Strain

Avian_LC364345 (Region: United Arab Emirates; Strain: Quail coronavirus UAE-HKU30 411F genomic RNA, complete genome.; Date: 2013/6/23)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

LC364345(+):23008-23661

GenBank Accession

BBC54854.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCTGAGGCAGATGAGTGGCAAATTATTGTATTTATTGTGATCATATGGGCGCTAGGCGTCATCCTCCAAGGAGGCTATGCCACGCGCAACCGTATGGTCTATGTAATTAAGCTTATCCTGCTCTGGCTGCTCCAACCTTTCACTCTTGTAGTGACTATTTGGACAGCAGTAGATAACGGAGCCAAAAAGGACGCAGTCTTTATTGTGTCCATAATCTTTGCCGTACTAACCTTCCTTTCATGGGCTAGATATTGGTACGACTCAATTCGCTTACTAATGAAAACCAGATCTGCATGGGCACTCTCACCAGAGAGCAGACTCCTTGCAGGAATTATGGATCCAATGGGTACATGGAGGTGCATTCCCATCGACCACATGGCTCCAATTCTCACACCAGTCGTTAAGCATGGCAAGCTCAAGTTACATGGACAAGAGCTGGCTAATGGCATATCAGTTAAAAACCCACCACAGGATATGGTGATAGTGTCACCAAGTGACACCTTTCACTACTCTTTTAAGAAATCTGTGGAGTCAAACAACGATCCAGAATTCGCTGTTCTGATATACCAGGGCAACCGCGCTTCAAACGCTGGACTCCACACCATAACCATTCCAAAAGGAGGTGACGCTCTCCTGTATAAGTATATGTAA

Protein

MSEADEWQIIVFIVIIWALGVILQGGYATRNRMVYVIKLILLWLLQPFTLVVTIWTAVDNGAKKDAVFIVSIIFAVLTFLSWARYWYDSIRLLMKTRSAWALSPESRLLAGIMDPMGTWRCIPIDHMAPILTPVVKHGKLKLHGQELANGISVKNPPQDMVIVSPSDTFHYSFKKSVESNNDPEFAVLIYQGNRASNAGLHTITIPKGGDALLYKYM

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A1U9WSN4

EMBL

KX434788 AQY55870.1

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M
IPR042550 GAMMA_CORONA_M

ProteinModelPortal

A0A1U9WSN4

Ontologies

GO:0055036  C:virion membrane
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0044178  C:host cell Golgi membrane
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

217

Number of predicted TMHs:

Exp number of AAs in TMHs:

63.51655

Exp number, first 60 AAs:

42.66741

Total prob of N-in:

0.03633

POSSIBLE N-term signal

sequence

outside

1 - 9

TMhelix

10 - 27

inside

28 - 33

TMhelix

34 - 56

outside

57 - 65

TMhelix

66 - 87

inside

88 - 217