDWDVHYGFVGAASFHILNHEAFEYPSIVQNGKRVLKTSDNNCWVNAVCLQLQFANAKFVGTGLQTLWDEYLVGNVAGFVHWLYWLAGVQKGDPGDAEDTLNLISKFLQSQGHVVVDRTTVDSCCSSQRTLVTPVVNGSILRMGVDDGACKHGSTFINKVVSIDGTVILVNVGPPISSAPTSFIQGLSYTSFNNTVGGVGHYTVYDSTQHGFYDGDAFVRGELAMQPVTALVARHSHYVVKDPVKSFEQRASAVVDSLNFASEKFFTFGDFVSRNVITMLVWFFSLLSLLLKSVRRRDFRVLAGAPERSGVIISRSIKYNVRALRYFMRLKAKWVCMFLKACFILYTCYATCFMIIRFSFVSDIFCSGDVDGYANSSFDKNAYCDGQLCKVCLFGYDELADFPHTTVVWEHLKDPFVINVIPLFYLGFLAIFGGTVTRIMVLYFVSQYVNMLGAYLGVQDSVWFLQFFPFDVFGDEIVVLFLVVRVLMFLKHVLFGCDKPSCLACSKSARLKRVPVSTIVSGANKSFYVNANGGTSFCKKHNFYCVNCDSYGLGCTFINDVVAAEVGNVTKLNVQATGPAFVEIDKVEFNNGFYYLYSGNTFWKYNYDITDSRYSCKEALKKCNVAADFIICNNTGSNMAQVKNACVYFSQLLCKPIKIVDSTLVSTLGVDFSTSIHSAFVEILTDSFGKDLSNCTTMSQCRATLGFDDISDEDFTGAVANAHRYGLLLTDISFNNFITSYAKPEEKMSVHDLAICMRSGARVANHNVLVKENVPVVWSAEAFNALSEESRKYVVKTSKVKGLTFMLSFNNVRMHTTIPSVAISGKKGGSTVSAFFKNLRKILWCSCTIILCLFFVTSLWNFAESYHSGSEFGYKYIENGALKDFSGPLDCVHNIFDDFMAWHHAKYGVQPINSRRCPIVVGVDENVRTIPGVSSGVMLVGKTLVFAVKSVYSSAGLCYDEFGAAAPEQCLFNSACTTLKGLGGTSTYCYRSGLVSDSGLYRDLLHDSHYFLPDGNYVKFPEVISRGFGFRTVRTAATTYCRVGQCVDSKQGVCFGLDRFLVYSAESGSDFVCGTGLMSLLYNVFGIFTRSIPVVVLSGQIMFNCVVAFLAVSCCFLFTKFKRLFGDMSFGVFTVCCCVLVNNLSYIITQNYMGLVFYTVLYFFSTKTVRYAWIWHIGYFVAYFLVAPWWLLGMFLASALTEFLPSMFKLKVSTQLFDGEKFVGSFETAAMGTFVLDMRTYEKLVNSTPGDKIRQYAATYNKYKYYSGGANEADYRLACFAHLAKAMMDFGSNHQDMLYSPPTVSYNSTLQAGLKKMAQPSGVVERCIVRVSYGNMVLNGLWLGDTVYCPRHVLAASTTTHIDYEHALAIMRLHNFSISYGNTFLGVVGCSMKGALLLIKVGQNNVHTPGSYTFRTLKPGDSFNILACYDGTATGVYGVNLRTNHTIRGSFINGACGSPGFNIHGSTVEFCYLHQLELGSGCHVGSDMNGAMYGGYEDQPSFQIEGVSNLVSENVVAFLYGALLNGCNWWLDQCGVTVEAYNDWAHSNGCTSLSSTDCFTILAAKTGVEVSRVLAAIQRLNVNFGGKAILGYTSLTDEFTVGEIIKQMFGVNLQSGIISRSVRNVLLVGLFVLLFWSELVIYTPFFWVSPAYITPLFLIVSGVSILCMSLLKHKTLFLQMFLIPAVIAVSAYNLAYDLEIRTWMATKLDYHASILSFNIQGIFNIMVCCVVVCLHAYRCVTRSSSVFTMVVACITSCYSYVICGDALSAAMAIMLNITGNWFVGAGAYRLATYIVLLNPALPALVGDVKAIVFVYVAVGYVCCVFYGILYWVNRFCKLSLGVYDFMVSPAEFKYMVANGLRAPTGAFDSLFLSARLLGIGGQRTIKISTVQSKLTDVKCTNVVLMGCLSSMNIQANSAEWNYCVDLHNKINLCNDLERAQEYLLALLAFFLSKNSAFGLDDLLDSYFDNNTVLQAVATTYANMPSYIMYENARQAYEEAISNRSSPQLIKQLKHAMNRAKGEFDHEAATQRKIDRMAEQAAAQMFKEARAVNKKSKVTSAMHAMLFSMLRRLDMSSVDIILNLARNGTVPLSIIPALCATRLSIIVSDFESYAKLFREGCIHYAGTIWSVADIKNNDGKPVHQKEVTSSNAENLSWPLCINAERIVKLQNNEVMPGKLKQRSVKAEGDGVIAEGKALYNTENGRTFMYAFLADKPDLKVVKWESDDGVKVIELEPPCKFLVDTPNGPHVKFLYFVRNLNTLRRGAVLGFVGATVRLQAGKQTEQVMNSSLLTMCAFSTDPAKTYLDAVKSGVKPIGNCVKMLANGAGNGQAITNGVEANTSQDSYGGASVCLWCRAYVEHPAMDGFCKYKGKYVQVPIGTVDPIRYCLENEVCKVCGCWLNNGCSCDRTSIVQSFDSSYLNEQGALVQLD
Summary
Function
The non-structural protein 1 (nsp1) protein plays a role in the inhibition of host interferon and pro-inflammatory cytokines production. Suppresses host RELA/p65 activation by blocking NFKBIA phosphorylation (PubMed:28715653). Targets also the RLR pathway downstream of the IRF3 activation by targeting host CREBBP to proteasomal degradation (PubMed:26773386).
