Strain

Avian_LC364342 (Region: United Arab Emirates; Strain: Falcon coronavirus UAE-HKU27 988F genomic RNA, complete genome.; Date: 2013/12/5)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

LC364342(+):23090-23746

GenBank Accession

BBC54824.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCTGAGTCACAGGAGTGGCAAGTCATTGTTTTTATTATTATTATATGGGCCCTAGGAGTAATCCTCCAAGGAGGCTATGCTACTAGGAACCGTATAATTTACATTATTAAACTGATTCTGCTTTGGTTGCTGCAGCCTTTTACTCTAGTTGTCACAATTTGGGCAGCTGTTGAGAATGGCAATAAGAAAACCGATGCAGTCTTTATCATTTCAGTCATATTCGCAGTCCTAACCTTCATCTCTTGGCTTAGGTACTGGTATGACTCTATCAGACTCGTTATGAAAACACACTCTGCCTGGAGCTTTTCACCTGAAAATAGACTTCTTGCAGGTATTATGGACCCATTAGGCAATTGGCGGTGCATACCAATTGACCATATGGCACCAATTCTGGCACCAGTCGTTAAGCACGGCAAGCTCAAGCTACATGGGCAAGAGCTGGCTTCTGCTGTACCAGTCACATCTCCACCAAAAAGTATGATAGTAGTGTCGCCATCCGACACTTTCCATTATACTCTTAAGAAAACTATCGAGTCCACGGATGATCGTGACCTCGCTGTACTAATTTATCAGGGTGACCGTGCCTCAAACGCTGGTTTACACTCCATTACAACTTCCGGCTCAGGAAACGCCAGGCTGTATAAGTACATATAA

Protein

MSESQEWQVIVFIIIIWALGVILQGGYATRNRIIYIIKLILLWLLQPFTLVVTIWAAVENGNKKTDAVFIISVIFAVLTFISWLRYWYDSIRLVMKTHSAWSFSPENRLLAGIMDPLGNWRCIPIDHMAPILAPVVKHGKLKLHGQELASAVPVTSPPKSMIVVSPSDTFHYTLKKTIESTDDRDLAVLIYQGDRASNAGLHSITTSGSGNARLYKYI

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A0U1UZF0

EMBL

KF975407 KJ669722 KJ940498 KR265091 AIB54164.1 AJP08745.1 + More
AJP08750.1 ART35345.1

Pfam

PF01635 Corona_M

Interpro

IPR042550 GAMMA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

A0A0U1UZF0

Ontologies

GO:0055036  C:virion membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0044178  C:host cell Golgi membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

218

Number of predicted TMHs:

Exp number of AAs in TMHs:

63.5133799999999

Exp number, first 60 AAs:

42.6555

Total prob of N-in:

0.06060

POSSIBLE N-term signal

sequence

outside

1 - 9

TMhelix

10 - 29

inside

30 - 35

TMhelix

36 - 58

outside

59 - 67

TMhelix

68 - 87

inside

88 - 218