Strain
Human_NL63_MG428703
(Region: Kenya; Strain: Human coronavirus NL63 isolate Kilifi_HH_0511_01-Jun-2010, complete genome.; Date: 1-Jun-10)
Gene
membrane protein
Description
Annotated in NCBI,
membrane protein
Location
GenBank Accession
Full name
Membrane protein
Alternative Name
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Sequence
CDS
ATGTCTAATAGTAGTGTGCCTCTTTCAGAGGTTTATGTCCATTTACGTAACTGGAACTTTAGTTGGAATTTAATTCTAACAGTTTTTATAGTTGTGTTGCAGTATGGGCATTATATGTATAGCAGATTTCTTTATGGTTTAAAGATGTCTGTTTTATGGTGTTTATGGCCACTTGTTCTAGCTTTGTCTATTTTTGACTGTTTTGTCAATTTTAATGTGGACTGGATCTTTTTTGGTTTTAGTATTCTTATGTCTATTATTACACTTTGTTTATGGGTTATGTATTTTGTTAATAGTTTCAGACTTTGGCGCCGTGTCAAAACTTTTTGGGCTTTTAATCCTGAAACTAATGCAATCATCTCTATCCAGGTTTATGGACATAATTACTACTTACCGGTGATGGCTGCACCTACAGGTGTTACATTAACACTTCTTAGTGGTGTACTTCTTGTTGATGGCCACAAGATTGCTACTCGTGTTCAAGTGGGTCAGTTGCCTAAATATGTAATAGTTGCTACACCTAGTACCACAATTGTTTGTGACCGTGTTGGTCGCTCTGTTAATGAAACAAGCCAGACTGGTTGGGCATTCTACGTCCGTGCTAAACATGGTGATTTTTCTGGTGTTGCCTCTCAGGAGGGTGTTTTGTCAGAAAGAGAGAAGTTGCTTCATTTAATCTAA
Protein
MSNSSVPLSEVYVHLRNWNFSWNLILTVFIVVLQYGHYMYSRFLYGLKMSVLWCLWPLVLALSIFDCFVNFNVDWIFFGFSILMSIITLCLWVMYFVNSFRLWRRVKTFWAFNPETNAIISIQVYGHNYYLPVMAAPTGVTLTLLSGVLLVDGHKIATRVQVGQLPKYVIVATPSTTIVCDRVGRSVNETSQTGWAFYVRAKHGDFSGVASQEGVLSEREKLLHLI
Summary
Function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Similarity
Belongs to the alphacoronaviruses M protein family.
Uniprot
EMBL
Pfam
PF01635
Corona_M
ProteinModelPortal
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
Virion membrane
Virion membrane
Topology
Length:
226
Number of predicted TMHs:
4
Exp number of AAs in TMHs:
87.98446
Exp number, first 60 AAs:
35.4345
Total prob of N-in:
0.17008
POSSIBLE N-term signal
sequence
outside
1 - 19
TMhelix
20 - 38
inside
39 - 42
TMhelix
43 - 65
outside
66 - 74
TMhelix
75 - 97
inside
98 - 128
TMhelix
129 - 151
outside
152 - 226
