Strain
Porcine_MF769427
(Region: China; Strain: Swine acute diarrhea syndrome coronavirus isolate 75, complete genome.; Date: 2017)
Gene
small membrane protein
Description
Annotated in NCBI,
small membrane protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTTCTGAAGATTGTTGAGGATGATGGTTTGTTCATCAACACAGTCTTGTGGCTTTTAGTGTTGATACTTGTTCTCTTGGTGGCTATCACTGTTATTAAGCTCATACAGCTATGTTTTTCTTGTCATAGGCTTATGAGTAATACCATATACATACCAGTGTATAATGCTTACCTTGTTTACAAGTCTTATATGGAAGTTGAACCATGCCCCATAATTAATGTCTAA
Protein
MFLKIVEDDGLFINTVLWLLVLILVLLVAITVIKLIQLCFSCHRLMSNTIYIPVYNAYLVYKSYMEVEPCPIINV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
75
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
25.48978
Exp number, first 60 AAs:
25.1707
Total prob of N-in:
0.10831
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 75
