Strain

Fish_MG596803 (Region: Italy; Strain: Middle East respiratory syndrome-related coronavirus isolate Bat-CoV/P.khulii/Italy/206645-63/2011, complete genome.; Date: 2011)

Gene

ORF4a protein

Description

Annotated in NCBI, ORF4a protein

Location

MG596803(+):25749-26036

GenBank Accession

AUM60026.1

Full name

Non-structural protein 3b

Alternative Name

Accessory protein 3b

Sequence

CDS

ATGGATTACGTATCTTTGCTTAACGAAGTTTGGCAAAAGTACACTAATTCTGCTTCTACATCTCTGGATTGGTTTCCCAGACCTTATATTGCTTATAAGCCTGTTCCTGGCACTTCCACTCATCCCGTTCAGTGGGAGTGTACATTTACCTTTGCAGGTTTTGTAGGGCAAGCTGTTAACAGCAGTAAAGCATTAGCTAAGCAAGATGCAGCCAGACAAGTTGCCTGGGAATTGCATCGGGAAGGGAAGCTTAACGGCTTCAAGCTTCGATGGTGTCACCCGTTTTAG

Protein

MDYVSLLNEVWQKYTNSASTSLDWFPRPYIAYKPVPGTSTHPVQWECTFTFAGFVGQAVNSSKALAKQDAARQVAWELHREGKLNGFKLRWCHPF

Summary

Function

Induces host cell G0/G1 arrest and apoptosis.

Subunit

Interacts with host RUNX1 isoform b.

Keywords

Apoptosis Host mitochondrion Host nucleus Host-virus interaction Modulation of host cell apoptosis by virus Modulation of host cell cycle by virus Reference proteome RNA-binding

Feature

chain Non-structural protein 3b

Uniprot

P0C530

Pubmed

16840328

EMBL

DQ648794

Proteomes

UP000007449

Pfam

PF00035 dsrm

Interpro

IPR014720 dsRBD_dom

ProteinModelPortal

P0C530

Ontologies

GO:0044196  C:host cell nucleolus
GO:0039646  P:modulation by virus of host G0/G1 transition checkpoint
GO:0033650  C:host cell mitochondrion
GO:0003723  F:RNA binding
GO:0039526  P:modulation by virus of host apoptotic process

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host nucleus
Host nucleolus
Host mitochondrion

Topology

Length:

Number of predicted TMHs:

Exp number of AAs in TMHs:

0.08357

Exp number, first 60 AAs:

0.07627

Total prob of N-in:

0.13391

outside

1 - 95