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Catalytic Activity
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit
3CL-PRO exists as monomer and homodimer. The 3 peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Produced by conventional translation.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
3D-structure
Activation of host autophagy by virus
Host cytoplasm
Host membrane
Host nucleus
Host-virus interaction
Hydrolase
Inhibition of host innate immune response by virus
Inhibition of host IRF3 by virus
Inhibition of host NF-kappa-B by virus
Inhibition of host RLR pathway by virus
Membrane
Metal-binding
Modulation of host ubiquitin pathway by viral deubiquitinase
Modulation of host ubiquitin pathway by virus
Protease
Repeat
Ribosomal frameshifting
RNA-binding
Thiol protease
Transmembrane
Transmembrane helix
Ubl conjugation pathway
Viral immunoevasion
Zinc
Zinc-finger
Feature
chain Replicase polyprotein 1a
Uniprot
EMBL
Proteomes
PRIDE
Pfam
Interpro
IPR014828
NSP7
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR008740 Peptidase_C30
IPR037204 NSP7_sf
IPR018995 RNA_synth_NSP10_coronavirus
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR038123 NSP4_C_sf
IPR037230 NSP8_sf
IPR013016 Peptidase_C30/C16
IPR036499 NSP9_sf
IPR014829 NSP8
IPR011050 Pectin_lyase_fold/virulence
IPR002589 Macro_dom
IPR014827 Viral_protease
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR008740 Peptidase_C30
IPR037204 NSP7_sf
IPR018995 RNA_synth_NSP10_coronavirus
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR038123 NSP4_C_sf
IPR037230 NSP8_sf
IPR013016 Peptidase_C30/C16
IPR036499 NSP9_sf
IPR014829 NSP8
IPR011050 Pectin_lyase_fold/virulence
IPR002589 Macro_dom
IPR014827 Viral_protease
SUPFAM
Gene 3D
ProteinModelPortal
PDB
5HYO
E-value=7e-155 Score= 482 Identity=73.18%
Cov(Q)=7.26% Cov(P)=100.33%
3D Structure
Ontologies
GO
GO:0030430 C:host cell cytoplasm
GO:0033644 C:host cell membrane
GO:0042025 C:host cell nucleus
GO:0036459 F:thiol-dependent ubiquitinyl hydrolase activity
GO:0039548 P:suppression by virus of host IRF3 activity
GO:0008270 F:zinc ion binding
GO:0019082 P:viral protein processing
GO:0016021 C:integral component of membrane
GO:0039520 P:induction by virus of host autophagy
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039648 P:modulation by virus of host protein ubiquitination
GO:0039644 P:suppression by virus of host NF-kappaB transcription factor activity
GO:0019079 P:viral genome replication
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0008242 F:omega peptidase activity
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0033644 C:host cell membrane
GO:0042025 C:host cell nucleus
GO:0036459 F:thiol-dependent ubiquitinyl hydrolase activity
GO:0039548 P:suppression by virus of host IRF3 activity
GO:0008270 F:zinc ion binding
GO:0019082 P:viral protein processing
GO:0016021 C:integral component of membrane
GO:0039520 P:induction by virus of host autophagy
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039648 P:modulation by virus of host protein ubiquitination
GO:0039644 P:suppression by virus of host NF-kappaB transcription factor activity
GO:0019079 P:viral genome replication
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0008242 F:omega peptidase activity
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host cytoplasm
Host nucleus
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 2 publications.
Host nucleus
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 2 publications.
Topology
Length:
4160
Number of predicted TMHs:
14
Exp number of AAs in TMHs:
385.92883
Exp number, first 60 AAs:
0.00903
Total prob of N-in:
0.00069
outside
1 - 2001
TMhelix
2002 - 2021
inside
2022 - 2063
TMhelix
2064 - 2086
outside
2087 - 2149
TMhelix
2150 - 2172
inside
2173 - 2191
TMhelix
2192 - 2214
outside
2215 - 2825
TMhelix
2826 - 2848
inside
2849 - 2868
TMhelix
2869 - 2891
outside
2892 - 2900
TMhelix
2901 - 2923
inside
2924 - 3354
TMhelix
3355 - 3377
outside
3378 - 3380
TMhelix
3381 - 3400
inside
3401 - 3406
TMhelix
3407 - 3426
outside
3427 - 3440
TMhelix
3441 - 3463
inside
3464 - 3475
TMhelix
3476 - 3498
outside
3499 - 3512
TMhelix
3513 - 3535
inside
3536 - 3539
TMhelix
3540 - 3562
outside
3563 - 4160
