Strain
Fish_MF593268
(Region: South Africa; Strain: Middle East respiratory syndrome-related coronavirus strain Neoromicia/5038, complete genome.; Date: 20-Apr-15)
Description
Annotated in NCBI,
envelope protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTACCCTTTGTCCAAGAACAAATTGGGTCATTCATAGTAAACTTTTTCATCTTTACCGTAGTATGTGCTATTACACTCTTGGTGTGTATGGCTTTCCTTACGGCTACTAGATTATGTGTGCAATGCATAACAGGTGTCAATACCCTGTTAGTCCAGCCCGCAGTTTATATGTATAATACTGGACGTTCAGTCTATGTAAAATTCCAGGAGAGTAAACCCCCTCTACCTCCCGAAGAGTGGGTTTAA
Protein
MLPFVQEQIGSFIVNFFIFTVVCAITLLVCMAFLTATRLCVQCITGVNTLLVQPAVYMYNTGRSVYVKFQESKPPLPPEEWV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
PDB
5X29
E-value=4e-05 Score=38.1 Identity=38.98%
Cov(Q)=71.95% Cov(P)=72.84%
Ontologies
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
28.28537
Exp number, first 60 AAs:
27.99499
Total prob of N-in:
0.56262
POSSIBLE N-term signal
sequence