Strain

Bat_MG021451 (Region: China; Strain: Middle East respiratory syndrome-related coronavirus isolate NL13845, complete genome.; Date: 17-Jul-13)

Gene

ORF4a

Description

Annotated in NCBI, ORF4a

Location

MG021451(+):25850-26134

GenBank Accession

AVV62528.1

Full name

Non-structural protein 3b

Alternative Name

Accessory protein 3b

Sequence

CDS

ATGGATTACGTGTCCCTGCTTAACCAGGTTTGGCAGCATCACATTAATCTAGCCGTTAATACTGGTGTCTTTGTTGCACCACCTATTGCTGACTTTACTCCTGTCTCTGGTACCACTCTACATCCCGTTCAGTGGCAGTGCAAACTTGATTTTCTTGATTGTACTGGACAGGCAGTTAACACCAGCAAAGCATTAGCAAAACAAGATGCAGCAAGACAAATCGCTTGGCAACTTCACCGCCAGGGCAAATTGTCTGGCTACACCATCCGGTGGCGTTTCAACTAA

Protein

MDYVSLLNQVWQHHINLAVNTGVFVAPPIADFTPVSGTTLHPVQWQCKLDFLDCTGQAVNTSKALAKQDAARQIAWQLHRQGKLSGYTIRWRFN

Summary

Function

Induces host cell G0/G1 arrest and apoptosis.

Subunit

Interacts with host RUNX1 isoform b.

Keywords

Apoptosis Host mitochondrion Host nucleus Host-virus interaction Modulation of host cell apoptosis by virus Modulation of host cell cycle by virus Reference proteome RNA-binding

Feature

chain Non-structural protein 3b

Uniprot

P0C530

Pubmed

16840328

EMBL

DQ648794

Proteomes

UP000007449

Pfam

PF00035 dsrm

Interpro

IPR014720 dsRBD_dom

ProteinModelPortal

P0C530

Ontologies

GO:0044196  C:host cell nucleolus
GO:0039646  P:modulation by virus of host G0/G1 transition checkpoint
GO:0033650  C:host cell mitochondrion
GO:0003723  F:RNA binding
GO:0039526  P:modulation by virus of host apoptotic process

Subcellular Location

From MSLVP

Single-Pass Membrane

From Uniprot

Host nucleus
Host nucleolus
Host mitochondrion

Topology

Length:

Number of predicted TMHs:

Exp number of AAs in TMHs:

0.86228

Exp number, first 60 AAs:

0.86228

Total prob of N-in:

0.26042

outside

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